3MV1
E.Coli (lacZ) beta-galactosidase (R599A) in complex with Guanidinium
Functional Information from GO Data
Chain | GOid | namespace | contents |
1 | 0000287 | molecular_function | magnesium ion binding |
1 | 0003824 | molecular_function | catalytic activity |
1 | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
1 | 0004565 | molecular_function | beta-galactosidase activity |
1 | 0005975 | biological_process | carbohydrate metabolic process |
1 | 0005990 | biological_process | lactose catabolic process |
1 | 0009341 | cellular_component | beta-galactosidase complex |
1 | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
1 | 0030246 | molecular_function | carbohydrate binding |
1 | 0031420 | molecular_function | alkali metal ion binding |
1 | 0042802 | molecular_function | identical protein binding |
1 | 0046872 | molecular_function | metal ion binding |
2 | 0000287 | molecular_function | magnesium ion binding |
2 | 0003824 | molecular_function | catalytic activity |
2 | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
2 | 0004565 | molecular_function | beta-galactosidase activity |
2 | 0005975 | biological_process | carbohydrate metabolic process |
2 | 0005990 | biological_process | lactose catabolic process |
2 | 0009341 | cellular_component | beta-galactosidase complex |
2 | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
2 | 0030246 | molecular_function | carbohydrate binding |
2 | 0031420 | molecular_function | alkali metal ion binding |
2 | 0042802 | molecular_function | identical protein binding |
2 | 0046872 | molecular_function | metal ion binding |
3 | 0000287 | molecular_function | magnesium ion binding |
3 | 0003824 | molecular_function | catalytic activity |
3 | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
3 | 0004565 | molecular_function | beta-galactosidase activity |
3 | 0005975 | biological_process | carbohydrate metabolic process |
3 | 0005990 | biological_process | lactose catabolic process |
3 | 0009341 | cellular_component | beta-galactosidase complex |
3 | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
3 | 0030246 | molecular_function | carbohydrate binding |
3 | 0031420 | molecular_function | alkali metal ion binding |
3 | 0042802 | molecular_function | identical protein binding |
3 | 0046872 | molecular_function | metal ion binding |
4 | 0000287 | molecular_function | magnesium ion binding |
4 | 0003824 | molecular_function | catalytic activity |
4 | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
4 | 0004565 | molecular_function | beta-galactosidase activity |
4 | 0005975 | biological_process | carbohydrate metabolic process |
4 | 0005990 | biological_process | lactose catabolic process |
4 | 0009341 | cellular_component | beta-galactosidase complex |
4 | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
4 | 0030246 | molecular_function | carbohydrate binding |
4 | 0031420 | molecular_function | alkali metal ion binding |
4 | 0042802 | molecular_function | identical protein binding |
4 | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 1 3001 |
Chain | Residue |
1 | GLU416 |
1 | HIS418 |
1 | GLU461 |
1 | HOH4012 |
1 | HOH4076 |
1 | HOH4152 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG 1 3002 |
Chain | Residue |
1 | GLN163 |
1 | ASP193 |
1 | ASP15 |
1 | ASN18 |
1 | VAL21 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG 1 3004 |
Chain | Residue |
1 | GLN718 |
1 | THR911 |
1 | HOH4256 |
1 | HOH4362 |
1 | HOH4559 |
1 | HOH4600 |
1 | HOH4810 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA 1 3101 |
Chain | Residue |
1 | ASP201 |
1 | PHE601 |
1 | ASN604 |
1 | HOH4266 |
1 | HOH4928 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 1 3102 |
Chain | Residue |
1 | PHE556 |
1 | TYR559 |
1 | PRO560 |
1 | LEU562 |
1 | HOH4384 |
1 | HOH4561 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA 1 3103 |
Chain | Residue |
1 | PHE931 |
1 | PRO932 |
1 | LEU967 |
1 | MET968 |
1 | THR970 |
1 | HOH4200 |
1 | HOH4492 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 1 3104 |
Chain | Residue |
1 | SER647 |
1 | ASP648 |
1 | ASN649 |
1 | GLU650 |
1 | LEU670 |
1 | HOH4634 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GAI 1 2001 |
Chain | Residue |
1 | ASP598 |
1 | PHE601 |
1 | GLU797 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS 1 7000 |
Chain | Residue |
1 | THR229 |
1 | VAL330 |
1 | GLY331 |
1 | ASN449 |
1 | PRO451 |
1 | ARG482 |
1 | HOH4009 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7001 |
Chain | Residue |
1 | ARG557 |
1 | HIS622 |
1 | GLN628 |
1 | HOH4198 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 1 7002 |
Chain | Residue |
1 | LYS380 |
1 | ASN383 |
1 | PHE626 |
1 | TYR642 |
1 | TRP708 |
1 | HOH4207 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 1 7003 |
Chain | Residue |
1 | PRO32 |
1 | PHE33 |
1 | TRP36 |
1 | ALA327 |
1 | HOH4395 |
1 | HOH4893 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 7004 |
Chain | Residue |
1 | THR271 |
1 | LEU291 |
1 | ARG292 |
site_id | BC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 1 7005 |
Chain | Residue |
1 | GLU314 |
1 | GLY320 |
site_id | BC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 1 7006 |
Chain | Residue |
1 | ARG505 |
1 | GLU508 |
1 | PRO1001 |
1 | SER1002 |
1 | VAL1003 |
1 | HOH4035 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7007 |
Chain | Residue |
1 | VAL335 |
1 | ARG336 |
1 | PRO480 |
1 | HOH4205 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7008 |
Chain | Residue |
1 | PRO584 |
1 | SER586 |
1 | ARG973 |
1 | HOH4099 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7009 |
Chain | Residue |
1 | GLY275 |
1 | VAL289 |
1 | THR290 |
1 | ARG292 |
site_id | CC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 7010 |
Chain | Residue |
1 | VAL84 |
1 | VAL85 |
1 | HIS93 |
site_id | CC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 7011 |
Chain | Residue |
1 | TYR105 |
1 | PRO106 |
1 | THR108 |
site_id | CC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 1 7012 |
Chain | Residue |
1 | HIS93 |
1 | GLY94 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7013 |
Chain | Residue |
1 | TRP36 |
1 | ASP45 |
1 | ARG46 |
1 | PRO47 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7014 |
Chain | Residue |
1 | PHE629 |
1 | GLN718 |
1 | TRP720 |
1 | HOH4229 |
site_id | CC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 7015 |
Chain | Residue |
1 | ARG37 |
1 | GLN50 |
1 | HIS216 |
site_id | CC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7016 |
Chain | Residue |
1 | GLN266 |
1 | VAL267 |
1 | ALA268 |
1 | SER269 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7017 |
Chain | Residue |
1 | ARG230 |
1 | PHE231 |
1 | ARG237 |
1 | VAL239 |
site_id | CC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 7018 |
Chain | Residue |
1 | TYR472 |
1 | THR494 |
1 | THR496 |
site_id | DC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7019 |
Chain | Residue |
1 | ARG630 |
1 | SER632 |
1 | THR635 |
1 | GLU637 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7020 |
Chain | Residue |
1 | ILE737 |
1 | GLU750 |
1 | LEU751 |
1 | GLY752 |
site_id | DC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 7021 |
Chain | Residue |
1 | ALA707 |
1 | TRP708 |
1 | SER709 |
1 | GLU710 |
site_id | DC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS 1 7022 |
Chain | Residue |
1 | HIS418 |
site_id | DC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 7023 |
Chain | Residue |
1 | LEU54 |
1 | ASN55 |
1 | LEU125 |
site_id | DC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 1 7024 |
Chain | Residue |
1 | GLU57 |
1 | ARG59 |
1 | LEU125 |
1 | THR126 |
1 | HOH4839 |
site_id | DC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 2 3001 |
Chain | Residue |
2 | GLU416 |
2 | HIS418 |
2 | GLU461 |
2 | HOH4012 |
2 | HOH4076 |
2 | HOH4152 |
site_id | DC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG 2 3002 |
Chain | Residue |
2 | ASP15 |
2 | ASN18 |
2 | VAL21 |
2 | GLN163 |
2 | ASP193 |
site_id | DC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 2 3004 |
Chain | Residue |
2 | GLN718 |
2 | THR911 |
2 | HOH4259 |
2 | HOH4584 |
2 | HOH4640 |
2 | HOH4828 |
site_id | EC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA 2 3101 |
Chain | Residue |
2 | ASP201 |
2 | PHE601 |
2 | ASN604 |
2 | HOH4269 |
2 | HOH4993 |
site_id | EC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 2 3102 |
Chain | Residue |
2 | PHE556 |
2 | TYR559 |
2 | PRO560 |
2 | LEU562 |
2 | HOH4386 |
2 | HOH4587 |
site_id | EC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 2 3103 |
Chain | Residue |
2 | PHE931 |
2 | PRO932 |
2 | LEU967 |
2 | THR970 |
2 | HOH4202 |
2 | HOH4671 |
site_id | EC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA 2 3104 |
Chain | Residue |
2 | SER647 |
2 | GLU650 |
2 | LEU670 |
2 | HOH5067 |
2 | DMS7016 |
site_id | EC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GAI 2 2001 |
Chain | Residue |
2 | ASP598 |
2 | PHE601 |
2 | GLU797 |
site_id | EC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS 2 7000 |
Chain | Residue |
2 | THR229 |
2 | VAL330 |
2 | GLY331 |
2 | ASN449 |
2 | PRO451 |
2 | ARG482 |
2 | HOH4009 |
site_id | EC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 7001 |
Chain | Residue |
2 | ARG557 |
2 | HIS622 |
2 | GLN623 |
2 | GLN628 |
2 | HOH4200 |
site_id | EC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 2 7002 |
Chain | Residue |
2 | LYS380 |
2 | ASN383 |
2 | PHE626 |
2 | TYR642 |
2 | TRP708 |
2 | HOH4209 |
site_id | EC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 7003 |
Chain | Residue |
2 | PRO32 |
2 | PHE33 |
2 | TRP36 |
2 | ALA327 |
2 | HOH4398 |
site_id | FC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 7004 |
Chain | Residue |
2 | THR271 |
2 | LEU291 |
2 | ARG292 |
2 | HOH4642 |
site_id | FC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 7005 |
Chain | Residue |
1 | HOH4548 |
2 | THR257 |
2 | GLU314 |
2 | HIS316 |
2 | GLY320 |
site_id | FC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 2 7006 |
Chain | Residue |
2 | GLU334 |
2 | VAL335 |
2 | PRO480 |
2 | HOH4204 |
2 | HOH4207 |
2 | HOH4488 |
site_id | FC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7007 |
Chain | Residue |
2 | ILE99 |
2 | PRO106 |
2 | HOH4257 |
site_id | FC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7008 |
Chain | Residue |
2 | TRP585 |
2 | SER586 |
2 | ARG973 |
site_id | FC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 7009 |
Chain | Residue |
2 | GLY275 |
2 | VAL289 |
2 | THR290 |
2 | ARG292 |
2 | HOH4762 |
site_id | FC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7010 |
Chain | Residue |
2 | THR83 |
2 | VAL85 |
2 | HIS93 |
site_id | FC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7011 |
Chain | Residue |
2 | LEU250 |
2 | ARG251 |
2 | ASP252 |
site_id | FC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 7012 |
Chain | Residue |
2 | PHE231 |
2 | ASN232 |
2 | ASP233 |
2 | GLU334 |
site_id | GC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 7013 |
Chain | Residue |
2 | ASP428 |
2 | PRO430 |
2 | HOH4456 |
3 | VAL478 |
site_id | GC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 2 7014 |
Chain | Residue |
2 | HIS93 |
2 | GLY94 |
site_id | GC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7015 |
Chain | Residue |
2 | TYR926 |
2 | TYR962 |
2 | ARG973 |
site_id | GC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 7016 |
Chain | Residue |
2 | ASP648 |
2 | ASN649 |
2 | GLU650 |
2 | NA3104 |
site_id | GC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 7017 |
Chain | Residue |
2 | ARG37 |
2 | GLN50 |
2 | SER132 |
2 | TRP133 |
site_id | GC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7018 |
Chain | Residue |
2 | SER923 |
2 | ARG961 |
2 | TYR962 |
site_id | GC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 7019 |
Chain | Residue |
2 | VAL267 |
2 | ASN294 |
2 | VAL295 |
2 | GLU296 |
site_id | GC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7020 |
Chain | Residue |
2 | GLU369 |
2 | LEU401 |
2 | ARG404 |
site_id | GC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 2 7021 |
Chain | Residue |
2 | ARG404 |
2 | TYR405 |
site_id | HC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 2 7022 |
Chain | Residue |
2 | PRO306 |
2 | ASN307 |
site_id | HC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7023 |
Chain | Residue |
2 | THR706 |
2 | SER709 |
2 | GLU710 |
site_id | HC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 2 7024 |
Chain | Residue |
2 | ARG630 |
2 | SER632 |
site_id | HC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 7025 |
Chain | Residue |
2 | TYR105 |
2 | PRO106 |
2 | THR108 |
2 | HOH4449 |
site_id | HC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 2 7026 |
Chain | Residue |
2 | ASP45 |
2 | HOH4594 |
site_id | HC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7027 |
Chain | Residue |
2 | ASN102 |
2 | TRP999 |
2 | HOH4819 |
site_id | HC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7028 |
Chain | Residue |
2 | GLN49 |
3 | SER48 |
3 | LEU51 |
site_id | HC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 7029 |
Chain | Residue |
2 | LEU54 |
2 | ASN55 |
2 | LEU125 |
site_id | HC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 3 3001 |
Chain | Residue |
3 | GLU416 |
3 | HIS418 |
3 | GLU461 |
3 | HOH4013 |
3 | HOH4076 |
3 | HOH4154 |
site_id | IC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG 3 3002 |
Chain | Residue |
3 | ASP15 |
3 | ASN18 |
3 | VAL21 |
3 | GLN163 |
3 | ASP193 |
site_id | IC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 3 3004 |
Chain | Residue |
3 | GLN718 |
3 | HOH4258 |
3 | HOH4375 |
3 | HOH4638 |
3 | HOH4868 |
3 | HOH4921 |
site_id | IC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA 3 3101 |
Chain | Residue |
3 | ASP201 |
3 | PHE601 |
3 | ASN604 |
3 | HOH4268 |
3 | HOH4986 |
site_id | IC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 3 3102 |
Chain | Residue |
3 | PHE556 |
3 | TYR559 |
3 | PRO560 |
3 | LEU562 |
3 | HOH4388 |
3 | HOH4591 |
site_id | IC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 3 3103 |
Chain | Residue |
3 | PHE931 |
3 | PRO932 |
3 | LEU967 |
3 | THR970 |
3 | HOH4202 |
3 | HOH4664 |
site_id | IC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA 3 3104 |
Chain | Residue |
3 | SER647 |
3 | GLU650 |
3 | LEU670 |
3 | DMS7016 |
site_id | IC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GAI 3 2001 |
Chain | Residue |
3 | ASP598 |
3 | VAL795 |
3 | GLU797 |
site_id | IC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS 3 7000 |
Chain | Residue |
3 | THR229 |
3 | VAL330 |
3 | GLY331 |
3 | ARG448 |
3 | ASN449 |
3 | ARG482 |
3 | HOH4010 |
site_id | IC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 7001 |
Chain | Residue |
3 | ARG557 |
3 | HIS622 |
3 | GLN623 |
3 | GLN628 |
3 | HOH4200 |
site_id | JC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 3 7002 |
Chain | Residue |
3 | LYS380 |
3 | ASN383 |
3 | PHE626 |
3 | TYR642 |
3 | TRP708 |
3 | HOH4209 |
site_id | JC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 7003 |
Chain | Residue |
3 | PRO32 |
3 | PHE33 |
3 | TRP36 |
3 | ALA327 |
3 | HOH4401 |
site_id | JC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 7004 |
Chain | Residue |
3 | THR271 |
3 | LEU291 |
3 | ARG292 |
3 | HOH4992 |
site_id | JC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 7005 |
Chain | Residue |
3 | GLU508 |
3 | PRO1001 |
3 | VAL1003 |
3 | HOH4036 |
site_id | JC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 7006 |
Chain | Residue |
3 | PRO480 |
3 | HOH4204 |
3 | HOH4207 |
site_id | JC6 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS 3 7007 |
Chain | Residue |
3 | PRO106 |
site_id | JC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 7008 |
Chain | Residue |
3 | ILE576 |
3 | TRP585 |
3 | SER586 |
3 | ARG973 |
3 | HOH4100 |
site_id | JC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 7009 |
Chain | Residue |
3 | GLY275 |
3 | GLY276 |
3 | VAL289 |
3 | THR290 |
3 | ARG292 |
site_id | JC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 7010 |
Chain | Residue |
3 | VAL84 |
3 | VAL85 |
3 | HIS93 |
site_id | KC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 7011 |
Chain | Residue |
3 | LYS621 |
3 | ILE714 |
3 | HOH4323 |
3 | DMS7025 |
site_id | KC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 7012 |
Chain | Residue |
3 | LEU250 |
3 | ARG251 |
3 | ASP252 |
site_id | KC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 7013 |
Chain | Residue |
2 | HOH4406 |
3 | ASP428 |
3 | PRO430 |
site_id | KC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 3 7014 |
Chain | Residue |
3 | HIS93 |
3 | GLY94 |
site_id | KC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 7015 |
Chain | Residue |
2 | ASN581 |
3 | TYR926 |
3 | TYR962 |
3 | ARG973 |
site_id | KC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 7016 |
Chain | Residue |
3 | ASN649 |
3 | GLU650 |
3 | ASN704 |
3 | NA3104 |
site_id | KC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS 3 7017 |
Chain | Residue |
3 | TRP36 |
3 | ASP45 |
3 | ARG46 |
3 | PRO47 |
3 | SER48 |
3 | HOH4480 |
3 | HOH4705 |
site_id | KC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 7018 |
Chain | Residue |
3 | GLN266 |
3 | VAL267 |
3 | ALA268 |
4 | LEU740 |
4 | THR742 |
site_id | KC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 7019 |
Chain | Residue |
3 | TYR105 |
3 | PRO106 |
3 | ILE107 |
3 | THR108 |
site_id | LC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 7020 |
Chain | Residue |
3 | ARG630 |
3 | SER632 |
3 | THR635 |
3 | GLU637 |
site_id | LC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 7021 |
Chain | Residue |
3 | THR706 |
3 | ALA707 |
3 | TRP708 |
3 | SER709 |
3 | GLU710 |
site_id | LC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 3 7022 |
Chain | Residue |
3 | ARG404 |
3 | TYR405 |
site_id | LC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 7023 |
Chain | Residue |
3 | GLU314 |
3 | HIS316 |
3 | GLY320 |
site_id | LC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 7024 |
Chain | Residue |
3 | ARG37 |
3 | SER132 |
3 | TRP133 |
3 | GLU136 |
3 | HIS216 |
site_id | LC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 7025 |
Chain | Residue |
3 | ILE714 |
3 | TRP717 |
3 | HOH4892 |
3 | DMS7011 |
site_id | LC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 3 7026 |
Chain | Residue |
3 | ASN102 |
3 | HIS418 |
site_id | LC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 1024 |
Chain | Residue |
3 | LEU54 |
3 | ASN55 |
3 | LEU125 |
site_id | LC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 4 3001 |
Chain | Residue |
4 | GLU416 |
4 | HIS418 |
4 | GLU461 |
4 | HOH4012 |
4 | HOH4076 |
4 | HOH4153 |
site_id | MC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG 4 3002 |
Chain | Residue |
4 | ASP15 |
4 | ASN18 |
4 | VAL21 |
4 | GLN163 |
4 | ASP193 |
site_id | MC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG 4 3004 |
Chain | Residue |
4 | GLN718 |
4 | THR911 |
4 | HOH4260 |
4 | HOH4567 |
4 | HOH4611 |
site_id | MC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA 4 3101 |
Chain | Residue |
4 | ASP201 |
4 | PHE601 |
4 | ASN604 |
4 | HOH4270 |
site_id | MC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 4 3102 |
Chain | Residue |
4 | PHE556 |
4 | TYR559 |
4 | PRO560 |
4 | LEU562 |
4 | HOH4389 |
4 | HOH4570 |
site_id | MC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE NA 4 3103 |
Chain | Residue |
4 | PHE931 |
4 | PRO932 |
4 | LEU967 |
4 | MET968 |
4 | THR970 |
4 | HOH4203 |
4 | HOH4506 |
4 | HOH4640 |
site_id | MC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 4 3104 |
Chain | Residue |
4 | SER647 |
4 | ASP648 |
4 | ASN649 |
4 | GLU650 |
4 | LEU670 |
4 | HOH4755 |
site_id | MC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GAI 4 2001 |
Chain | Residue |
4 | ASP598 |
4 | PHE601 |
4 | VAL795 |
4 | GLU797 |
4 | DMS7025 |
site_id | MC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS 4 7000 |
Chain | Residue |
4 | THR229 |
4 | VAL330 |
4 | GLY331 |
4 | ASN449 |
4 | PRO451 |
4 | ARG482 |
4 | HOH4009 |
site_id | MC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 4 7001 |
Chain | Residue |
4 | ARG557 |
4 | HIS622 |
4 | GLN623 |
4 | GLN625 |
4 | GLN628 |
site_id | NC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 4 7002 |
Chain | Residue |
4 | LYS380 |
4 | ASN383 |
4 | PHE626 |
4 | TYR642 |
4 | TRP708 |
4 | HOH4210 |
site_id | NC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DMS 4 7003 |
Chain | Residue |
4 | PRO32 |
4 | PHE33 |
4 | TRP36 |
4 | ALA327 |
4 | HOH4401 |
4 | HOH4461 |
4 | HOH4839 |
4 | DMS7015 |
site_id | NC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 7004 |
Chain | Residue |
4 | THR271 |
4 | LEU291 |
4 | ARG292 |
site_id | NC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 7005 |
Chain | Residue |
4 | GLU314 |
4 | HIS316 |
4 | GLY320 |
site_id | NC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 7006 |
Chain | Residue |
4 | VAL335 |
4 | PRO480 |
4 | HOH4208 |
site_id | NC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 4 7007 |
Chain | Residue |
4 | GLU117 |
4 | HOH4355 |
site_id | NC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 4 7008 |
Chain | Residue |
4 | PRO584 |
4 | TRP585 |
4 | SER586 |
4 | ARG973 |
4 | HOH4100 |
site_id | NC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 7009 |
Chain | Residue |
4 | GLY275 |
4 | THR290 |
4 | ARG292 |
4 | HOH4549 |
site_id | NC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 7010 |
Chain | Residue |
4 | THR83 |
4 | VAL84 |
4 | VAL85 |
4 | HIS93 |
site_id | OC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 7011 |
Chain | Residue |
4 | LEU250 |
4 | ARG251 |
4 | ASP252 |
site_id | OC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 7012 |
Chain | Residue |
4 | TYR105 |
4 | PRO106 |
4 | THR108 |
site_id | OC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 4 7013 |
Chain | Residue |
4 | HIS93 |
4 | GLY94 |
site_id | OC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 7014 |
Chain | Residue |
4 | TYR926 |
4 | TYR962 |
4 | ARG973 |
4 | LEU976 |
site_id | OC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS 4 7015 |
Chain | Residue |
4 | ALA34 |
4 | TRP36 |
4 | ASP45 |
4 | ARG46 |
4 | PRO47 |
4 | HOH4475 |
4 | DMS7003 |
site_id | OC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 7016 |
Chain | Residue |
4 | PHE629 |
4 | GLN718 |
4 | TRP720 |
4 | HOH4234 |
site_id | OC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 7017 |
Chain | Residue |
4 | SER923 |
4 | TYR926 |
4 | TYR962 |
4 | HOH4109 |
site_id | OC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 7018 |
Chain | Residue |
4 | LEU134 |
4 | GLN135 |
4 | SER174 |
site_id | OC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 7019 |
Chain | Residue |
4 | ILE737 |
4 | GLU750 |
4 | LEU751 |
4 | GLY752 |
site_id | PC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 4 7020 |
Chain | Residue |
4 | LYS621 |
4 | HOH4326 |
site_id | PC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 7021 |
Chain | Residue |
4 | ARG630 |
4 | SER632 |
4 | THR635 |
4 | GLU637 |
site_id | PC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS 4 7022 |
Chain | Residue |
4 | SER709 |
site_id | PC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 4 7023 |
Chain | Residue |
4 | TRP999 |
4 | DMS7025 |
site_id | PC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 7024 |
Chain | Residue |
4 | GLU508 |
4 | PRO1001 |
4 | VAL1003 |
4 | HOH4035 |
site_id | PC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 4 7025 |
Chain | Residue |
4 | ASN102 |
4 | ASP598 |
4 | PHE601 |
4 | GAI2001 |
4 | DMS7023 |
Functional Information from PROSITE/UniProt
site_id | PS00608 |
Number of Residues | 15 |
Details | GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DRNHPSVIIWSlg.NE |
Chain | Residue | Details |
1 | ASP447-GLU461 |
site_id | PS00719 |
Number of Residues | 26 |
Details | GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaVRCSHYPnhplWYtlcDryGLYVV |
Chain | Residue | Details |
1 | ASN385-VAL410 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:6420154 |
Chain | Residue | Details |
1 | GLU461 | |
2 | GLU461 | |
3 | GLU461 | |
4 | GLU461 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:1350782 |
Chain | Residue | Details |
1 | GLU537 | |
2 | GLU537 | |
3 | GLU537 | |
4 | GLU537 |
site_id | SWS_FT_FI3 |
Number of Residues | 28 |
Details | BINDING: |
Chain | Residue | Details |
2 | ASP201 | |
2 | GLU461 | |
2 | GLU537 | |
2 | PHE601 | |
2 | ASN604 | |
2 | TRP999 | |
3 | ASN102 | |
3 | ASP201 | |
3 | GLU461 | |
3 | GLU537 | |
3 | PHE601 | |
3 | ASN604 | |
3 | TRP999 | |
4 | ASN102 | |
4 | ASP201 | |
4 | GLU461 | |
4 | GLU537 | |
4 | PHE601 | |
4 | ASN604 | |
4 | TRP999 | |
1 | ASN102 | |
1 | ASP201 | |
1 | GLU461 | |
1 | GLU537 | |
1 | PHE601 | |
1 | ASN604 | |
1 | TRP999 | |
2 | ASN102 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11045615 |
Chain | Residue | Details |
1 | ASN597 | |
2 | ASN597 | |
3 | ASN597 | |
4 | ASN597 | |
1 | GLU416 | |
1 | HIS418 | |
2 | GLU416 | |
2 | HIS418 | |
3 | GLU416 | |
3 | HIS418 | |
4 | GLU416 | |
4 | HIS418 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | SITE: Transition state stabilizer |
Chain | Residue | Details |
3 | HIS357 | |
3 | HIS391 | |
4 | HIS357 | |
4 | HIS391 | |
1 | HIS357 | |
1 | HIS391 | |
2 | HIS357 | |
2 | HIS391 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | SITE: Important for ensuring that an appropriate proportion of lactose is converted to allolactose |
Chain | Residue | Details |
1 | TRP999 | |
2 | TRP999 | |
3 | TRP999 | |
4 | TRP999 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
1 | ASP201 | |
1 | HIS357 | |
1 | HIS391 | |
1 | GLU416 | |
1 | HIS418 | |
1 | GLU461 | |
1 | GLU537 | |
1 | ASN597 | |
1 | PHE601 | |
1 | ASN604 |
site_id | MCSA2 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
2 | GLU461 | |
2 | GLU537 | |
2 | ASN597 | |
2 | PHE601 | |
2 | ASN604 | |
2 | ASP201 | |
2 | HIS357 | |
2 | HIS391 | |
2 | GLU416 | |
2 | HIS418 |
site_id | MCSA3 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
3 | ASP201 | |
3 | HIS357 | |
3 | HIS391 | |
3 | GLU416 | |
3 | HIS418 | |
3 | GLU461 | |
3 | GLU537 | |
3 | ASN597 | |
3 | PHE601 | |
3 | ASN604 |
site_id | MCSA4 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
4 | ASP201 | |
4 | HIS357 | |
4 | HIS391 | |
4 | GLU416 | |
4 | HIS418 | |
4 | GLU461 | |
4 | GLU537 | |
4 | ASN597 | |
4 | PHE601 | |
4 | ASN604 |