3MSH

Crystal structure of Hepatitis B X-Interacting Protein at high resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005765	cellular_component	lysosomal membrane
A	0005829	cellular_component	cytosol
A	0008361	biological_process	regulation of cell size
A	0009615	biological_process	response to virus
A	0010628	biological_process	positive regulation of gene expression
A	0019079	biological_process	viral genome replication
A	0031902	cellular_component	late endosome membrane
A	0032008	biological_process	positive regulation of TOR signaling
A	0032757	biological_process	positive regulation of interleukin-8 production
A	0032991	cellular_component	protein-containing complex
A	0038202	biological_process	TORC1 signaling
A	0043066	biological_process	negative regulation of apoptotic process
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0060090	molecular_function	molecular adaptor activity
A	0061462	biological_process	protein localization to lysosome
A	0071230	biological_process	cellular response to amino acid stimulus
A	0071986	cellular_component	Ragulator complex
A	1900182	biological_process	positive regulation of protein localization to nucleus
A	1904263	biological_process	positive regulation of TORC1 signaling
A	1905636	biological_process	positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
A	1990877	cellular_component	FNIP-folliculin RagC/D GAP

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 998

Chain	Residue
A	HIS8
A	ASP11
A	MET13
A	PRO16
A	ILE18
A	PG4106
A	HOH155

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IPA A 100

Chain	Residue
A	CYS33
A	ARG34
A	HOH153
A	HOH166
A	GLU6
A	GLY32

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IPA A 101

Chain	Residue
A	GLU68
A	ASP70

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site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE IPA A 104

Chain	Residue
A	LEU55
A	THR56
A	LEU67
A	GLU68
A	SER69
A	ASN71
A	GLY72
A	HIS87

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 105

Chain	Residue
A	THR36
A	LEU55
A	ASN71
A	HIS87

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site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PG4 A 106

Chain	Residue
A	HIS8
A	ASP11
A	THR12
A	ASP25
A	LEU29
A	HIS79
A	ASP80
A	ILE82
A	HOH102
A	HOH142
A	HOH165
A	GOL998

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	MET1

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