3MV4
Axial Ligand Swapping In Double Mutant Maintains Intradiol-cleavage Chemistry in Protocatechuate 3,4-Dioxygenase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0008199 | molecular_function | ferric iron binding |
A | 0009056 | biological_process | catabolic process |
A | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
A | 0018578 | molecular_function | protocatechuate 3,4-dioxygenase activity |
A | 0042952 | biological_process | beta-ketoadipate pathway |
A | 0051213 | molecular_function | dioxygenase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0008199 | molecular_function | ferric iron binding |
B | 0009056 | biological_process | catabolic process |
B | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
B | 0018578 | molecular_function | protocatechuate 3,4-dioxygenase activity |
B | 0042952 | biological_process | beta-ketoadipate pathway |
B | 0051213 | molecular_function | dioxygenase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0005506 | molecular_function | iron ion binding |
C | 0008199 | molecular_function | ferric iron binding |
C | 0009056 | biological_process | catabolic process |
C | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
C | 0018578 | molecular_function | protocatechuate 3,4-dioxygenase activity |
C | 0042952 | biological_process | beta-ketoadipate pathway |
C | 0051213 | molecular_function | dioxygenase activity |
M | 0003824 | molecular_function | catalytic activity |
M | 0005506 | molecular_function | iron ion binding |
M | 0008199 | molecular_function | ferric iron binding |
M | 0009056 | biological_process | catabolic process |
M | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
M | 0018578 | molecular_function | protocatechuate 3,4-dioxygenase activity |
M | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
M | 0042952 | biological_process | beta-ketoadipate pathway |
M | 0046872 | molecular_function | metal ion binding |
M | 0051213 | molecular_function | dioxygenase activity |
N | 0003824 | molecular_function | catalytic activity |
N | 0005506 | molecular_function | iron ion binding |
N | 0008199 | molecular_function | ferric iron binding |
N | 0009056 | biological_process | catabolic process |
N | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
N | 0018578 | molecular_function | protocatechuate 3,4-dioxygenase activity |
N | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
N | 0042952 | biological_process | beta-ketoadipate pathway |
N | 0046872 | molecular_function | metal ion binding |
N | 0051213 | molecular_function | dioxygenase activity |
O | 0003824 | molecular_function | catalytic activity |
O | 0005506 | molecular_function | iron ion binding |
O | 0008199 | molecular_function | ferric iron binding |
O | 0009056 | biological_process | catabolic process |
O | 0016702 | molecular_function | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
O | 0018578 | molecular_function | protocatechuate 3,4-dioxygenase activity |
O | 0019619 | biological_process | 3,4-dihydroxybenzoate catabolic process |
O | 0042952 | biological_process | beta-ketoadipate pathway |
O | 0046872 | molecular_function | metal ion binding |
O | 0051213 | molecular_function | dioxygenase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 201 |
Chain | Residue |
A | ASN37 |
A | THR105 |
A | HIS107 |
A | HOH705 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 0 |
Chain | Residue |
A | ARG188 |
A | HOH1110 |
A | HOH1316 |
A | THR169 |
A | ILE171 |
A | ARG184 |
A | PHE185 |
A | ASP186 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE BME A 202 |
Chain | Residue |
A | TYR56 |
A | ASP57 |
A | GLY60 |
A | ARG188 |
A | GLN190 |
A | GLY191 |
A | GLU192 |
A | HOH1108 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 201 |
Chain | Residue |
B | ASN37 |
B | ARG38 |
B | THR105 |
B | HIS107 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL B 202 |
Chain | Residue |
B | ILE171 |
B | ARG184 |
B | PHE185 |
B | ASP186 |
B | HOH1367 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 C 201 |
Chain | Residue |
C | ASN37 |
C | THR105 |
C | HIS107 |
C | HOH833 |
C | HOH1031 |
site_id | AC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GOL C 202 |
Chain | Residue |
C | GLU168 |
C | THR169 |
C | ILE171 |
C | ALA172 |
C | ARG184 |
C | PHE185 |
C | ASP186 |
C | ARG188 |
C | HOH1197 |
C | HOH1490 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 M 6 |
Chain | Residue |
M | ARG414 |
M | ARG450 |
M | HOH1283 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL M 2 |
Chain | Residue |
M | ARG409 |
M | LEU419 |
M | PRO421 |
M | HOH567 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE M 600 |
Chain | Residue |
M | TYR408 |
M | HIS447 |
M | HIS460 |
M | TYR462 |
M | CO3543 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL M 1 |
Chain | Residue |
M | GLN503 |
M | ILE505 |
M | LYS507 |
M | ARG522 |
M | PHE523 |
M | ASP524 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE BME M 539 |
Chain | Residue |
A | ARG31 |
M | ASP360 |
M | ASN366 |
M | VAL426 |
M | GLY427 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE BME M 540 |
Chain | Residue |
M | PHE356 |
M | CYS429 |
M | LEU430 |
M | HOH587 |
site_id | BC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE BME M 541 |
Chain | Residue |
A | PRO15 |
A | ARG133 |
M | HOH220 |
M | TYR324 |
M | THR326 |
M | TRP449 |
M | ILE491 |
M | CO3543 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE BME M 542 |
Chain | Residue |
M | GLY482 |
M | GLN502 |
M | ILE505 |
M | LYS507 |
M | HOH797 |
site_id | BC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE CO3 M 543 |
Chain | Residue |
A | TYR16 |
M | HOH220 |
M | TYR408 |
M | HIS447 |
M | ARG457 |
M | HIS460 |
M | TYR462 |
M | BME541 |
M | FE600 |
M | HOH1450 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 N 4 |
Chain | Residue |
N | ARG409 |
N | PRO421 |
N | HOH586 |
site_id | BC9 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 N 5 |
Chain | Residue |
M | ARG383 |
site_id | CC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE BME N 1 |
Chain | Residue |
N | HOH296 |
N | PHE356 |
N | CYS429 |
N | LEU430 |
N | HOH611 |
N | HOH940 |
A | GLU176 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE N 600 |
Chain | Residue |
N | TYR408 |
N | HIS447 |
N | HIS460 |
N | TYR462 |
N | CO3542 |
site_id | CC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL N 539 |
Chain | Residue |
N | GLN503 |
N | ILE505 |
N | LYS507 |
N | ARG522 |
N | PHE523 |
N | ASP524 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CO3 N 540 |
Chain | Residue |
N | HOH257 |
N | ARG450 |
O | HOH225 |
O | SER338 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CO3 N 541 |
Chain | Residue |
M | ILE328 |
N | ARG333 |
N | HOH721 |
N | HOH928 |
site_id | CC6 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE CO3 N 542 |
Chain | Residue |
B | TYR16 |
N | HOH82 |
N | TYR408 |
N | HIS447 |
N | ARG457 |
N | HIS460 |
N | TYR462 |
N | FE600 |
N | HOH1451 |
N | HOH1555 |
site_id | CC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE BME N 543 |
Chain | Residue |
B | PRO15 |
B | ARG133 |
N | HOH82 |
N | TYR324 |
N | THR326 |
N | TRP449 |
N | HOH1555 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE BME N 544 |
Chain | Residue |
N | HIS534 |
N | PHE535 |
N | GLU536 |
N | HOH1084 |
site_id | CC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 O 7 |
Chain | Residue |
O | ARG409 |
O | LEU419 |
O | PRO421 |
O | HOH543 |
site_id | DC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE O 600 |
Chain | Residue |
O | CO31 |
O | TYR408 |
O | HIS447 |
O | HIS460 |
O | TYR462 |
site_id | DC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE CO3 O 1 |
Chain | Residue |
C | TYR16 |
O | HOH172 |
O | TYR408 |
O | HIS447 |
O | ARG457 |
O | HIS460 |
O | TYR462 |
O | FE600 |
O | HOH1086 |
O | HOH1563 |
site_id | DC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE BME O 539 |
Chain | Residue |
C | GLY14 |
C | PRO15 |
C | ARG133 |
O | HOH172 |
O | TYR324 |
O | THR326 |
O | TRP449 |
O | HOH1563 |
site_id | DC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE BME O 540 |
Chain | Residue |
N | SER438 |
O | HIS534 |
O | PHE535 |
site_id | DC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE BME O 541 |
Chain | Residue |
C | ARG31 |
C | ASP32 |
C | HOH1579 |
O | GLY357 |
O | ASP360 |
O | HOH608 |
Functional Information from PROSITE/UniProt
site_id | PS00083 |
Number of Residues | 29 |
Details | INTRADIOL_DIOXYGENAS Intradiol ring-cleavage dioxygenases signature. VaGrVvdqyGkpVpntlVEMwqanagGrY |
Chain | Residue | Details |
M | VAL380-TYR408 | |
A | LEU51-TYR79 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:7990141 |
Chain | Residue | Details |
M | TYR408 | |
O | HIS447 | |
O | HIS460 | |
O | TYR462 | |
M | HIS447 | |
M | HIS460 | |
M | TYR462 | |
N | TYR408 | |
N | HIS447 | |
N | HIS460 | |
N | TYR462 | |
O | TYR408 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 936 |
Chain | Residue | Details |
M | TYR408 | metal ligand |
M | HIS447 | metal ligand, proton shuttle (general acid/base) |
M | ARG457 | electrostatic stabiliser |
M | HIS460 | metal ligand |
M | TYR462 | metal ligand |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 936 |
Chain | Residue | Details |
N | TYR408 | metal ligand |
N | HIS447 | metal ligand, proton shuttle (general acid/base) |
N | ARG457 | electrostatic stabiliser |
N | HIS460 | metal ligand |
N | TYR462 | metal ligand |
site_id | MCSA3 |
Number of Residues | 5 |
Details | M-CSA 936 |
Chain | Residue | Details |
O | TYR408 | metal ligand |
O | HIS447 | metal ligand, proton shuttle (general acid/base) |
O | ARG457 | electrostatic stabiliser |
O | HIS460 | metal ligand |
O | TYR462 | metal ligand |