Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3MUY

E. coli (lacZ) beta-galactosidase (R599A)

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000287	molecular_function	magnesium ion binding
1	0003824	molecular_function	catalytic activity
1	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
1	0004565	molecular_function	beta-galactosidase activity
1	0005975	biological_process	carbohydrate metabolic process
1	0005990	biological_process	lactose catabolic process
1	0009341	cellular_component	beta-galactosidase complex
1	0016787	molecular_function	hydrolase activity
1	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
1	0030246	molecular_function	carbohydrate binding
1	0031420	molecular_function	alkali metal ion binding
1	0042802	molecular_function	identical protein binding
1	0046872	molecular_function	metal ion binding
2	0000287	molecular_function	magnesium ion binding
2	0003824	molecular_function	catalytic activity
2	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
2	0004565	molecular_function	beta-galactosidase activity
2	0005975	biological_process	carbohydrate metabolic process
2	0005990	biological_process	lactose catabolic process
2	0009341	cellular_component	beta-galactosidase complex
2	0016787	molecular_function	hydrolase activity
2	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
2	0030246	molecular_function	carbohydrate binding
2	0031420	molecular_function	alkali metal ion binding
2	0042802	molecular_function	identical protein binding
2	0046872	molecular_function	metal ion binding
3	0000287	molecular_function	magnesium ion binding
3	0003824	molecular_function	catalytic activity
3	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
3	0004565	molecular_function	beta-galactosidase activity
3	0005975	biological_process	carbohydrate metabolic process
3	0005990	biological_process	lactose catabolic process
3	0009341	cellular_component	beta-galactosidase complex
3	0016787	molecular_function	hydrolase activity
3	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
3	0030246	molecular_function	carbohydrate binding
3	0031420	molecular_function	alkali metal ion binding
3	0042802	molecular_function	identical protein binding
3	0046872	molecular_function	metal ion binding
4	0000287	molecular_function	magnesium ion binding
4	0003824	molecular_function	catalytic activity
4	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
4	0004565	molecular_function	beta-galactosidase activity
4	0005975	biological_process	carbohydrate metabolic process
4	0005990	biological_process	lactose catabolic process
4	0009341	cellular_component	beta-galactosidase complex
4	0016787	molecular_function	hydrolase activity
4	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
4	0030246	molecular_function	carbohydrate binding
4	0031420	molecular_function	alkali metal ion binding
4	0042802	molecular_function	identical protein binding
4	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS 1 8401

Chain	Residue
1	THR229
1	VAL330
1	GLY331
1	ASN449
1	PRO451
1	ARG482
1	HOH4011

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 8402

Chain	Residue
1	GLN628
1	HOH4205
1	ARG557
1	HIS622

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 1 8403

Chain	Residue
1	LYS380
1	ASN383
1	PHE626
1	TYR642
1	TRP708
1	HOH4214

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 1 8404

Chain	Residue
1	PRO32
1	PHE33
1	TRP36
1	ASP45
1	ALA327
1	DMS8501

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 8405

Chain	Residue
1	THR271
1	LEU291
1	ARG292
1	HOH4724

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 8406

Chain	Residue
1	HIS316
1	GLY320
1	LEU322
1	MG3003

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 8407

Chain	Residue
1	ARG505
1	GLU508
1	PRO1001
1	HOH4037

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 1 8408

Chain	Residue
1	LEU54
1	ASN55

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 1 8409

Chain	Residue
1	GLU334
1	VAL335
1	ARG336
1	PRO480
1	HOH4525

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 1 8411

Chain	Residue
1	ILE576
1	PRO584
1	TRP585
1	SER586
1	ARG973

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 1 8412

Chain	Residue
1	GLY275
1	GLU277
1	VAL289
1	THR290
1	ARG292

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 8414

Chain	Residue
1	THR83
1	VAL85
1	HIS93

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 8416

Chain	Residue
1	ARG251
1	ASP252
4	ARG251

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMS 1 8419

Chain	Residue
1	PRO596

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 8421

Chain	Residue
1	HIS93
1	GLY94
1	TYR95

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS 1 8425

Chain	Residue
1	SER647
1	ASP648
1	ASN649
1	GLU650
1	PRO703
1	ASN704
1	NA3103
3	LYS1023

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 1 8501

Chain	Residue
1	HOH4318
1	DMS8404

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 8503

Chain	Residue
1	PHE629
1	GLN718
1	TRP720

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 8504

Chain	Residue
1	SER132
1	TRP133
1	GLU136
1	HIS216

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 1 8602

Chain	Residue
1	GLN266
1	VAL267

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 1 3001

Chain	Residue
1	GLU416
1	HIS418
1	GLU461
1	HOH4014
1	HOH4078
1	HOH4156

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG 1 3002

Chain	Residue
1	ASP15
1	ASN18
1	VAL21
1	GLN163
1	ASP193

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 1 3003

Chain	Residue
1	HOH4674
1	HOH5163
1	HOH5173
1	HOH7562
1	DMS8406
4	DMS8703

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 1 3101

Chain	Residue
1	PHE601
1	ASN604
1	HOH4278
1	HOH7547
1	HOH7560
1	ASP201

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 1 3102

Chain	Residue
1	PHE556
1	TYR559
1	PRO560
1	LEU562
1	HOH4410
1	HOH4652

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA 1 3103

Chain	Residue
1	SER647
1	GLU650
1	LEU670
1	DMS8425

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 1 8603

Chain	Residue
1	ARG404
1	TYR405

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMS 1 8604

Chain	Residue
1	GLU744

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 8605

Chain	Residue
1	GLY248
1	GLU249
1	LEU250
1	ARG251

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 1 8606

Chain	Residue
1	ASN38
1	SER39
1	LEU322
1	HOH4691
4	GLN49

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 1 8607

Chain	Residue
1	TYR472
1	THR494
1	THR496

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 1 8609

Chain	Residue
1	GLU57
1	TRP58
1	ARG59
1	THR126

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS 2 8401

Chain	Residue
2	THR229
2	VAL330
2	GLY331
2	ASN449
2	PRO451
2	ARG482
2	HOH4011

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 8402

Chain	Residue
2	ARG557
2	HIS622
2	GLN623
2	GLN628

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 2 8403

Chain	Residue
2	LYS380
2	ASN383
2	PHE626
2	TYR642
2	TRP708
2	HOH4214

site_id	DC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DMS 2 8404

Chain	Residue
2	PRO32
2	PHE33
2	ALA34
2	TRP36
2	ASP45
2	ARG310
2	ALA327
2	HOH4423
2	DMS8606

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 8405

Chain	Residue
2	GLY270
2	THR271
2	LEU291
2	ARG292
2	HOH4724

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 8406

Chain	Residue
2	GLU314
2	HIS316
2	GLY320
2	THR321
2	LEU322

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 8408

Chain	Residue
2	SER53
2	LEU54
2	ASN55
2	LEU125

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 2 8409

Chain	Residue
2	GLU334
2	VAL335
2	ARG336
2	PRO480
2	HOH4209
2	HOH4212

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 8410

Chain	Residue
2	PRO106
2	HOH4371
2	DMS8605

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 8411

Chain	Residue
2	ILE576
2	PRO584
2	TRP585
2	SER586
2	ARG973

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 8412

Chain	Residue
2	GLY275
2	VAL289
2	THR290
2	ARG292

site_id	EC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 8414

Chain	Residue
2	VAL84
2	VAL85
2	HIS93

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 8416

Chain	Residue
2	LEU250
2	ARG251
2	ASP252

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 8417

Chain	Residue
2	PHE231
2	ASN232
2	GLU334
2	ARG336

site_id	FC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 8420

Chain	Residue
2	ASP428
3	ARG448
3	VAL478

site_id	FC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 8421

Chain	Residue
2	HIS93
2	GLY94
2	TYR95

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 8423

Chain	Residue
2	TYR926
2	TYR962
2	ARG973

site_id	FC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 8425

Chain	Residue
2	ASP648
2	ASN649
2	GLU650
2	ASN704
2	NA3102

site_id	FC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 8502

Chain	Residue
2	GLU57
2	LEU125
2	THR126
2	HOH4539

site_id	FC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 8504

Chain	Residue
2	ARG37
2	GLN50
2	SER132
2	TRP133
2	HIS216

site_id	FC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 8508

Chain	Residue
2	SER923
2	TYR926
2	TYR962

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 8601

Chain	Residue
2	VAL267
2	ASN294
2	VAL295
2	GLU296

site_id	GC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 2 3001

Chain	Residue
2	GLU416
2	HIS418
2	GLU461
2	HOH4014
2	HOH4078
2	HOH4156

site_id	GC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG 2 3002

Chain	Residue
2	ASP15
2	ASN18
2	VAL21
2	GLN163
2	ASP193

site_id	GC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 2 3101

Chain	Residue
2	PHE556
2	TYR559
2	PRO560
2	LEU562
2	HOH4410
2	HOH4652

site_id	GC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA 2 3102

Chain	Residue
2	SER647
2	GLU650
2	LEU670
2	DMS8425

site_id	GC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA 2 3103

Chain	Residue
2	PHE931
2	PRO932
2	LEU967
2	THR970
2	HOH4207

site_id	GC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA 2 3104

Chain	Residue
2	ASP201
2	PHE601
2	ASN604
2	HOH4278
2	HOH7560

site_id	GC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 8602

Chain	Residue
2	PHE231
2	ASN232
2	ARG237
2	ALA238

site_id	GC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 8603

Chain	Residue
2	ASN102
2	ASP598
2	PHE601
2	VAL795

site_id	GC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 2 8604

Chain	Residue
2	ARG404
2	TYR405

site_id	HC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 8605

Chain	Residue
2	TYR105
2	PRO106
2	PRO596
2	HOH4481
2	DMS8410

site_id	HC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 8606

Chain	Residue
2	ASP45
2	ARG46
2	PRO47
2	DMS8404

site_id	HC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 2 8607

Chain	Residue
2	PRO306
2	ASN307

site_id	HC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 2 8608

Chain	Residue
2	LEU250
3	ARG425

site_id	HC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 2 8609

Chain	Residue
2	SER963
2	GLN965
2	GLU969
2	HIS977
2	GLU979
2	HOH4310

site_id	HC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 8610

Chain	Residue
2	TYR472
2	THR494
2	THR496
2	ASP497
2	HOH4681

site_id	HC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 2 8611

Chain	Residue
2	GLN783
2	PHE784
2	THR785
2	HIS815
2	TRP842

site_id	HC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 2 8612

Chain	Residue
2	PHE989
2	ARG1013
2	TYR1014
2	HIS1015

site_id	HC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 2 8613

Chain	Residue
1	LEU740
1	THR742
2	GLN266

site_id	IC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 3 8401

Chain	Residue
3	THR229
3	GLY331
3	ASN449
3	PRO451
3	ARG482
3	HOH4011

site_id	IC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8402

Chain	Residue
3	ARG557
3	HIS622
3	GLN623
3	GLN628

site_id	IC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 3 8403

Chain	Residue
3	LYS380
3	ASN383
3	PHE626
3	TYR642
3	TRP708
3	HOH4214

site_id	IC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS 3 8404

Chain	Residue
3	PRO32
3	PHE33
3	TRP36
3	ASP45
3	ALA327
3	HOH4423
3	DMS8501

site_id	IC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 8405

Chain	Residue
3	GLY270
3	THR271
3	LEU291
3	ARG292
3	HOH4724

site_id	IC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 8407

Chain	Residue
3	ARG505
3	GLU508
3	PRO1001

site_id	IC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8408

Chain	Residue
3	SER53
3	LEU54
3	ASN55
3	HOH4764

site_id	IC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8409

Chain	Residue
3	GLU334
3	VAL335
3	ARG336
3	HOH4212

site_id	IC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 8410

Chain	Residue
3	PRO106
3	HOH4371
3	DMS8605

site_id	JC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 8411

Chain	Residue
3	ILE576
3	PRO584
3	TRP585
3	SER586
3	ARG973

site_id	JC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8412

Chain	Residue
3	GLY275
3	VAL289
3	THR290
3	ARG292

site_id	JC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 8414

Chain	Residue
3	VAL84
3	VAL85
3	HIS93

site_id	JC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 8415

Chain	Residue
3	LYS621
3	TRP717
3	HOH4339

site_id	JC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 8416

Chain	Residue
3	LEU250
3	ARG251
3	ASP252

site_id	JC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8417

Chain	Residue
3	PHE231
3	ASN232
3	ASP233
3	GLU334

site_id	JC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 3 8420

Chain	Residue
2	VAL478
3	ASP428

site_id	JC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 8421

Chain	Residue
3	HIS93
3	GLY94
3	TYR95

site_id	JC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 3 8423

Chain	Residue
3	TYR926
3	ARG973

site_id	KC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8425

Chain	Residue
3	ASP648
3	GLU650
3	ASN704
3	NA3104

site_id	KC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 3 8428

Chain	Residue
3	ASN102
3	DMS8602

site_id	KC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 8501

Chain	Residue
3	HOH4318
3	HOH4512
3	DMS8404

site_id	KC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8601

Chain	Residue
3	VAL267
3	ASN294
3	VAL295
3	GLU296

site_id	KC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 3 3001

Chain	Residue
3	GLU416
3	HIS418
3	GLU461
3	HOH4014
3	HOH4078
3	HOH4156

site_id	KC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG 3 3002

Chain	Residue
3	ASP15
3	ASN18
3	VAL21
3	GLN163
3	ASP193

site_id	KC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA 3 3101

Chain	Residue
3	ASP201
3	PHE601
3	ASN604
3	HOH4278
3	HOH7575

site_id	KC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 3 3102

Chain	Residue
3	PHE556
3	TYR559
3	PRO560
3	LEU562
3	HOH4410
3	HOH4652

site_id	KC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 3 3103

Chain	Residue
3	PHE931
3	PRO932
3	LEU967
3	MET968
3	THR970
3	HOH4207

site_id	LC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA 3 3104

Chain	Residue
3	SER647
3	GLU650
3	LEU670
3	HOH5010
3	DMS8425

site_id	LC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA 3 3105

Chain	Residue
3	HOH4476
3	HOH5106
3	HOH7509

site_id	LC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 8602

Chain	Residue
3	ASN102
3	ASP598
3	PHE601
3	VAL795
3	DMS8428

site_id	LC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 3 8603

Chain	Residue
3	GLN266
3	VAL267
3	ALA268
3	SER269
4	LEU740
4	THR742

site_id	LC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8604

Chain	Residue
3	ALA61
3	TRP62
3	GLU80
3	ASP82

site_id	LC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 3 8605

Chain	Residue
3	PRO106
3	DMS8410

site_id	LC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8606

Chain	Residue
3	TYR472
3	THR494
3	THR496
3	ASP497

site_id	LC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 8607

Chain	Residue
3	TRP695
3	GLN719
3	HOH4284

site_id	LC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8608

Chain	Residue
3	PHE629
3	GLN718
3	TRP720
3	HOH4238

site_id	MC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMS 3 8609

Chain	Residue
3	TYR405

site_id	MC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 3 8610

Chain	Residue
3	TRP918
3	ASP919
3	LEU920

site_id	MC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 3 8611

Chain	Residue
3	ALA268
3	SER269
3	ARG292
3	LEU293
3	ASN294

site_id	MC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 3 8612

Chain	Residue
3	PRO306
3	ASN307

site_id	MC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 3 8613

Chain	Residue
1	PRO306
1	ASN307
3	GLY771
3	HOH7227

site_id	MC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 4 8608

Chain	Residue
1	GLU797
4	ARG282

site_id	MC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 4 8401

Chain	Residue
4	THR229
4	VAL330
4	GLY331
4	ASN449
4	PRO451
4	HOH4011

site_id	MC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 8402

Chain	Residue
4	ARG557
4	HIS622
4	GLN628
4	HOH4205

site_id	MC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 4 8403

Chain	Residue
4	LYS380
4	ASN383
4	PHE626
4	TYR642
4	TRP708
4	HOH4214

site_id	NC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS 4 8404

Chain	Residue
4	PRO32
4	PHE33
4	ALA34
4	TRP36
4	ASP45
4	ALA327
4	DMS8501

site_id	NC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 8405

Chain	Residue
4	GLY270
4	THR271
4	LEU291
4	ARG292

site_id	NC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 4 8406

Chain	Residue
4	GLU314
4	HIS316
4	GLY320
4	THR321
4	LEU322

site_id	NC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 4 8408

Chain	Residue
4	LEU54
4	ASN55
4	GLY56
4	LEU125
4	HOH4764

site_id	NC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 4 8409

Chain	Residue
4	GLU334
4	VAL335
4	ARG336
4	HOH4209
4	HOH4212
4	HOH4525

site_id	NC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 8410

Chain	Residue
4	PRO106
4	ILE107
4	HOH4371
4	DMS8419

site_id	NC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 4 8411

Chain	Residue
4	ILE576
4	PRO584
4	TRP585
4	SER586
4	ARG973

site_id	NC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 8412

Chain	Residue
4	VAL289
4	THR290
4	ARG292
4	HOH4615

site_id	NC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8414

Chain	Residue
4	VAL84
4	VAL85
4	HIS93

site_id	OC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8416

Chain	Residue
4	LEU250
4	ARG251
4	ASP252

site_id	OC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 8417

Chain	Residue
4	PHE231
4	ASN232
4	ASP233
4	GLU334

site_id	OC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8419

Chain	Residue
4	PRO106
4	PRO596
4	DMS8410

site_id	OC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8421

Chain	Residue
4	HIS93
4	GLY94
4	TYR95

site_id	OC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8423

Chain	Residue
4	TYR926
4	TYR962
4	ARG973

site_id	OC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS 4 8501

Chain	Residue
4	ASP45
4	HOH4512
4	HOH5071
4	DMS8404

site_id	OC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS 4 8503

Chain	Residue
4	PHE629
4	ARG630
4	GLN718
4	TRP720
4	HOH4238

site_id	OC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS 4 8508

Chain	Residue
4	SER923
4	TYR962

site_id	OC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 4 8701

Chain	Residue
1	GLU136
1	ILE323
1	HOH5052
4	GLY320
4	THR321
4	HOH5162

site_id	PC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 4 8703

Chain	Residue
1	MG3003
4	GLN49
4	GLN50
4	ASP130
4	TRP133
4	HOH7255

site_id	PC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 4 8705

Chain	Residue
4	TRP133
4	LEU134
4	GLN135
4	GLU136
4	GLY137
4	SER174

site_id	PC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG 4 3001

Chain	Residue
4	GLU416
4	HIS418
4	GLU461
4	HOH4014
4	HOH4078
4	HOH4156

site_id	PC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG 4 3002

Chain	Residue
4	ASP15
4	ASN18
4	VAL21
4	GLN163
4	ASP193

site_id	PC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA 4 3101

Chain	Residue
4	ASP201
4	PHE601
4	ASN604
4	HOH4278
4	HOH7535

site_id	PC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA 4 3102

Chain	Residue
4	PHE556
4	TYR559
4	PRO560
4	LEU562
4	HOH4410
4	HOH4652

site_id	PC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA 4 3103

Chain	Residue
4	PHE931
4	PRO932
4	LEU967
4	MET968
4	THR970

site_id	PC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMS 4 8607

Chain	Residue
4	TYR405

site_id	PC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS 4 1024

Chain	Residue
2	LYS1023
4	SER647
4	ASP648
4	ASN649
4	GLU650
4	PRO703
4	ASN704
4	NA3104

site_id	QC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA 4 3104

Chain	Residue
4	SER647
4	GLU650
4	LEU670
4	DMS1024

site_id	QC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG 4 3003

Chain	Residue
4	HOH4674
4	HOH5175
4	HOH7550
4	HOH7551

site_id	QC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS 4 8610

Chain	Residue
4	ASP782
4	GLN783
4	PHE784
4	THR785
4	HIS815
4	TRP842

site_id	QC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8611

Chain	Residue
1	ARG448
1	VAL478
4	ASP428

site_id	QC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8612

Chain	Residue
4	ARG230
4	PHE231
4	VAL239

site_id	QC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8613

Chain	Residue
4	ASP45
4	ASP329
4	ARG404

site_id	QC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8615

Chain	Residue
4	THR494
4	THR496
4	HOH4681

site_id	QC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8617

Chain	Residue
2	LYS754
2	SER861
4	HIS646

site_id	QC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS 4 8618

Chain	Residue
4	GLU508
4	PRO1001
4	HOH4037

Functional Information from PROSITE/UniProt

site_id	PS00608
Number of Residues	15
Details	GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DRNHPSVIIWSlg.NE

Chain	Residue	Details
1	ASP447-GLU461

site_id	PS00719
Number of Residues	26
Details	GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaVRCSHYPnhplWYtlcDryGLYVV

Chain	Residue	Details
1	ASN385-VAL410

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"6420154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"1350782","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11045615","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Important for ensuring that an appropriate proportion of lactose is converted to allolactose"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	10
Details	M-CSA 422

Chain

Residue

Details

site_id	MCSA2
Number of Residues	10
Details	M-CSA 422

Chain

Residue

Details

site_id	MCSA3
Number of Residues	10
Details	M-CSA 422

Chain

Residue

Details

site_id	MCSA4
Number of Residues	10
Details	M-CSA 422

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)