3MR1
Crystal structure of methionine aminopeptidase from Rickettsia prowazekii
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0004239 | molecular_function | initiator methionyl aminopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008235 | molecular_function | metalloexopeptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0004239 | molecular_function | initiator methionyl aminopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008235 | molecular_function | metalloexopeptidase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0004239 | molecular_function | initiator methionyl aminopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008235 | molecular_function | metalloexopeptidase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0004239 | molecular_function | initiator methionyl aminopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008235 | molecular_function | metalloexopeptidase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 249 |
| Chain | Residue |
| A | ASP105 |
| A | HIS168 |
| A | GLU201 |
| A | GLU233 |
| A | MN250 |
| A | PO4252 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 250 |
| Chain | Residue |
| A | MN249 |
| A | PO4252 |
| A | HOH728 |
| A | ASP94 |
| A | ASP105 |
| A | GLU233 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 251 |
| Chain | Residue |
| A | ASN72 |
| A | VAL74 |
| A | SER229 |
| A | HOH726 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PO4 A 252 |
| Chain | Residue |
| A | HIS77 |
| A | ASP94 |
| A | ASP105 |
| A | HIS168 |
| A | HIS175 |
| A | GLU201 |
| A | GLU233 |
| A | MN249 |
| A | MN250 |
| A | HOH728 |
| A | HOH742 |
| A | HOH744 |
| A | HOH760 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 249 |
| Chain | Residue |
| B | ASP105 |
| B | HIS168 |
| B | GLU201 |
| B | GLU233 |
| B | MN250 |
| B | PO4252 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 250 |
| Chain | Residue |
| B | ASP94 |
| B | ASP105 |
| B | GLU233 |
| B | MN249 |
| B | PO4252 |
| B | HOH786 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 251 |
| Chain | Residue |
| B | ASN72 |
| B | VAL74 |
| B | SER229 |
| B | HOH309 |
| B | HOH450 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PO4 B 252 |
| Chain | Residue |
| B | HIS77 |
| B | ASP94 |
| B | ASP105 |
| B | HIS168 |
| B | HIS175 |
| B | GLU201 |
| B | GLU233 |
| B | MN249 |
| B | MN250 |
| B | HOH785 |
| B | HOH786 |
| B | HOH787 |
| B | HOH788 |
| B | HOH799 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 249 |
| Chain | Residue |
| C | ASP105 |
| C | HIS168 |
| C | GLU201 |
| C | GLU233 |
| C | MN250 |
| C | PO4252 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN C 250 |
| Chain | Residue |
| C | ASP94 |
| C | ASP105 |
| C | GLU233 |
| C | MN249 |
| C | PO4252 |
| C | HOH712 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 251 |
| Chain | Residue |
| C | ASN72 |
| C | VAL74 |
| C | SER229 |
| C | HOH266 |
| C | HOH277 |
| site_id | BC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 C 252 |
| Chain | Residue |
| C | HIS77 |
| C | ASP94 |
| C | ASP105 |
| C | HIS168 |
| C | HIS175 |
| C | GLU201 |
| C | GLU233 |
| C | MN249 |
| C | MN250 |
| C | HOH626 |
| C | HOH712 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN D 249 |
| Chain | Residue |
| D | ASP105 |
| D | HIS168 |
| D | GLU201 |
| D | GLU233 |
| D | MN250 |
| D | PO4252 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN D 250 |
| Chain | Residue |
| D | HOH929 |
| D | ASP94 |
| D | ASP105 |
| D | GLU233 |
| D | MN249 |
| D | PO4252 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA D 251 |
| Chain | Residue |
| D | ASN72 |
| D | VAL74 |
| D | SER229 |
| D | HOH280 |
| site_id | BC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 D 252 |
| Chain | Residue |
| D | HIS77 |
| D | ASP94 |
| D | ASP105 |
| D | HIS168 |
| D | PHE174 |
| D | HIS175 |
| D | GLU201 |
| D | GLU233 |
| D | MN249 |
| D | MN250 |
| D | HOH929 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 253 |
| Chain | Residue |
| D | TYR60 |
| D | PHE174 |
| D | HIS175 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 254 |
| Chain | Residue |
| D | LYS3 |
| D | HIS5 |
| D | ARG172 |
Functional Information from PROSITE/UniProt
| site_id | PS00680 |
| Number of Residues | 19 |
| Details | MAP_1 Methionine aminopeptidase subfamily 1 signature. YtGHGIGrvfHdkpsIl.NY |
| Chain | Residue | Details |
| A | TYR165-TYR183 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01974 |
| Chain | Residue | Details |
| A | HIS77 | |
| B | HIS77 | |
| C | HIS77 | |
| D | HIS77 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|Ref.2, ECO:0000269|Ref.3 |
| Chain | Residue | Details |
| A | ASP94 | |
| B | GLU233 | |
| C | ASP94 | |
| C | ASP105 | |
| C | HIS168 | |
| C | GLU201 | |
| C | GLU233 | |
| D | ASP94 | |
| D | ASP105 | |
| D | HIS168 | |
| D | GLU201 | |
| A | ASP105 | |
| D | GLU233 | |
| A | HIS168 | |
| A | GLU201 | |
| A | GLU233 | |
| B | ASP94 | |
| B | ASP105 | |
| B | HIS168 | |
| B | GLU201 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01974, ECO:0000269|Ref.3 |
| Chain | Residue | Details |
| A | HIS175 | |
| B | HIS175 | |
| C | HIS175 | |
| D | HIS175 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|Ref.3 |
| Chain | Residue | Details |
| A | TRP219 | |
| B | TRP219 | |
| C | TRP219 | |
| D | TRP219 |
