Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3MV1

E.Coli (lacZ) beta-galactosidase (R599A) in complex with Guanidinium

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000287	molecular_function	magnesium ion binding
1	0003824	molecular_function	catalytic activity
1	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
1	0004565	molecular_function	beta-galactosidase activity
1	0005975	biological_process	carbohydrate metabolic process
1	0005990	biological_process	lactose catabolic process
1	0009341	cellular_component	beta-galactosidase complex
1	0016787	molecular_function	hydrolase activity
1	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
1	0030246	molecular_function	carbohydrate binding
1	0031420	molecular_function	alkali metal ion binding
1	0042802	molecular_function	identical protein binding
1	0046872	molecular_function	metal ion binding
2	0000287	molecular_function	magnesium ion binding
2	0003824	molecular_function	catalytic activity
2	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
2	0004565	molecular_function	beta-galactosidase activity
2	0005975	biological_process	carbohydrate metabolic process
2	0005990	biological_process	lactose catabolic process
2	0009341	cellular_component	beta-galactosidase complex
2	0016787	molecular_function	hydrolase activity
2	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
2	0030246	molecular_function	carbohydrate binding
2	0031420	molecular_function	alkali metal ion binding
2	0042802	molecular_function	identical protein binding
2	0046872	molecular_function	metal ion binding
3	0000287	molecular_function	magnesium ion binding
3	0003824	molecular_function	catalytic activity
3	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
3	0004565	molecular_function	beta-galactosidase activity
3	0005975	biological_process	carbohydrate metabolic process
3	0005990	biological_process	lactose catabolic process
3	0009341	cellular_component	beta-galactosidase complex
3	0016787	molecular_function	hydrolase activity
3	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
3	0030246	molecular_function	carbohydrate binding
3	0031420	molecular_function	alkali metal ion binding
3	0042802	molecular_function	identical protein binding
3	0046872	molecular_function	metal ion binding
4	0000287	molecular_function	magnesium ion binding
4	0003824	molecular_function	catalytic activity
4	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
4	0004565	molecular_function	beta-galactosidase activity
4	0005975	biological_process	carbohydrate metabolic process
4	0005990	biological_process	lactose catabolic process
4	0009341	cellular_component	beta-galactosidase complex
4	0016787	molecular_function	hydrolase activity
4	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
4	0030246	molecular_function	carbohydrate binding
4	0031420	molecular_function	alkali metal ion binding
4	0042802	molecular_function	identical protein binding
4	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 1 3001

Chain	Residue
1	GLU416
1	HIS418
1	GLU461
1	HOH4012
1	HOH4076
1	HOH4152

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG 1 3002

Chain	Residue
1	GLN163
1	ASP193
1	ASP15
1	ASN18
1	VAL21

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG 1 3004

Chain	Residue
1	GLN718
1	THR911
1	HOH4256
1	HOH4362
1	HOH4559
1	HOH4600
1	HOH4810

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA 1 3101

Chain	Residue
1	ASP201
1	PHE601
1	ASN604
1	HOH4266
1	HOH4928

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 1 3102

Chain	Residue
1	PHE556
1	TYR559
1	PRO560
1	LEU562
1	HOH4384
1	HOH4561

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA 1 3103

Chain	Residue
1	PHE931
1	PRO932
1	LEU967
1	MET968
1	THR970
1	HOH4200
1	HOH4492

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 1 3104

Chain	Residue
1	SER647
1	ASP648
1	ASN649
1	GLU650
1	LEU670
1	HOH4634

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GAI 1 2001

Chain	Residue
1	ASP598
1	PHE601
1	GLU797

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS 1 7000

Chain	Residue
1	THR229
1	VAL330
1	GLY331
1	ASN449
1	PRO451
1	ARG482
1	HOH4009

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7001

Chain	Residue
1	ARG557
1	HIS622
1	GLN628
1	HOH4198

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 1 7002

Chain	Residue
1	LYS380
1	ASN383
1	PHE626
1	TYR642
1	TRP708
1	HOH4207

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 1 7003

Chain	Residue
1	PRO32
1	PHE33
1	TRP36
1	ALA327
1	HOH4395
1	HOH4893

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 7004

Chain	Residue
1	THR271
1	LEU291
1	ARG292

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 1 7005

Chain	Residue
1	GLU314
1	GLY320

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 1 7006

Chain	Residue
1	ARG505
1	GLU508
1	PRO1001
1	SER1002
1	VAL1003
1	HOH4035

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7007

Chain	Residue
1	VAL335
1	ARG336
1	PRO480
1	HOH4205

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7008

Chain	Residue
1	PRO584
1	SER586
1	ARG973
1	HOH4099

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7009

Chain	Residue
1	GLY275
1	VAL289
1	THR290
1	ARG292

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 7010

Chain	Residue
1	VAL84
1	VAL85
1	HIS93

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 7011

Chain	Residue
1	TYR105
1	PRO106
1	THR108

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 1 7012

Chain	Residue
1	HIS93
1	GLY94

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7013

Chain	Residue
1	TRP36
1	ASP45
1	ARG46
1	PRO47

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7014

Chain	Residue
1	PHE629
1	GLN718
1	TRP720
1	HOH4229

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 7015

Chain	Residue
1	ARG37
1	GLN50
1	HIS216

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7016

Chain	Residue
1	GLN266
1	VAL267
1	ALA268
1	SER269

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7017

Chain	Residue
1	ARG230
1	PHE231
1	ARG237
1	VAL239

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 7018

Chain	Residue
1	TYR472
1	THR494
1	THR496

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7019

Chain	Residue
1	ARG630
1	SER632
1	THR635
1	GLU637

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7020

Chain	Residue
1	ILE737
1	GLU750
1	LEU751
1	GLY752

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 7021

Chain	Residue
1	ALA707
1	TRP708
1	SER709
1	GLU710

site_id	DC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMS 1 7022

Chain	Residue
1	HIS418

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 7023

Chain	Residue
1	LEU54
1	ASN55
1	LEU125

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 1 7024

Chain	Residue
1	GLU57
1	ARG59
1	LEU125
1	THR126
1	HOH4839

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 2 3001

Chain	Residue
2	GLU416
2	HIS418
2	GLU461
2	HOH4012
2	HOH4076
2	HOH4152

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG 2 3002

Chain	Residue
2	ASP15
2	ASN18
2	VAL21
2	GLN163
2	ASP193

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 2 3004

Chain	Residue
2	GLN718
2	THR911
2	HOH4259
2	HOH4584
2	HOH4640
2	HOH4828

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA 2 3101

Chain	Residue
2	ASP201
2	PHE601
2	ASN604
2	HOH4269
2	HOH4993

site_id	EC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 2 3102

Chain	Residue
2	PHE556
2	TYR559
2	PRO560
2	LEU562
2	HOH4386
2	HOH4587

site_id	EC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 2 3103

Chain	Residue
2	PHE931
2	PRO932
2	LEU967
2	THR970
2	HOH4202
2	HOH4671

site_id	EC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA 2 3104

Chain	Residue
2	SER647
2	GLU650
2	LEU670
2	HOH5067
2	DMS7016

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GAI 2 2001

Chain	Residue
2	ASP598
2	PHE601
2	GLU797

site_id	EC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS 2 7000

Chain	Residue
2	THR229
2	VAL330
2	GLY331
2	ASN449
2	PRO451
2	ARG482
2	HOH4009

site_id	EC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 7001

Chain	Residue
2	ARG557
2	HIS622
2	GLN623
2	GLN628
2	HOH4200

site_id	EC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 2 7002

Chain	Residue
2	LYS380
2	ASN383
2	PHE626
2	TYR642
2	TRP708
2	HOH4209

site_id	EC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 7003

Chain	Residue
2	PRO32
2	PHE33
2	TRP36
2	ALA327
2	HOH4398

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 7004

Chain	Residue
2	THR271
2	LEU291
2	ARG292
2	HOH4642

site_id	FC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 7005

Chain	Residue
1	HOH4548
2	THR257
2	GLU314
2	HIS316
2	GLY320

site_id	FC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 2 7006

Chain	Residue
2	GLU334
2	VAL335
2	PRO480
2	HOH4204
2	HOH4207
2	HOH4488

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7007

Chain	Residue
2	ILE99
2	PRO106
2	HOH4257

site_id	FC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7008

Chain	Residue
2	TRP585
2	SER586
2	ARG973

site_id	FC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 7009

Chain	Residue
2	GLY275
2	VAL289
2	THR290
2	ARG292
2	HOH4762

site_id	FC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7010

Chain	Residue
2	THR83
2	VAL85
2	HIS93

site_id	FC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7011

Chain	Residue
2	LEU250
2	ARG251
2	ASP252

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 7012

Chain	Residue
2	PHE231
2	ASN232
2	ASP233
2	GLU334

site_id	GC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 7013

Chain	Residue
2	ASP428
2	PRO430
2	HOH4456
3	VAL478

site_id	GC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 2 7014

Chain	Residue
2	HIS93
2	GLY94

site_id	GC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7015

Chain	Residue
2	TYR926
2	TYR962
2	ARG973

site_id	GC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 7016

Chain	Residue
2	ASP648
2	ASN649
2	GLU650
2	NA3104

site_id	GC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 7017

Chain	Residue
2	ARG37
2	GLN50
2	SER132
2	TRP133

site_id	GC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7018

Chain	Residue
2	SER923
2	ARG961
2	TYR962

site_id	GC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 7019

Chain	Residue
2	VAL267
2	ASN294
2	VAL295
2	GLU296

site_id	GC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7020

Chain	Residue
2	GLU369
2	LEU401
2	ARG404

site_id	GC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 2 7021

Chain	Residue
2	ARG404
2	TYR405

site_id	HC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 2 7022

Chain	Residue
2	PRO306
2	ASN307

site_id	HC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7023

Chain	Residue
2	THR706
2	SER709
2	GLU710

site_id	HC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 2 7024

Chain	Residue
2	ARG630
2	SER632

site_id	HC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 7025

Chain	Residue
2	TYR105
2	PRO106
2	THR108
2	HOH4449

site_id	HC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 2 7026

Chain	Residue
2	ASP45
2	HOH4594

site_id	HC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7027

Chain	Residue
2	ASN102
2	TRP999
2	HOH4819

site_id	HC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7028

Chain	Residue
2	GLN49
3	SER48
3	LEU51

site_id	HC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 7029

Chain	Residue
2	LEU54
2	ASN55
2	LEU125

site_id	HC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 3 3001

Chain	Residue
3	GLU416
3	HIS418
3	GLU461
3	HOH4013
3	HOH4076
3	HOH4154

site_id	IC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG 3 3002

Chain	Residue
3	ASP15
3	ASN18
3	VAL21
3	GLN163
3	ASP193

site_id	IC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 3 3004

Chain	Residue
3	GLN718
3	HOH4258
3	HOH4375
3	HOH4638
3	HOH4868
3	HOH4921

site_id	IC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA 3 3101

Chain	Residue
3	ASP201
3	PHE601
3	ASN604
3	HOH4268
3	HOH4986

site_id	IC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 3 3102

Chain	Residue
3	PHE556
3	TYR559
3	PRO560
3	LEU562
3	HOH4388
3	HOH4591

site_id	IC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 3 3103

Chain	Residue
3	PHE931
3	PRO932
3	LEU967
3	THR970
3	HOH4202
3	HOH4664

site_id	IC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA 3 3104

Chain	Residue
3	SER647
3	GLU650
3	LEU670
3	DMS7016

site_id	IC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GAI 3 2001

Chain	Residue
3	ASP598
3	VAL795
3	GLU797

site_id	IC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS 3 7000

Chain	Residue
3	THR229
3	VAL330
3	GLY331
3	ARG448
3	ASN449
3	ARG482
3	HOH4010

site_id	IC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 7001

Chain	Residue
3	ARG557
3	HIS622
3	GLN623
3	GLN628
3	HOH4200

site_id	JC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 3 7002

Chain	Residue
3	LYS380
3	ASN383
3	PHE626
3	TYR642
3	TRP708
3	HOH4209

site_id	JC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 7003

Chain	Residue
3	PRO32
3	PHE33
3	TRP36
3	ALA327
3	HOH4401

site_id	JC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 7004

Chain	Residue
3	THR271
3	LEU291
3	ARG292
3	HOH4992

site_id	JC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 7005

Chain	Residue
3	GLU508
3	PRO1001
3	VAL1003
3	HOH4036

site_id	JC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 7006

Chain	Residue
3	PRO480
3	HOH4204
3	HOH4207

site_id	JC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMS 3 7007

Chain	Residue
3	PRO106

site_id	JC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 7008

Chain	Residue
3	ILE576
3	TRP585
3	SER586
3	ARG973
3	HOH4100

site_id	JC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 7009

Chain	Residue
3	GLY275
3	GLY276
3	VAL289
3	THR290
3	ARG292

site_id	JC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 7010

Chain	Residue
3	VAL84
3	VAL85
3	HIS93

site_id	KC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 7011

Chain	Residue
3	LYS621
3	ILE714
3	HOH4323
3	DMS7025

site_id	KC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 7012

Chain	Residue
3	LEU250
3	ARG251
3	ASP252

site_id	KC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 7013

Chain	Residue
2	HOH4406
3	ASP428
3	PRO430

site_id	KC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 3 7014

Chain	Residue
3	HIS93
3	GLY94

site_id	KC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 7015

Chain	Residue
2	ASN581
3	TYR926
3	TYR962
3	ARG973

site_id	KC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 7016

Chain	Residue
3	ASN649
3	GLU650
3	ASN704
3	NA3104

site_id	KC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS 3 7017

Chain	Residue
3	TRP36
3	ASP45
3	ARG46
3	PRO47
3	SER48
3	HOH4480
3	HOH4705

site_id	KC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 7018

Chain	Residue
3	GLN266
3	VAL267
3	ALA268
4	LEU740
4	THR742

site_id	KC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 7019

Chain	Residue
3	TYR105
3	PRO106
3	ILE107
3	THR108

site_id	LC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 7020

Chain	Residue
3	ARG630
3	SER632
3	THR635
3	GLU637

site_id	LC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 7021

Chain	Residue
3	THR706
3	ALA707
3	TRP708
3	SER709
3	GLU710

site_id	LC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 3 7022

Chain	Residue
3	ARG404
3	TYR405

site_id	LC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 7023

Chain	Residue
3	GLU314
3	HIS316
3	GLY320

site_id	LC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 7024

Chain	Residue
3	ARG37
3	SER132
3	TRP133
3	GLU136
3	HIS216

site_id	LC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 7025

Chain	Residue
3	ILE714
3	TRP717
3	HOH4892
3	DMS7011

site_id	LC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 3 7026

Chain	Residue
3	ASN102
3	HIS418

site_id	LC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 1024

Chain	Residue
3	LEU54
3	ASN55
3	LEU125

site_id	LC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 4 3001

Chain	Residue
4	GLU416
4	HIS418
4	GLU461
4	HOH4012
4	HOH4076
4	HOH4153

site_id	MC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG 4 3002

Chain	Residue
4	ASP15
4	ASN18
4	VAL21
4	GLN163
4	ASP193

site_id	MC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG 4 3004

Chain	Residue
4	GLN718
4	THR911
4	HOH4260
4	HOH4567
4	HOH4611

site_id	MC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA 4 3101

Chain	Residue
4	ASP201
4	PHE601
4	ASN604
4	HOH4270

site_id	MC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 4 3102

Chain	Residue
4	PHE556
4	TYR559
4	PRO560
4	LEU562
4	HOH4389
4	HOH4570

site_id	MC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NA 4 3103

Chain	Residue
4	PHE931
4	PRO932
4	LEU967
4	MET968
4	THR970
4	HOH4203
4	HOH4506
4	HOH4640

site_id	MC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 4 3104

Chain	Residue
4	SER647
4	ASP648
4	ASN649
4	GLU650
4	LEU670
4	HOH4755

site_id	MC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GAI 4 2001

Chain	Residue
4	ASP598
4	PHE601
4	VAL795
4	GLU797
4	DMS7025

site_id	MC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS 4 7000

Chain	Residue
4	THR229
4	VAL330
4	GLY331
4	ASN449
4	PRO451
4	ARG482
4	HOH4009

site_id	MC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 4 7001

Chain	Residue
4	ARG557
4	HIS622
4	GLN623
4	GLN625
4	GLN628

site_id	NC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 4 7002

Chain	Residue
4	LYS380
4	ASN383
4	PHE626
4	TYR642
4	TRP708
4	HOH4210

site_id	NC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS 4 7003

Chain	Residue
4	PRO32
4	PHE33
4	TRP36
4	ALA327
4	HOH4401
4	HOH4461
4	HOH4839
4	DMS7015

site_id	NC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 7004

Chain	Residue
4	THR271
4	LEU291
4	ARG292

site_id	NC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 7005

Chain	Residue
4	GLU314
4	HIS316
4	GLY320

site_id	NC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 7006

Chain	Residue
4	VAL335
4	PRO480
4	HOH4208

site_id	NC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 4 7007

Chain	Residue
4	GLU117
4	HOH4355

site_id	NC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 4 7008

Chain	Residue
4	PRO584
4	TRP585
4	SER586
4	ARG973
4	HOH4100

site_id	NC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 7009

Chain	Residue
4	GLY275
4	THR290
4	ARG292
4	HOH4549

site_id	NC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 7010

Chain	Residue
4	THR83
4	VAL84
4	VAL85
4	HIS93

site_id	OC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 7011

Chain	Residue
4	LEU250
4	ARG251
4	ASP252

site_id	OC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 7012

Chain	Residue
4	TYR105
4	PRO106
4	THR108

site_id	OC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 4 7013

Chain	Residue
4	HIS93
4	GLY94

site_id	OC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 7014

Chain	Residue
4	TYR926
4	TYR962
4	ARG973
4	LEU976

site_id	OC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS 4 7015

Chain	Residue
4	ALA34
4	TRP36
4	ASP45
4	ARG46
4	PRO47
4	HOH4475
4	DMS7003

site_id	OC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 7016

Chain	Residue
4	PHE629
4	GLN718
4	TRP720
4	HOH4234

site_id	OC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 7017

Chain	Residue
4	SER923
4	TYR926
4	TYR962
4	HOH4109

site_id	OC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 7018

Chain	Residue
4	LEU134
4	GLN135
4	SER174

site_id	OC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 7019

Chain	Residue
4	ILE737
4	GLU750
4	LEU751
4	GLY752

site_id	PC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 4 7020

Chain	Residue
4	LYS621
4	HOH4326

site_id	PC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 7021

Chain	Residue
4	ARG630
4	SER632
4	THR635
4	GLU637

site_id	PC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMS 4 7022

Chain	Residue
4	SER709

site_id	PC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 4 7023

Chain	Residue
4	TRP999
4	DMS7025

site_id	PC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 7024

Chain	Residue
4	GLU508
4	PRO1001
4	VAL1003
4	HOH4035

site_id	PC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 4 7025

Chain	Residue
4	ASN102
4	ASP598
4	PHE601
4	GAI2001
4	DMS7023

Functional Information from PROSITE/UniProt

site_id	PS00608
Number of Residues	15
Details	GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DRNHPSVIIWSlg.NE

Chain	Residue	Details
1	ASP447-GLU461

site_id	PS00719
Number of Residues	26
Details	GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaVRCSHYPnhplWYtlcDryGLYVV

Chain	Residue	Details
1	ASN385-VAL410

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"6420154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"1350782","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11045615","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Important for ensuring that an appropriate proportion of lactose is converted to allolactose"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	10
Details	M-CSA 422

Chain

Residue

Details

site_id	MCSA2
Number of Residues	10
Details	M-CSA 422

Chain

Residue

Details

site_id	MCSA3
Number of Residues	10
Details	M-CSA 422

Chain

Residue

Details

site_id	MCSA4
Number of Residues	10
Details	M-CSA 422

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)