3MUY
E. coli (lacZ) beta-galactosidase (R599A)
Functional Information from GO Data
Chain | GOid | namespace | contents |
1 | 0000287 | molecular_function | magnesium ion binding |
1 | 0003824 | molecular_function | catalytic activity |
1 | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
1 | 0004565 | molecular_function | beta-galactosidase activity |
1 | 0005975 | biological_process | carbohydrate metabolic process |
1 | 0005990 | biological_process | lactose catabolic process |
1 | 0009056 | biological_process | catabolic process |
1 | 0009341 | cellular_component | beta-galactosidase complex |
1 | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
1 | 0030246 | molecular_function | carbohydrate binding |
1 | 0031420 | molecular_function | alkali metal ion binding |
1 | 0042802 | molecular_function | identical protein binding |
1 | 0046872 | molecular_function | metal ion binding |
2 | 0000287 | molecular_function | magnesium ion binding |
2 | 0003824 | molecular_function | catalytic activity |
2 | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
2 | 0004565 | molecular_function | beta-galactosidase activity |
2 | 0005975 | biological_process | carbohydrate metabolic process |
2 | 0005990 | biological_process | lactose catabolic process |
2 | 0009056 | biological_process | catabolic process |
2 | 0009341 | cellular_component | beta-galactosidase complex |
2 | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
2 | 0030246 | molecular_function | carbohydrate binding |
2 | 0031420 | molecular_function | alkali metal ion binding |
2 | 0042802 | molecular_function | identical protein binding |
2 | 0046872 | molecular_function | metal ion binding |
3 | 0000287 | molecular_function | magnesium ion binding |
3 | 0003824 | molecular_function | catalytic activity |
3 | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
3 | 0004565 | molecular_function | beta-galactosidase activity |
3 | 0005975 | biological_process | carbohydrate metabolic process |
3 | 0005990 | biological_process | lactose catabolic process |
3 | 0009056 | biological_process | catabolic process |
3 | 0009341 | cellular_component | beta-galactosidase complex |
3 | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
3 | 0030246 | molecular_function | carbohydrate binding |
3 | 0031420 | molecular_function | alkali metal ion binding |
3 | 0042802 | molecular_function | identical protein binding |
3 | 0046872 | molecular_function | metal ion binding |
4 | 0000287 | molecular_function | magnesium ion binding |
4 | 0003824 | molecular_function | catalytic activity |
4 | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
4 | 0004565 | molecular_function | beta-galactosidase activity |
4 | 0005975 | biological_process | carbohydrate metabolic process |
4 | 0005990 | biological_process | lactose catabolic process |
4 | 0009056 | biological_process | catabolic process |
4 | 0009341 | cellular_component | beta-galactosidase complex |
4 | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
4 | 0030246 | molecular_function | carbohydrate binding |
4 | 0031420 | molecular_function | alkali metal ion binding |
4 | 0042802 | molecular_function | identical protein binding |
4 | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS 1 8401 |
Chain | Residue |
1 | THR229 |
1 | VAL330 |
1 | GLY331 |
1 | ASN449 |
1 | PRO451 |
1 | ARG482 |
1 | HOH4011 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 8402 |
Chain | Residue |
1 | GLN628 |
1 | HOH4205 |
1 | ARG557 |
1 | HIS622 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 1 8403 |
Chain | Residue |
1 | LYS380 |
1 | ASN383 |
1 | PHE626 |
1 | TYR642 |
1 | TRP708 |
1 | HOH4214 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 1 8404 |
Chain | Residue |
1 | PRO32 |
1 | PHE33 |
1 | TRP36 |
1 | ASP45 |
1 | ALA327 |
1 | DMS8501 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 8405 |
Chain | Residue |
1 | THR271 |
1 | LEU291 |
1 | ARG292 |
1 | HOH4724 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 8406 |
Chain | Residue |
1 | HIS316 |
1 | GLY320 |
1 | LEU322 |
1 | MG3003 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 8407 |
Chain | Residue |
1 | ARG505 |
1 | GLU508 |
1 | PRO1001 |
1 | HOH4037 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 1 8408 |
Chain | Residue |
1 | LEU54 |
1 | ASN55 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 1 8409 |
Chain | Residue |
1 | GLU334 |
1 | VAL335 |
1 | ARG336 |
1 | PRO480 |
1 | HOH4525 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 1 8411 |
Chain | Residue |
1 | ILE576 |
1 | PRO584 |
1 | TRP585 |
1 | SER586 |
1 | ARG973 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 1 8412 |
Chain | Residue |
1 | GLY275 |
1 | GLU277 |
1 | VAL289 |
1 | THR290 |
1 | ARG292 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 8414 |
Chain | Residue |
1 | THR83 |
1 | VAL85 |
1 | HIS93 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 8416 |
Chain | Residue |
1 | ARG251 |
1 | ASP252 |
4 | ARG251 |
site_id | BC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS 1 8419 |
Chain | Residue |
1 | PRO596 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 8421 |
Chain | Residue |
1 | HIS93 |
1 | GLY94 |
1 | TYR95 |
site_id | BC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DMS 1 8425 |
Chain | Residue |
1 | SER647 |
1 | ASP648 |
1 | ASN649 |
1 | GLU650 |
1 | PRO703 |
1 | ASN704 |
1 | NA3103 |
3 | LYS1023 |
site_id | BC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 1 8501 |
Chain | Residue |
1 | HOH4318 |
1 | DMS8404 |
site_id | BC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 8503 |
Chain | Residue |
1 | PHE629 |
1 | GLN718 |
1 | TRP720 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 8504 |
Chain | Residue |
1 | SER132 |
1 | TRP133 |
1 | GLU136 |
1 | HIS216 |
site_id | CC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 1 8602 |
Chain | Residue |
1 | GLN266 |
1 | VAL267 |
site_id | CC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 1 3001 |
Chain | Residue |
1 | GLU416 |
1 | HIS418 |
1 | GLU461 |
1 | HOH4014 |
1 | HOH4078 |
1 | HOH4156 |
site_id | CC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG 1 3002 |
Chain | Residue |
1 | ASP15 |
1 | ASN18 |
1 | VAL21 |
1 | GLN163 |
1 | ASP193 |
site_id | CC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 1 3003 |
Chain | Residue |
1 | HOH4674 |
1 | HOH5163 |
1 | HOH5173 |
1 | HOH7562 |
1 | DMS8406 |
4 | DMS8703 |
site_id | CC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 1 3101 |
Chain | Residue |
1 | PHE601 |
1 | ASN604 |
1 | HOH4278 |
1 | HOH7547 |
1 | HOH7560 |
1 | ASP201 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 1 3102 |
Chain | Residue |
1 | PHE556 |
1 | TYR559 |
1 | PRO560 |
1 | LEU562 |
1 | HOH4410 |
1 | HOH4652 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA 1 3103 |
Chain | Residue |
1 | SER647 |
1 | GLU650 |
1 | LEU670 |
1 | DMS8425 |
site_id | CC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 1 8603 |
Chain | Residue |
1 | ARG404 |
1 | TYR405 |
site_id | DC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS 1 8604 |
Chain | Residue |
1 | GLU744 |
site_id | DC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 8605 |
Chain | Residue |
1 | GLY248 |
1 | GLU249 |
1 | LEU250 |
1 | ARG251 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 1 8606 |
Chain | Residue |
1 | ASN38 |
1 | SER39 |
1 | LEU322 |
1 | HOH4691 |
4 | GLN49 |
site_id | DC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 1 8607 |
Chain | Residue |
1 | TYR472 |
1 | THR494 |
1 | THR496 |
site_id | DC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 1 8609 |
Chain | Residue |
1 | GLU57 |
1 | TRP58 |
1 | ARG59 |
1 | THR126 |
site_id | DC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS 2 8401 |
Chain | Residue |
2 | THR229 |
2 | VAL330 |
2 | GLY331 |
2 | ASN449 |
2 | PRO451 |
2 | ARG482 |
2 | HOH4011 |
site_id | DC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 8402 |
Chain | Residue |
2 | ARG557 |
2 | HIS622 |
2 | GLN623 |
2 | GLN628 |
site_id | DC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 2 8403 |
Chain | Residue |
2 | LYS380 |
2 | ASN383 |
2 | PHE626 |
2 | TYR642 |
2 | TRP708 |
2 | HOH4214 |
site_id | DC9 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE DMS 2 8404 |
Chain | Residue |
2 | PRO32 |
2 | PHE33 |
2 | ALA34 |
2 | TRP36 |
2 | ASP45 |
2 | ARG310 |
2 | ALA327 |
2 | HOH4423 |
2 | DMS8606 |
site_id | EC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 8405 |
Chain | Residue |
2 | GLY270 |
2 | THR271 |
2 | LEU291 |
2 | ARG292 |
2 | HOH4724 |
site_id | EC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 8406 |
Chain | Residue |
2 | GLU314 |
2 | HIS316 |
2 | GLY320 |
2 | THR321 |
2 | LEU322 |
site_id | EC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 8408 |
Chain | Residue |
2 | SER53 |
2 | LEU54 |
2 | ASN55 |
2 | LEU125 |
site_id | EC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 2 8409 |
Chain | Residue |
2 | GLU334 |
2 | VAL335 |
2 | ARG336 |
2 | PRO480 |
2 | HOH4209 |
2 | HOH4212 |
site_id | EC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 8410 |
Chain | Residue |
2 | PRO106 |
2 | HOH4371 |
2 | DMS8605 |
site_id | EC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 8411 |
Chain | Residue |
2 | ILE576 |
2 | PRO584 |
2 | TRP585 |
2 | SER586 |
2 | ARG973 |
site_id | EC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 8412 |
Chain | Residue |
2 | GLY275 |
2 | VAL289 |
2 | THR290 |
2 | ARG292 |
site_id | EC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 8414 |
Chain | Residue |
2 | VAL84 |
2 | VAL85 |
2 | HIS93 |
site_id | EC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 8416 |
Chain | Residue |
2 | LEU250 |
2 | ARG251 |
2 | ASP252 |
site_id | FC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 8417 |
Chain | Residue |
2 | PHE231 |
2 | ASN232 |
2 | GLU334 |
2 | ARG336 |
site_id | FC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 8420 |
Chain | Residue |
2 | ASP428 |
3 | ARG448 |
3 | VAL478 |
site_id | FC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 8421 |
Chain | Residue |
2 | HIS93 |
2 | GLY94 |
2 | TYR95 |
site_id | FC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 8423 |
Chain | Residue |
2 | TYR926 |
2 | TYR962 |
2 | ARG973 |
site_id | FC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 8425 |
Chain | Residue |
2 | ASP648 |
2 | ASN649 |
2 | GLU650 |
2 | ASN704 |
2 | NA3102 |
site_id | FC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 8502 |
Chain | Residue |
2 | GLU57 |
2 | LEU125 |
2 | THR126 |
2 | HOH4539 |
site_id | FC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 8504 |
Chain | Residue |
2 | ARG37 |
2 | GLN50 |
2 | SER132 |
2 | TRP133 |
2 | HIS216 |
site_id | FC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 8508 |
Chain | Residue |
2 | SER923 |
2 | TYR926 |
2 | TYR962 |
site_id | FC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 8601 |
Chain | Residue |
2 | VAL267 |
2 | ASN294 |
2 | VAL295 |
2 | GLU296 |
site_id | GC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 2 3001 |
Chain | Residue |
2 | GLU416 |
2 | HIS418 |
2 | GLU461 |
2 | HOH4014 |
2 | HOH4078 |
2 | HOH4156 |
site_id | GC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG 2 3002 |
Chain | Residue |
2 | ASP15 |
2 | ASN18 |
2 | VAL21 |
2 | GLN163 |
2 | ASP193 |
site_id | GC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 2 3101 |
Chain | Residue |
2 | PHE556 |
2 | TYR559 |
2 | PRO560 |
2 | LEU562 |
2 | HOH4410 |
2 | HOH4652 |
site_id | GC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA 2 3102 |
Chain | Residue |
2 | SER647 |
2 | GLU650 |
2 | LEU670 |
2 | DMS8425 |
site_id | GC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA 2 3103 |
Chain | Residue |
2 | PHE931 |
2 | PRO932 |
2 | LEU967 |
2 | THR970 |
2 | HOH4207 |
site_id | GC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA 2 3104 |
Chain | Residue |
2 | ASP201 |
2 | PHE601 |
2 | ASN604 |
2 | HOH4278 |
2 | HOH7560 |
site_id | GC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 8602 |
Chain | Residue |
2 | PHE231 |
2 | ASN232 |
2 | ARG237 |
2 | ALA238 |
site_id | GC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 8603 |
Chain | Residue |
2 | ASN102 |
2 | ASP598 |
2 | PHE601 |
2 | VAL795 |
site_id | GC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 2 8604 |
Chain | Residue |
2 | ARG404 |
2 | TYR405 |
site_id | HC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 8605 |
Chain | Residue |
2 | TYR105 |
2 | PRO106 |
2 | PRO596 |
2 | HOH4481 |
2 | DMS8410 |
site_id | HC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 8606 |
Chain | Residue |
2 | ASP45 |
2 | ARG46 |
2 | PRO47 |
2 | DMS8404 |
site_id | HC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 2 8607 |
Chain | Residue |
2 | PRO306 |
2 | ASN307 |
site_id | HC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 2 8608 |
Chain | Residue |
2 | LEU250 |
3 | ARG425 |
site_id | HC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 2 8609 |
Chain | Residue |
2 | SER963 |
2 | GLN965 |
2 | GLU969 |
2 | HIS977 |
2 | GLU979 |
2 | HOH4310 |
site_id | HC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 8610 |
Chain | Residue |
2 | TYR472 |
2 | THR494 |
2 | THR496 |
2 | ASP497 |
2 | HOH4681 |
site_id | HC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 2 8611 |
Chain | Residue |
2 | GLN783 |
2 | PHE784 |
2 | THR785 |
2 | HIS815 |
2 | TRP842 |
site_id | HC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 2 8612 |
Chain | Residue |
2 | PHE989 |
2 | ARG1013 |
2 | TYR1014 |
2 | HIS1015 |
site_id | HC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 2 8613 |
Chain | Residue |
1 | LEU740 |
1 | THR742 |
2 | GLN266 |
site_id | IC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 3 8401 |
Chain | Residue |
3 | THR229 |
3 | GLY331 |
3 | ASN449 |
3 | PRO451 |
3 | ARG482 |
3 | HOH4011 |
site_id | IC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8402 |
Chain | Residue |
3 | ARG557 |
3 | HIS622 |
3 | GLN623 |
3 | GLN628 |
site_id | IC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 3 8403 |
Chain | Residue |
3 | LYS380 |
3 | ASN383 |
3 | PHE626 |
3 | TYR642 |
3 | TRP708 |
3 | HOH4214 |
site_id | IC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS 3 8404 |
Chain | Residue |
3 | PRO32 |
3 | PHE33 |
3 | TRP36 |
3 | ASP45 |
3 | ALA327 |
3 | HOH4423 |
3 | DMS8501 |
site_id | IC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 8405 |
Chain | Residue |
3 | GLY270 |
3 | THR271 |
3 | LEU291 |
3 | ARG292 |
3 | HOH4724 |
site_id | IC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 8407 |
Chain | Residue |
3 | ARG505 |
3 | GLU508 |
3 | PRO1001 |
site_id | IC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8408 |
Chain | Residue |
3 | SER53 |
3 | LEU54 |
3 | ASN55 |
3 | HOH4764 |
site_id | IC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8409 |
Chain | Residue |
3 | GLU334 |
3 | VAL335 |
3 | ARG336 |
3 | HOH4212 |
site_id | IC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 8410 |
Chain | Residue |
3 | PRO106 |
3 | HOH4371 |
3 | DMS8605 |
site_id | JC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 8411 |
Chain | Residue |
3 | ILE576 |
3 | PRO584 |
3 | TRP585 |
3 | SER586 |
3 | ARG973 |
site_id | JC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8412 |
Chain | Residue |
3 | GLY275 |
3 | VAL289 |
3 | THR290 |
3 | ARG292 |
site_id | JC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 8414 |
Chain | Residue |
3 | VAL84 |
3 | VAL85 |
3 | HIS93 |
site_id | JC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 8415 |
Chain | Residue |
3 | LYS621 |
3 | TRP717 |
3 | HOH4339 |
site_id | JC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 8416 |
Chain | Residue |
3 | LEU250 |
3 | ARG251 |
3 | ASP252 |
site_id | JC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8417 |
Chain | Residue |
3 | PHE231 |
3 | ASN232 |
3 | ASP233 |
3 | GLU334 |
site_id | JC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 3 8420 |
Chain | Residue |
2 | VAL478 |
3 | ASP428 |
site_id | JC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 8421 |
Chain | Residue |
3 | HIS93 |
3 | GLY94 |
3 | TYR95 |
site_id | JC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 3 8423 |
Chain | Residue |
3 | TYR926 |
3 | ARG973 |
site_id | KC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8425 |
Chain | Residue |
3 | ASP648 |
3 | GLU650 |
3 | ASN704 |
3 | NA3104 |
site_id | KC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 3 8428 |
Chain | Residue |
3 | ASN102 |
3 | DMS8602 |
site_id | KC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 8501 |
Chain | Residue |
3 | HOH4318 |
3 | HOH4512 |
3 | DMS8404 |
site_id | KC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8601 |
Chain | Residue |
3 | VAL267 |
3 | ASN294 |
3 | VAL295 |
3 | GLU296 |
site_id | KC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 3 3001 |
Chain | Residue |
3 | GLU416 |
3 | HIS418 |
3 | GLU461 |
3 | HOH4014 |
3 | HOH4078 |
3 | HOH4156 |
site_id | KC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG 3 3002 |
Chain | Residue |
3 | ASP15 |
3 | ASN18 |
3 | VAL21 |
3 | GLN163 |
3 | ASP193 |
site_id | KC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA 3 3101 |
Chain | Residue |
3 | ASP201 |
3 | PHE601 |
3 | ASN604 |
3 | HOH4278 |
3 | HOH7575 |
site_id | KC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 3 3102 |
Chain | Residue |
3 | PHE556 |
3 | TYR559 |
3 | PRO560 |
3 | LEU562 |
3 | HOH4410 |
3 | HOH4652 |
site_id | KC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 3 3103 |
Chain | Residue |
3 | PHE931 |
3 | PRO932 |
3 | LEU967 |
3 | MET968 |
3 | THR970 |
3 | HOH4207 |
site_id | LC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA 3 3104 |
Chain | Residue |
3 | SER647 |
3 | GLU650 |
3 | LEU670 |
3 | HOH5010 |
3 | DMS8425 |
site_id | LC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA 3 3105 |
Chain | Residue |
3 | HOH4476 |
3 | HOH5106 |
3 | HOH7509 |
site_id | LC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 8602 |
Chain | Residue |
3 | ASN102 |
3 | ASP598 |
3 | PHE601 |
3 | VAL795 |
3 | DMS8428 |
site_id | LC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 3 8603 |
Chain | Residue |
3 | GLN266 |
3 | VAL267 |
3 | ALA268 |
3 | SER269 |
4 | LEU740 |
4 | THR742 |
site_id | LC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8604 |
Chain | Residue |
3 | ALA61 |
3 | TRP62 |
3 | GLU80 |
3 | ASP82 |
site_id | LC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 3 8605 |
Chain | Residue |
3 | PRO106 |
3 | DMS8410 |
site_id | LC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8606 |
Chain | Residue |
3 | TYR472 |
3 | THR494 |
3 | THR496 |
3 | ASP497 |
site_id | LC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 8607 |
Chain | Residue |
3 | TRP695 |
3 | GLN719 |
3 | HOH4284 |
site_id | LC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8608 |
Chain | Residue |
3 | PHE629 |
3 | GLN718 |
3 | TRP720 |
3 | HOH4238 |
site_id | MC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS 3 8609 |
Chain | Residue |
3 | TYR405 |
site_id | MC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 3 8610 |
Chain | Residue |
3 | TRP918 |
3 | ASP919 |
3 | LEU920 |
site_id | MC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 3 8611 |
Chain | Residue |
3 | ALA268 |
3 | SER269 |
3 | ARG292 |
3 | LEU293 |
3 | ASN294 |
site_id | MC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 3 8612 |
Chain | Residue |
3 | PRO306 |
3 | ASN307 |
site_id | MC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 3 8613 |
Chain | Residue |
1 | PRO306 |
1 | ASN307 |
3 | GLY771 |
3 | HOH7227 |
site_id | MC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 4 8608 |
Chain | Residue |
1 | GLU797 |
4 | ARG282 |
site_id | MC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 4 8401 |
Chain | Residue |
4 | THR229 |
4 | VAL330 |
4 | GLY331 |
4 | ASN449 |
4 | PRO451 |
4 | HOH4011 |
site_id | MC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 8402 |
Chain | Residue |
4 | ARG557 |
4 | HIS622 |
4 | GLN628 |
4 | HOH4205 |
site_id | MC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 4 8403 |
Chain | Residue |
4 | LYS380 |
4 | ASN383 |
4 | PHE626 |
4 | TYR642 |
4 | TRP708 |
4 | HOH4214 |
site_id | NC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DMS 4 8404 |
Chain | Residue |
4 | PRO32 |
4 | PHE33 |
4 | ALA34 |
4 | TRP36 |
4 | ASP45 |
4 | ALA327 |
4 | DMS8501 |
site_id | NC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 8405 |
Chain | Residue |
4 | GLY270 |
4 | THR271 |
4 | LEU291 |
4 | ARG292 |
site_id | NC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 4 8406 |
Chain | Residue |
4 | GLU314 |
4 | HIS316 |
4 | GLY320 |
4 | THR321 |
4 | LEU322 |
site_id | NC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 4 8408 |
Chain | Residue |
4 | LEU54 |
4 | ASN55 |
4 | GLY56 |
4 | LEU125 |
4 | HOH4764 |
site_id | NC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 4 8409 |
Chain | Residue |
4 | GLU334 |
4 | VAL335 |
4 | ARG336 |
4 | HOH4209 |
4 | HOH4212 |
4 | HOH4525 |
site_id | NC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 8410 |
Chain | Residue |
4 | PRO106 |
4 | ILE107 |
4 | HOH4371 |
4 | DMS8419 |
site_id | NC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 4 8411 |
Chain | Residue |
4 | ILE576 |
4 | PRO584 |
4 | TRP585 |
4 | SER586 |
4 | ARG973 |
site_id | NC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 8412 |
Chain | Residue |
4 | VAL289 |
4 | THR290 |
4 | ARG292 |
4 | HOH4615 |
site_id | NC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8414 |
Chain | Residue |
4 | VAL84 |
4 | VAL85 |
4 | HIS93 |
site_id | OC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8416 |
Chain | Residue |
4 | LEU250 |
4 | ARG251 |
4 | ASP252 |
site_id | OC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 8417 |
Chain | Residue |
4 | PHE231 |
4 | ASN232 |
4 | ASP233 |
4 | GLU334 |
site_id | OC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8419 |
Chain | Residue |
4 | PRO106 |
4 | PRO596 |
4 | DMS8410 |
site_id | OC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8421 |
Chain | Residue |
4 | HIS93 |
4 | GLY94 |
4 | TYR95 |
site_id | OC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8423 |
Chain | Residue |
4 | TYR926 |
4 | TYR962 |
4 | ARG973 |
site_id | OC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE DMS 4 8501 |
Chain | Residue |
4 | ASP45 |
4 | HOH4512 |
4 | HOH5071 |
4 | DMS8404 |
site_id | OC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DMS 4 8503 |
Chain | Residue |
4 | PHE629 |
4 | ARG630 |
4 | GLN718 |
4 | TRP720 |
4 | HOH4238 |
site_id | OC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DMS 4 8508 |
Chain | Residue |
4 | SER923 |
4 | TYR962 |
site_id | OC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 4 8701 |
Chain | Residue |
1 | GLU136 |
1 | ILE323 |
1 | HOH5052 |
4 | GLY320 |
4 | THR321 |
4 | HOH5162 |
site_id | PC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 4 8703 |
Chain | Residue |
1 | MG3003 |
4 | GLN49 |
4 | GLN50 |
4 | ASP130 |
4 | TRP133 |
4 | HOH7255 |
site_id | PC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 4 8705 |
Chain | Residue |
4 | TRP133 |
4 | LEU134 |
4 | GLN135 |
4 | GLU136 |
4 | GLY137 |
4 | SER174 |
site_id | PC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG 4 3001 |
Chain | Residue |
4 | GLU416 |
4 | HIS418 |
4 | GLU461 |
4 | HOH4014 |
4 | HOH4078 |
4 | HOH4156 |
site_id | PC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG 4 3002 |
Chain | Residue |
4 | ASP15 |
4 | ASN18 |
4 | VAL21 |
4 | GLN163 |
4 | ASP193 |
site_id | PC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA 4 3101 |
Chain | Residue |
4 | ASP201 |
4 | PHE601 |
4 | ASN604 |
4 | HOH4278 |
4 | HOH7535 |
site_id | PC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA 4 3102 |
Chain | Residue |
4 | PHE556 |
4 | TYR559 |
4 | PRO560 |
4 | LEU562 |
4 | HOH4410 |
4 | HOH4652 |
site_id | PC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA 4 3103 |
Chain | Residue |
4 | PHE931 |
4 | PRO932 |
4 | LEU967 |
4 | MET968 |
4 | THR970 |
site_id | PC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE DMS 4 8607 |
Chain | Residue |
4 | TYR405 |
site_id | PC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DMS 4 1024 |
Chain | Residue |
2 | LYS1023 |
4 | SER647 |
4 | ASP648 |
4 | ASN649 |
4 | GLU650 |
4 | PRO703 |
4 | ASN704 |
4 | NA3104 |
site_id | QC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA 4 3104 |
Chain | Residue |
4 | SER647 |
4 | GLU650 |
4 | LEU670 |
4 | DMS1024 |
site_id | QC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG 4 3003 |
Chain | Residue |
4 | HOH4674 |
4 | HOH5175 |
4 | HOH7550 |
4 | HOH7551 |
site_id | QC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DMS 4 8610 |
Chain | Residue |
4 | ASP782 |
4 | GLN783 |
4 | PHE784 |
4 | THR785 |
4 | HIS815 |
4 | TRP842 |
site_id | QC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8611 |
Chain | Residue |
1 | ARG448 |
1 | VAL478 |
4 | ASP428 |
site_id | QC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8612 |
Chain | Residue |
4 | ARG230 |
4 | PHE231 |
4 | VAL239 |
site_id | QC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8613 |
Chain | Residue |
4 | ASP45 |
4 | ASP329 |
4 | ARG404 |
site_id | QC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8615 |
Chain | Residue |
4 | THR494 |
4 | THR496 |
4 | HOH4681 |
site_id | QC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8617 |
Chain | Residue |
2 | LYS754 |
2 | SER861 |
4 | HIS646 |
site_id | QC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE DMS 4 8618 |
Chain | Residue |
4 | GLU508 |
4 | PRO1001 |
4 | HOH4037 |
Functional Information from PROSITE/UniProt
site_id | PS00608 |
Number of Residues | 15 |
Details | GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DRNHPSVIIWSlg.NE |
Chain | Residue | Details |
1 | ASP447-GLU461 |
site_id | PS00719 |
Number of Residues | 26 |
Details | GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaVRCSHYPnhplWYtlcDryGLYVV |
Chain | Residue | Details |
1 | ASN385-VAL410 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000269|PubMed:6420154 |
Chain | Residue | Details |
1 | GLU461 | |
2 | GLU461 | |
3 | GLU461 | |
4 | GLU461 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:1350782 |
Chain | Residue | Details |
1 | GLU537 | |
2 | GLU537 | |
3 | GLU537 | |
4 | GLU537 |
site_id | SWS_FT_FI3 |
Number of Residues | 28 |
Details | BINDING: |
Chain | Residue | Details |
1 | ASN102 | |
2 | GLU461 | |
2 | GLU537 | |
2 | PHE601 | |
2 | ASN604 | |
2 | TRP999 | |
3 | ASN102 | |
3 | ASP201 | |
3 | GLU461 | |
3 | GLU537 | |
3 | PHE601 | |
1 | ASP201 | |
3 | ASN604 | |
3 | TRP999 | |
4 | ASN102 | |
4 | ASP201 | |
4 | GLU461 | |
4 | GLU537 | |
4 | PHE601 | |
4 | ASN604 | |
4 | TRP999 | |
1 | GLU461 | |
1 | GLU537 | |
1 | PHE601 | |
1 | ASN604 | |
1 | TRP999 | |
2 | ASN102 | |
2 | ASP201 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11045615 |
Chain | Residue | Details |
1 | GLU416 | |
4 | GLU416 | |
4 | HIS418 | |
4 | ASN597 | |
1 | HIS418 | |
1 | ASN597 | |
2 | GLU416 | |
2 | HIS418 | |
2 | ASN597 | |
3 | GLU416 | |
3 | HIS418 | |
3 | ASN597 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | SITE: Transition state stabilizer |
Chain | Residue | Details |
1 | HIS357 | |
1 | HIS391 | |
2 | HIS357 | |
2 | HIS391 | |
3 | HIS357 | |
3 | HIS391 | |
4 | HIS357 | |
4 | HIS391 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | SITE: Important for ensuring that an appropriate proportion of lactose is converted to allolactose |
Chain | Residue | Details |
1 | TRP999 | |
2 | TRP999 | |
3 | TRP999 | |
4 | TRP999 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
1 | ASP201 | |
1 | ASN604 | |
1 | HIS357 | |
1 | HIS391 | |
1 | GLU416 | |
1 | HIS418 | |
1 | GLU461 | |
1 | GLU537 | |
1 | ASN597 | |
1 | PHE601 |
site_id | MCSA2 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
2 | ASP201 | |
2 | ASN604 | |
2 | HIS357 | |
2 | HIS391 | |
2 | GLU416 | |
2 | HIS418 | |
2 | GLU461 | |
2 | GLU537 | |
2 | ASN597 | |
2 | PHE601 |
site_id | MCSA3 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
3 | ASP201 | |
3 | ASN604 | |
3 | HIS357 | |
3 | HIS391 | |
3 | GLU416 | |
3 | HIS418 | |
3 | GLU461 | |
3 | GLU537 | |
3 | ASN597 | |
3 | PHE601 |
site_id | MCSA4 |
Number of Residues | 10 |
Details | M-CSA 422 |
Chain | Residue | Details |
4 | ASP201 | |
4 | ASN604 | |
4 | HIS357 | |
4 | HIS391 | |
4 | GLU416 | |
4 | HIS418 | |
4 | GLU461 | |
4 | GLU537 | |
4 | ASN597 | |
4 | PHE601 |