3MLM
Crystal structure of Bn IV in complex with myristic acid: A Lys49 myotoxic phospholipase A2 from Bothrops neuwiedi venom
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | phospholipase A2 activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| A | 0050482 | biological_process | arachidonic acid secretion |
| A | 0090729 | molecular_function | toxin activity |
| B | 0004623 | molecular_function | phospholipase A2 activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006644 | biological_process | phospholipid metabolic process |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0042130 | biological_process | negative regulation of T cell proliferation |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| B | 0050482 | biological_process | arachidonic acid secretion |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 123 |
| Chain | Residue |
| A | LYS19 |
| A | THR55 |
| A | LYS105 |
| A | ARG108 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 122 |
| Chain | Residue |
| A | GLY32 |
| A | ARG33 |
| A | LYS52 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MYR A 124 |
| Chain | Residue |
| A | ILE9 |
| A | PRO17 |
| A | TYR21 |
| A | GLY29 |
| A | HOH162 |
| A | LEU5 |
| A | GLY6 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 123 |
| Chain | Residue |
| B | LYS19 |
| B | LYS105 |
| B | ARG108 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 122 |
| Chain | Residue |
| B | GLY32 |
| B | ARG33 |
| B | LYS52 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MYR B 125 |
| Chain | Residue |
| B | LEU5 |
| B | GLY6 |
| B | PRO17 |
| B | TYR21 |
| B | ASN27 |
| B | CYS28 |
| B | GLY29 |
| B | CYS44 |
| B | HIS47 |
| B | LYS48 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Cationic membrane-docking site (MDoS) => ECO:0000305|PubMed:28751219 |
| Chain | Residue | Details |
| A | ASN16 | |
| B | ASN16 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6, ECO:0000305|PubMed:28751219 |
| Chain | Residue | Details |
| A | LYS19 | |
| B | LYS19 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Important residue of the cationic membrane-docking site (MDoS) => ECO:0000250|UniProtKB:I6L8L6, ECO:0000305|PubMed:28751219 |
| Chain | Residue | Details |
| A | LYS105 | |
| A | ARG108 | |
| B | LYS105 | |
| B | ARG108 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Hydrophobic membrane-disruption site (MDiS) => ECO:0000250|UniProtKB:I6L8L6, ECO:0000305|PubMed:28751219 |
| Chain | Residue | Details |
| A | LEU111 | |
| A | PHE114 | |
| B | LEU111 | |
| B | PHE114 |
