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3MVI

Crystal structure of holo mADA at 1.6 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0000255biological_processallantoin metabolic process
A0001666biological_processresponse to hypoxia
A0001701biological_processin utero embryonic development
A0001821biological_processhistamine secretion
A0001829biological_processtrophectodermal cell differentiation
A0001883molecular_functionpurine nucleoside binding
A0001889biological_processliver development
A0001890biological_processplacenta development
A0002314biological_processgerminal center B cell differentiation
A0002467biological_processgerminal center formation
A0002636biological_processpositive regulation of germinal center formation
A0002686biological_processnegative regulation of leukocyte migration
A0002901biological_processmature B cell apoptotic process
A0002906biological_processnegative regulation of mature B cell apoptotic process
A0004000molecular_functionadenosine deaminase activity
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006154biological_processadenosine catabolic process
A0006157biological_processdeoxyadenosine catabolic process
A0006196biological_processAMP catabolic process
A0006915biological_processapoptotic process
A0006939biological_processsmooth muscle contraction
A0007155biological_processcell adhesion
A0008270molecular_functionzinc ion binding
A0009117biological_processnucleotide metabolic process
A0009168biological_processpurine ribonucleoside monophosphate biosynthetic process
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010035biological_processresponse to inorganic substance
A0010460biological_processpositive regulation of heart rate
A0014074biological_processresponse to purine-containing compound
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019239molecular_functiondeaminase activity
A0019722biological_processcalcium-mediated signaling
A0030217biological_processT cell differentiation
A0030324biological_processlung development
A0030890biological_processpositive regulation of B cell proliferation
A0031410cellular_componentcytoplasmic vesicle
A0032261biological_processpurine nucleotide salvage
A0032263biological_processGMP salvage
A0032264biological_processIMP salvage
A0032839cellular_componentdendrite cytoplasm
A0033077biological_processT cell differentiation in thymus
A0033081biological_processregulation of T cell differentiation in thymus
A0033089biological_processpositive regulation of T cell differentiation in thymus
A0033197biological_processresponse to vitamin E
A0033632biological_processregulation of cell-cell adhesion mediated by integrin
A0042100biological_processB cell proliferation
A0042110biological_processT cell activation
A0042323biological_processnegative regulation of circadian sleep/wake cycle, non-REM sleep
A0043025cellular_componentneuronal cell body
A0043066biological_processnegative regulation of apoptotic process
A0043084biological_processpenile erection
A0043103biological_processhypoxanthine salvage
A0043605biological_processamide catabolic process
A0044209biological_processAMP salvage
A0045580biological_processregulation of T cell differentiation
A0045582biological_processpositive regulation of T cell differentiation
A0045987biological_processpositive regulation of smooth muscle contraction
A0046059biological_processdAMP catabolic process
A0046061biological_processdATP catabolic process
A0046085biological_processadenosine metabolic process
A0046101biological_processhypoxanthine biosynthetic process
A0046103biological_processinosine biosynthetic process
A0046111biological_processxanthine biosynthetic process
A0046632biological_processalpha-beta T cell differentiation
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0046872molecular_functionmetal ion binding
A0046936molecular_function2'-deoxyadenosine deaminase activity
A0048286biological_processlung alveolus development
A0048541biological_processPeyer's patch development
A0048566biological_processembryonic digestive tract development
A0050728biological_processnegative regulation of inflammatory response
A0050850biological_processpositive regulation of calcium-mediated signaling
A0050852biological_processT cell receptor signaling pathway
A0050862biological_processpositive regulation of T cell receptor signaling pathway
A0050870biological_processpositive regulation of T cell activation
A0050900biological_processleukocyte migration
A0060169biological_processnegative regulation of adenosine receptor signaling pathway
A0060205cellular_componentcytoplasmic vesicle lumen
A0060407biological_processnegative regulation of penile erection
A0070161cellular_componentanchoring junction
A0070242biological_processthymocyte apoptotic process
A0070244biological_processnegative regulation of thymocyte apoptotic process
A0070254biological_processmucus secretion
A0070256biological_processnegative regulation of mucus secretion
A0140928biological_processinhibition of non-skeletal tissue mineralization
B0000255biological_processallantoin metabolic process
B0001666biological_processresponse to hypoxia
B0001701biological_processin utero embryonic development
B0001821biological_processhistamine secretion
B0001829biological_processtrophectodermal cell differentiation
B0001883molecular_functionpurine nucleoside binding
B0001889biological_processliver development
B0001890biological_processplacenta development
B0002314biological_processgerminal center B cell differentiation
B0002467biological_processgerminal center formation
B0002636biological_processpositive regulation of germinal center formation
B0002686biological_processnegative regulation of leukocyte migration
B0002901biological_processmature B cell apoptotic process
B0002906biological_processnegative regulation of mature B cell apoptotic process
B0004000molecular_functionadenosine deaminase activity
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006154biological_processadenosine catabolic process
B0006157biological_processdeoxyadenosine catabolic process
B0006196biological_processAMP catabolic process
B0006915biological_processapoptotic process
B0006939biological_processsmooth muscle contraction
B0007155biological_processcell adhesion
B0008270molecular_functionzinc ion binding
B0009117biological_processnucleotide metabolic process
B0009168biological_processpurine ribonucleoside monophosphate biosynthetic process
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010035biological_processresponse to inorganic substance
B0010460biological_processpositive regulation of heart rate
B0014074biological_processresponse to purine-containing compound
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019239molecular_functiondeaminase activity
B0019722biological_processcalcium-mediated signaling
B0030217biological_processT cell differentiation
B0030324biological_processlung development
B0030890biological_processpositive regulation of B cell proliferation
B0031410cellular_componentcytoplasmic vesicle
B0032261biological_processpurine nucleotide salvage
B0032263biological_processGMP salvage
B0032264biological_processIMP salvage
B0032839cellular_componentdendrite cytoplasm
B0033077biological_processT cell differentiation in thymus
B0033081biological_processregulation of T cell differentiation in thymus
B0033089biological_processpositive regulation of T cell differentiation in thymus
B0033197biological_processresponse to vitamin E
B0033632biological_processregulation of cell-cell adhesion mediated by integrin
B0042100biological_processB cell proliferation
B0042110biological_processT cell activation
B0042323biological_processnegative regulation of circadian sleep/wake cycle, non-REM sleep
B0043025cellular_componentneuronal cell body
B0043066biological_processnegative regulation of apoptotic process
B0043084biological_processpenile erection
B0043103biological_processhypoxanthine salvage
B0043605biological_processamide catabolic process
B0044209biological_processAMP salvage
B0045580biological_processregulation of T cell differentiation
B0045582biological_processpositive regulation of T cell differentiation
B0045987biological_processpositive regulation of smooth muscle contraction
B0046059biological_processdAMP catabolic process
B0046061biological_processdATP catabolic process
B0046085biological_processadenosine metabolic process
B0046101biological_processhypoxanthine biosynthetic process
B0046103biological_processinosine biosynthetic process
B0046111biological_processxanthine biosynthetic process
B0046632biological_processalpha-beta T cell differentiation
B0046638biological_processpositive regulation of alpha-beta T cell differentiation
B0046872molecular_functionmetal ion binding
B0046936molecular_function2'-deoxyadenosine deaminase activity
B0048286biological_processlung alveolus development
B0048541biological_processPeyer's patch development
B0048566biological_processembryonic digestive tract development
B0050728biological_processnegative regulation of inflammatory response
B0050850biological_processpositive regulation of calcium-mediated signaling
B0050852biological_processT cell receptor signaling pathway
B0050862biological_processpositive regulation of T cell receptor signaling pathway
B0050870biological_processpositive regulation of T cell activation
B0050900biological_processleukocyte migration
B0060169biological_processnegative regulation of adenosine receptor signaling pathway
B0060205cellular_componentcytoplasmic vesicle lumen
B0060407biological_processnegative regulation of penile erection
B0070161cellular_componentanchoring junction
B0070242biological_processthymocyte apoptotic process
B0070244biological_processnegative regulation of thymocyte apoptotic process
B0070254biological_processmucus secretion
B0070256biological_processnegative regulation of mucus secretion
B0140928biological_processinhibition of non-skeletal tissue mineralization
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 901
ChainResidue
AHIS15
AHIS17
AHIS214
AASP295
AHOH616

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 902
ChainResidue
AHOH570
AHOH620
AHOH647
AHIS17
AASP19
ALEU106
AHOH539

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN B 901
ChainResidue
BHIS15
BHIS17
BHIS214
BASP295
BHOH619

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 902
ChainResidue
BHIS17
BASP19
BTYR102
BSER103
BLEU106
BHOH361
BHOH554
BHOH639

Functional Information from PROSITE/UniProt
site_idPS00485
Number of Residues7
DetailsA_DEAMINASE Adenosine and AMP deaminase signature. SLNTDDP
ChainResidueDetails
ASER291-PRO297

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000305|PubMed:8634299, ECO:0000305|PubMed:9622483
ChainResidueDetails
AGLU217
BGLU217

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:1925539, ECO:0000269|PubMed:8672487, ECO:0000269|PubMed:8942668, ECO:0000269|PubMed:9622483, ECO:0007744|PDB:1A4L, ECO:0007744|PDB:1A4M, ECO:0007744|PDB:1FKW, ECO:0007744|PDB:1FKX, ECO:0007744|PDB:1UIO, ECO:0007744|PDB:1UIP, ECO:0007744|PDB:2ADA
ChainResidueDetails
AHIS15
AHIS17
AHIS214
AASP295
BHIS15
BHIS17
BHIS214
BASP295

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:1925539, ECO:0000269|PubMed:8672487, ECO:0000269|PubMed:8942668, ECO:0000269|PubMed:9622483, ECO:0007744|PDB:1A4L, ECO:0007744|PDB:1A4M, ECO:0007744|PDB:1FKW, ECO:0007744|PDB:1FKX
ChainResidueDetails
AASP19
BASP19

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:1925539, ECO:0000269|PubMed:8672487, ECO:0000269|PubMed:8942668, ECO:0000269|PubMed:9622483, ECO:0007744|PDB:1A4M, ECO:0007744|PDB:1FKX, ECO:0007744|PDB:1UIO, ECO:0007744|PDB:1UIP, ECO:0007744|PDB:2ADA
ChainResidueDetails
AGLY184
BGLY184

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:8672487, ECO:0000269|PubMed:8942668, ECO:0007744|PDB:1FKW, ECO:0007744|PDB:1UIP
ChainResidueDetails
AASP296
BASP296

site_idSWS_FT_FI6
Number of Residues4
DetailsSITE: Important for interaction with adenosine receptors and increasing their affinity for agonists => ECO:0000250|UniProtKB:P00813
ChainResidueDetails
BLEU58
BLEU62
ALEU58
ALEU62

site_idSWS_FT_FI7
Number of Residues2
DetailsSITE: Important for catalytic activity => ECO:0000269|PubMed:8942668, ECO:0000269|PubMed:9622483
ChainResidueDetails
AHIS238
BHIS238

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P00813
ChainResidueDetails
ALYS54
ALYS232
BLYS54
BLYS232

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 376
ChainResidueDetails
AHIS15metal ligand
AHIS17metal ligand
AHIS214metal ligand
AGLU217proton shuttle (general acid/base)
AHIS238proton shuttle (general acid/base)
AASP295metal ligand, steric role

site_idMCSA2
Number of Residues6
DetailsM-CSA 376
ChainResidueDetails
BHIS15metal ligand
BHIS17metal ligand
BHIS214metal ligand
BGLU217proton shuttle (general acid/base)
BHIS238proton shuttle (general acid/base)
BASP295metal ligand, steric role

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PDB entries from 2024-06-12

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