Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3MMY

Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000922	cellular_component	spindle pole
A	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
A	0001650	cellular_component	fibrillar center
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005643	cellular_component	nuclear pore
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0006405	biological_process	RNA export from nucleus
A	0006406	biological_process	mRNA export from nucleus
A	0006913	biological_process	nucleocytoplasmic transport
A	0008017	molecular_function	microtubule binding
A	0043130	molecular_function	ubiquitin binding
A	0051301	biological_process	cell division
A	0060236	biological_process	regulation of mitotic spindle organization
A	0071407	biological_process	cellular response to organic cyclic compound
A	0097431	cellular_component	mitotic spindle pole
B	0005643	cellular_component	nuclear pore
C	0000922	cellular_component	spindle pole
C	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
C	0001650	cellular_component	fibrillar center
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005643	cellular_component	nuclear pore
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0006405	biological_process	RNA export from nucleus
C	0006406	biological_process	mRNA export from nucleus
C	0006913	biological_process	nucleocytoplasmic transport
C	0008017	molecular_function	microtubule binding
C	0043130	molecular_function	ubiquitin binding
C	0051301	biological_process	cell division
C	0060236	biological_process	regulation of mitotic spindle organization
C	0071407	biological_process	cellular response to organic cyclic compound
C	0097431	cellular_component	mitotic spindle pole
D	0005643	cellular_component	nuclear pore
E	0000922	cellular_component	spindle pole
E	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
E	0001650	cellular_component	fibrillar center
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005643	cellular_component	nuclear pore
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0006405	biological_process	RNA export from nucleus
E	0006406	biological_process	mRNA export from nucleus
E	0006913	biological_process	nucleocytoplasmic transport
E	0008017	molecular_function	microtubule binding
E	0043130	molecular_function	ubiquitin binding
E	0051301	biological_process	cell division
E	0060236	biological_process	regulation of mitotic spindle organization
E	0071407	biological_process	cellular response to organic cyclic compound
E	0097431	cellular_component	mitotic spindle pole
F	0005643	cellular_component	nuclear pore
G	0000922	cellular_component	spindle pole
G	0000972	biological_process	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
G	0001650	cellular_component	fibrillar center
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005635	cellular_component	nuclear envelope
G	0005643	cellular_component	nuclear pore
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0006405	biological_process	RNA export from nucleus
G	0006406	biological_process	mRNA export from nucleus
G	0006913	biological_process	nucleocytoplasmic transport
G	0008017	molecular_function	microtubule binding
G	0043130	molecular_function	ubiquitin binding
G	0051301	biological_process	cell division
G	0060236	biological_process	regulation of mitotic spindle organization
G	0071407	biological_process	cellular response to organic cyclic compound
G	0097431	cellular_component	mitotic spindle pole
H	0005643	cellular_component	nuclear pore

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MES A 1001

Chain	Residue
A	ASP96
A	ASP97
A	LYS100
A	TRP135
A	SER142
E	LYS224

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES C 1001

Chain	Residue
C	LYS100
C	MET112
C	TRP135
C	THR158
C	SER95
C	ASP96
C	ASP97

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES E 1001

Chain	Residue
E	ASP96
E	ASP97
E	LYS100
E	TRP135
E	LYS137
E	SER142
E	HOH2168

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MES G 1001

Chain	Residue
G	SER95
G	ASP96
G	ASP97
G	SER99
G	LYS100
G	MET112
G	TRP135
G	THR158

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VFTAscDkTAKMWDL

Chain	Residue	Details
A	VAL101-LEU115
A	VAL144-THR158

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	THR229
C	THR229
E	THR229
G	THR229

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)