3MS5

Crystal Structure of Human gamma-butyrobetaine,2-oxoglutarate dioxygenase 1 (BBOX1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0008336	molecular_function	gamma-butyrobetaine dioxygenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0042802	molecular_function	identical protein binding
A	0045329	biological_process	carnitine biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI A 388

Chain	Residue
A	HIS202
A	ASP204
A	HIS347
A	OGA390
A	HOH800

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 389

Chain	Residue
A	CYS38
A	CYS40
A	CYS43
A	HIS82

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE OGA A 390

Chain	Residue
A	VAL183
A	ALA193
A	LEU199
A	HIS202
A	ASP204
A	HIS347
A	ARG349
A	ARG360
A	LEU362
A	NI388
A	REE391
A	EDO393
A	EDO395
A	HOH800

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE REE A 391

Chain	Residue
A	TYR177
A	TRP181
A	ASN191
A	TYR194
A	ASP204
A	TYR205
A	ASN292
A	TYR366
A	OGA390
A	EDO393
A	HOH418
A	HOH485

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 392

Chain	Residue
A	HIS209
A	GLU279
A	TRP343
A	HOH744

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 393

Chain	Residue
A	ASN191
A	ALA193
A	LEU199
A	HIS202
A	ASN292
A	OGA390
A	REE391
A	HOH457

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 394

Chain	Residue
A	LEU54
A	LYS198
A	LEU199
A	SER200
A	ASN292
A	ASN293
A	ALA294
A	HOH486
A	HOH597
A	HOH637

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 395

Chain	Residue
A	LEU217
A	SER229
A	HIS347
A	GLY348
A	OGA390

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 396

Chain	Residue
A	TYR173
A	TYR173
A	LEU174
A	LEU174
A	HOH556
A	HOH556
A	HOH590
A	HOH590

---

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 397

Chain	Residue
A	TYR44
A	LYS49
A	ALA50
A	THR260
A	ALA294
A	ARG296
A	THR298
A	HOH421
A	HOH528
A	HOH799

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 398

Chain	Residue
A	LYS145
A	ASP341
A	TRP369
A	HOH517
A	HOH733

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 399

Chain	Residue
A	GLN239
A	GLY284
A	GLN285
A	VAL286

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 400

Chain	Residue
A	TRP33
A	ARG94
A	PHE96
A	ARG101
A	THR298
A	ILE299
A	PHE300
A	HOH680

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9QZU7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---