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3MKA

Crystal Structure of Mycobacterium Tuberculosis Proteasome with propetide and an T1A mutation at beta-subunit

Functional Information from GO Data
ChainGOidnamespacecontents
10000502cellular_componentproteasome complex
10004175molecular_functionendopeptidase activity
10004298molecular_functionthreonine-type endopeptidase activity
10005515molecular_functionprotein binding
10005737cellular_componentcytoplasm
10005839cellular_componentproteasome core complex
10005886cellular_componentplasma membrane
10009274cellular_componentpeptidoglycan-based cell wall
10010498biological_processproteasomal protein catabolic process
10019773cellular_componentproteasome core complex, alpha-subunit complex
10019941biological_processmodification-dependent protein catabolic process
10030682biological_processsymbiont-mediated perturbation of host defenses
10043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
10051603biological_processproteolysis involved in protein catabolic process
20000502cellular_componentproteasome complex
20004175molecular_functionendopeptidase activity
20004298molecular_functionthreonine-type endopeptidase activity
20005515molecular_functionprotein binding
20005576cellular_componentextracellular region
20005737cellular_componentcytoplasm
20005839cellular_componentproteasome core complex
20005886cellular_componentplasma membrane
20006508biological_processproteolysis
20008233molecular_functionpeptidase activity
20010498biological_processproteasomal protein catabolic process
20016787molecular_functionhydrolase activity
20019774cellular_componentproteasome core complex, beta-subunit complex
20019941biological_processmodification-dependent protein catabolic process
20030682biological_processsymbiont-mediated perturbation of host defenses
20035375molecular_functionzymogen binding
20043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
20051603biological_processproteolysis involved in protein catabolic process
A0000502cellular_componentproteasome complex
A0004175molecular_functionendopeptidase activity
A0004298molecular_functionthreonine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005839cellular_componentproteasome core complex
A0005886cellular_componentplasma membrane
A0009274cellular_componentpeptidoglycan-based cell wall
A0010498biological_processproteasomal protein catabolic process
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0019941biological_processmodification-dependent protein catabolic process
A0030682biological_processsymbiont-mediated perturbation of host defenses
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051603biological_processproteolysis involved in protein catabolic process
B0000502cellular_componentproteasome complex
B0004175molecular_functionendopeptidase activity
B0004298molecular_functionthreonine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005839cellular_componentproteasome core complex
B0005886cellular_componentplasma membrane
B0009274cellular_componentpeptidoglycan-based cell wall
B0010498biological_processproteasomal protein catabolic process
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0019941biological_processmodification-dependent protein catabolic process
B0030682biological_processsymbiont-mediated perturbation of host defenses
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0051603biological_processproteolysis involved in protein catabolic process
C0000502cellular_componentproteasome complex
C0004175molecular_functionendopeptidase activity
C0004298molecular_functionthreonine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005737cellular_componentcytoplasm
C0005839cellular_componentproteasome core complex
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0008233molecular_functionpeptidase activity
C0010498biological_processproteasomal protein catabolic process
C0016787molecular_functionhydrolase activity
C0019774cellular_componentproteasome core complex, beta-subunit complex
C0019941biological_processmodification-dependent protein catabolic process
C0030682biological_processsymbiont-mediated perturbation of host defenses
C0035375molecular_functionzymogen binding
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0051603biological_processproteolysis involved in protein catabolic process
D0000502cellular_componentproteasome complex
D0004175molecular_functionendopeptidase activity
D0004298molecular_functionthreonine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005839cellular_componentproteasome core complex
D0005886cellular_componentplasma membrane
D0009274cellular_componentpeptidoglycan-based cell wall
D0010498biological_processproteasomal protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0019941biological_processmodification-dependent protein catabolic process
D0030682biological_processsymbiont-mediated perturbation of host defenses
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051603biological_processproteolysis involved in protein catabolic process
E0000502cellular_componentproteasome complex
E0004175molecular_functionendopeptidase activity
E0004298molecular_functionthreonine-type endopeptidase activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005737cellular_componentcytoplasm
E0005839cellular_componentproteasome core complex
E0005886cellular_componentplasma membrane
E0006508biological_processproteolysis
E0008233molecular_functionpeptidase activity
E0010498biological_processproteasomal protein catabolic process
E0016787molecular_functionhydrolase activity
E0019774cellular_componentproteasome core complex, beta-subunit complex
E0019941biological_processmodification-dependent protein catabolic process
E0030682biological_processsymbiont-mediated perturbation of host defenses
E0035375molecular_functionzymogen binding
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0051603biological_processproteolysis involved in protein catabolic process
F0000502cellular_componentproteasome complex
F0004175molecular_functionendopeptidase activity
F0004298molecular_functionthreonine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005839cellular_componentproteasome core complex
F0005886cellular_componentplasma membrane
F0009274cellular_componentpeptidoglycan-based cell wall
F0010498biological_processproteasomal protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0019941biological_processmodification-dependent protein catabolic process
F0030682biological_processsymbiont-mediated perturbation of host defenses
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0051603biological_processproteolysis involved in protein catabolic process
G0000502cellular_componentproteasome complex
G0004175molecular_functionendopeptidase activity
G0004298molecular_functionthreonine-type endopeptidase activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005737cellular_componentcytoplasm
G0005839cellular_componentproteasome core complex
G0005886cellular_componentplasma membrane
G0006508biological_processproteolysis
G0008233molecular_functionpeptidase activity
G0010498biological_processproteasomal protein catabolic process
G0016787molecular_functionhydrolase activity
G0019774cellular_componentproteasome core complex, beta-subunit complex
G0019941biological_processmodification-dependent protein catabolic process
G0030682biological_processsymbiont-mediated perturbation of host defenses
G0035375molecular_functionzymogen binding
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0051603biological_processproteolysis involved in protein catabolic process
H0000502cellular_componentproteasome complex
H0004175molecular_functionendopeptidase activity
H0004298molecular_functionthreonine-type endopeptidase activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005737cellular_componentcytoplasm
H0005839cellular_componentproteasome core complex
H0005886cellular_componentplasma membrane
H0006508biological_processproteolysis
H0008233molecular_functionpeptidase activity
H0010498biological_processproteasomal protein catabolic process
H0016787molecular_functionhydrolase activity
H0019774cellular_componentproteasome core complex, beta-subunit complex
H0019941biological_processmodification-dependent protein catabolic process
H0030682biological_processsymbiont-mediated perturbation of host defenses
H0035375molecular_functionzymogen binding
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0051603biological_processproteolysis involved in protein catabolic process
I0000502cellular_componentproteasome complex
I0004175molecular_functionendopeptidase activity
I0004298molecular_functionthreonine-type endopeptidase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005839cellular_componentproteasome core complex
I0005886cellular_componentplasma membrane
I0009274cellular_componentpeptidoglycan-based cell wall
I0010498biological_processproteasomal protein catabolic process
I0019773cellular_componentproteasome core complex, alpha-subunit complex
I0019941biological_processmodification-dependent protein catabolic process
I0030682biological_processsymbiont-mediated perturbation of host defenses
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0051603biological_processproteolysis involved in protein catabolic process
J0000502cellular_componentproteasome complex
J0004175molecular_functionendopeptidase activity
J0004298molecular_functionthreonine-type endopeptidase activity
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005737cellular_componentcytoplasm
J0005839cellular_componentproteasome core complex
J0005886cellular_componentplasma membrane
J0006508biological_processproteolysis
J0008233molecular_functionpeptidase activity
J0010498biological_processproteasomal protein catabolic process
J0016787molecular_functionhydrolase activity
J0019774cellular_componentproteasome core complex, beta-subunit complex
J0019941biological_processmodification-dependent protein catabolic process
J0030682biological_processsymbiont-mediated perturbation of host defenses
J0035375molecular_functionzymogen binding
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0051603biological_processproteolysis involved in protein catabolic process
K0000502cellular_componentproteasome complex
K0004175molecular_functionendopeptidase activity
K0004298molecular_functionthreonine-type endopeptidase activity
K0005515molecular_functionprotein binding
K0005737cellular_componentcytoplasm
K0005839cellular_componentproteasome core complex
K0005886cellular_componentplasma membrane
K0009274cellular_componentpeptidoglycan-based cell wall
K0010498biological_processproteasomal protein catabolic process
K0019773cellular_componentproteasome core complex, alpha-subunit complex
K0019941biological_processmodification-dependent protein catabolic process
K0030682biological_processsymbiont-mediated perturbation of host defenses
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0051603biological_processproteolysis involved in protein catabolic process
L0000502cellular_componentproteasome complex
L0004175molecular_functionendopeptidase activity
L0004298molecular_functionthreonine-type endopeptidase activity
L0005515molecular_functionprotein binding
L0005576cellular_componentextracellular region
L0005737cellular_componentcytoplasm
L0005839cellular_componentproteasome core complex
L0005886cellular_componentplasma membrane
L0006508biological_processproteolysis
L0008233molecular_functionpeptidase activity
L0010498biological_processproteasomal protein catabolic process
L0016787molecular_functionhydrolase activity
L0019774cellular_componentproteasome core complex, beta-subunit complex
L0019941biological_processmodification-dependent protein catabolic process
L0030682biological_processsymbiont-mediated perturbation of host defenses
L0035375molecular_functionzymogen binding
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0051603biological_processproteolysis involved in protein catabolic process
M0000502cellular_componentproteasome complex
M0004175molecular_functionendopeptidase activity
M0004298molecular_functionthreonine-type endopeptidase activity
M0005515molecular_functionprotein binding
M0005737cellular_componentcytoplasm
M0005839cellular_componentproteasome core complex
M0005886cellular_componentplasma membrane
M0009274cellular_componentpeptidoglycan-based cell wall
M0010498biological_processproteasomal protein catabolic process
M0019773cellular_componentproteasome core complex, alpha-subunit complex
M0019941biological_processmodification-dependent protein catabolic process
M0030682biological_processsymbiont-mediated perturbation of host defenses
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0051603biological_processproteolysis involved in protein catabolic process
N0000502cellular_componentproteasome complex
N0004175molecular_functionendopeptidase activity
N0004298molecular_functionthreonine-type endopeptidase activity
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005737cellular_componentcytoplasm
N0005839cellular_componentproteasome core complex
N0005886cellular_componentplasma membrane
N0006508biological_processproteolysis
N0008233molecular_functionpeptidase activity
N0010498biological_processproteasomal protein catabolic process
N0016787molecular_functionhydrolase activity
N0019774cellular_componentproteasome core complex, beta-subunit complex
N0019941biological_processmodification-dependent protein catabolic process
N0030682biological_processsymbiont-mediated perturbation of host defenses
N0035375molecular_functionzymogen binding
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
N0051603biological_processproteolysis involved in protein catabolic process
O0000502cellular_componentproteasome complex
O0004175molecular_functionendopeptidase activity
O0004298molecular_functionthreonine-type endopeptidase activity
O0005515molecular_functionprotein binding
O0005737cellular_componentcytoplasm
O0005839cellular_componentproteasome core complex
O0005886cellular_componentplasma membrane
O0009274cellular_componentpeptidoglycan-based cell wall
O0010498biological_processproteasomal protein catabolic process
O0019773cellular_componentproteasome core complex, alpha-subunit complex
O0019941biological_processmodification-dependent protein catabolic process
O0030682biological_processsymbiont-mediated perturbation of host defenses
O0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
O0051603biological_processproteolysis involved in protein catabolic process
P0000502cellular_componentproteasome complex
P0004175molecular_functionendopeptidase activity
P0004298molecular_functionthreonine-type endopeptidase activity
P0005515molecular_functionprotein binding
P0005576cellular_componentextracellular region
P0005737cellular_componentcytoplasm
P0005839cellular_componentproteasome core complex
P0005886cellular_componentplasma membrane
P0006508biological_processproteolysis
P0008233molecular_functionpeptidase activity
P0010498biological_processproteasomal protein catabolic process
P0016787molecular_functionhydrolase activity
P0019774cellular_componentproteasome core complex, beta-subunit complex
P0019941biological_processmodification-dependent protein catabolic process
P0030682biological_processsymbiont-mediated perturbation of host defenses
P0035375molecular_functionzymogen binding
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0051603biological_processproteolysis involved in protein catabolic process
Q0000502cellular_componentproteasome complex
Q0004175molecular_functionendopeptidase activity
Q0004298molecular_functionthreonine-type endopeptidase activity
Q0005515molecular_functionprotein binding
Q0005737cellular_componentcytoplasm
Q0005839cellular_componentproteasome core complex
Q0005886cellular_componentplasma membrane
Q0009274cellular_componentpeptidoglycan-based cell wall
Q0010498biological_processproteasomal protein catabolic process
Q0019773cellular_componentproteasome core complex, alpha-subunit complex
Q0019941biological_processmodification-dependent protein catabolic process
Q0030682biological_processsymbiont-mediated perturbation of host defenses
Q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Q0051603biological_processproteolysis involved in protein catabolic process
R0000502cellular_componentproteasome complex
R0004175molecular_functionendopeptidase activity
R0004298molecular_functionthreonine-type endopeptidase activity
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005737cellular_componentcytoplasm
R0005839cellular_componentproteasome core complex
R0005886cellular_componentplasma membrane
R0006508biological_processproteolysis
R0008233molecular_functionpeptidase activity
R0010498biological_processproteasomal protein catabolic process
R0016787molecular_functionhydrolase activity
R0019774cellular_componentproteasome core complex, beta-subunit complex
R0019941biological_processmodification-dependent protein catabolic process
R0030682biological_processsymbiont-mediated perturbation of host defenses
R0035375molecular_functionzymogen binding
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0051603biological_processproteolysis involved in protein catabolic process
S0000502cellular_componentproteasome complex
S0004175molecular_functionendopeptidase activity
S0004298molecular_functionthreonine-type endopeptidase activity
S0005515molecular_functionprotein binding
S0005737cellular_componentcytoplasm
S0005839cellular_componentproteasome core complex
S0005886cellular_componentplasma membrane
S0009274cellular_componentpeptidoglycan-based cell wall
S0010498biological_processproteasomal protein catabolic process
S0019773cellular_componentproteasome core complex, alpha-subunit complex
S0019941biological_processmodification-dependent protein catabolic process
S0030682biological_processsymbiont-mediated perturbation of host defenses
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0051603biological_processproteolysis involved in protein catabolic process
T0000502cellular_componentproteasome complex
T0004175molecular_functionendopeptidase activity
T0004298molecular_functionthreonine-type endopeptidase activity
T0005515molecular_functionprotein binding
T0005576cellular_componentextracellular region
T0005737cellular_componentcytoplasm
T0005839cellular_componentproteasome core complex
T0005886cellular_componentplasma membrane
T0006508biological_processproteolysis
T0008233molecular_functionpeptidase activity
T0010498biological_processproteasomal protein catabolic process
T0016787molecular_functionhydrolase activity
T0019774cellular_componentproteasome core complex, beta-subunit complex
T0019941biological_processmodification-dependent protein catabolic process
T0030682biological_processsymbiont-mediated perturbation of host defenses
T0035375molecular_functionzymogen binding
T0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
T0051603biological_processproteolysis involved in protein catabolic process
U0000502cellular_componentproteasome complex
U0004175molecular_functionendopeptidase activity
U0004298molecular_functionthreonine-type endopeptidase activity
U0005515molecular_functionprotein binding
U0005737cellular_componentcytoplasm
U0005839cellular_componentproteasome core complex
U0005886cellular_componentplasma membrane
U0009274cellular_componentpeptidoglycan-based cell wall
U0010498biological_processproteasomal protein catabolic process
U0019773cellular_componentproteasome core complex, alpha-subunit complex
U0019941biological_processmodification-dependent protein catabolic process
U0030682biological_processsymbiont-mediated perturbation of host defenses
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
U0051603biological_processproteolysis involved in protein catabolic process
V0000502cellular_componentproteasome complex
V0004175molecular_functionendopeptidase activity
V0004298molecular_functionthreonine-type endopeptidase activity
V0005515molecular_functionprotein binding
V0005576cellular_componentextracellular region
V0005737cellular_componentcytoplasm
V0005839cellular_componentproteasome core complex
V0005886cellular_componentplasma membrane
V0006508biological_processproteolysis
V0008233molecular_functionpeptidase activity
V0010498biological_processproteasomal protein catabolic process
V0016787molecular_functionhydrolase activity
V0019774cellular_componentproteasome core complex, beta-subunit complex
V0019941biological_processmodification-dependent protein catabolic process
V0030682biological_processsymbiont-mediated perturbation of host defenses
V0035375molecular_functionzymogen binding
V0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
V0051603biological_processproteolysis involved in protein catabolic process
W0000502cellular_componentproteasome complex
W0004175molecular_functionendopeptidase activity
W0004298molecular_functionthreonine-type endopeptidase activity
W0005515molecular_functionprotein binding
W0005737cellular_componentcytoplasm
W0005839cellular_componentproteasome core complex
W0005886cellular_componentplasma membrane
W0009274cellular_componentpeptidoglycan-based cell wall
W0010498biological_processproteasomal protein catabolic process
W0019773cellular_componentproteasome core complex, alpha-subunit complex
W0019941biological_processmodification-dependent protein catabolic process
W0030682biological_processsymbiont-mediated perturbation of host defenses
W0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0051603biological_processproteolysis involved in protein catabolic process
X0000502cellular_componentproteasome complex
X0004175molecular_functionendopeptidase activity
X0004298molecular_functionthreonine-type endopeptidase activity
X0005515molecular_functionprotein binding
X0005576cellular_componentextracellular region
X0005737cellular_componentcytoplasm
X0005839cellular_componentproteasome core complex
X0005886cellular_componentplasma membrane
X0006508biological_processproteolysis
X0008233molecular_functionpeptidase activity
X0010498biological_processproteasomal protein catabolic process
X0016787molecular_functionhydrolase activity
X0019774cellular_componentproteasome core complex, beta-subunit complex
X0019941biological_processmodification-dependent protein catabolic process
X0030682biological_processsymbiont-mediated perturbation of host defenses
X0035375molecular_functionzymogen binding
X0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
X0051603biological_processproteolysis involved in protein catabolic process
Y0000502cellular_componentproteasome complex
Y0004175molecular_functionendopeptidase activity
Y0004298molecular_functionthreonine-type endopeptidase activity
Y0005515molecular_functionprotein binding
Y0005737cellular_componentcytoplasm
Y0005839cellular_componentproteasome core complex
Y0005886cellular_componentplasma membrane
Y0009274cellular_componentpeptidoglycan-based cell wall
Y0010498biological_processproteasomal protein catabolic process
Y0019773cellular_componentproteasome core complex, alpha-subunit complex
Y0019941biological_processmodification-dependent protein catabolic process
Y0030682biological_processsymbiont-mediated perturbation of host defenses
Y0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Y0051603biological_processproteolysis involved in protein catabolic process
Z0000502cellular_componentproteasome complex
Z0004175molecular_functionendopeptidase activity
Z0004298molecular_functionthreonine-type endopeptidase activity
Z0005515molecular_functionprotein binding
Z0005576cellular_componentextracellular region
Z0005737cellular_componentcytoplasm
Z0005839cellular_componentproteasome core complex
Z0005886cellular_componentplasma membrane
Z0006508biological_processproteolysis
Z0008233molecular_functionpeptidase activity
Z0010498biological_processproteasomal protein catabolic process
Z0016787molecular_functionhydrolase activity
Z0019774cellular_componentproteasome core complex, beta-subunit complex
Z0019941biological_processmodification-dependent protein catabolic process
Z0030682biological_processsymbiont-mediated perturbation of host defenses
Z0035375molecular_functionzymogen binding
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Z0051603biological_processproteolysis involved in protein catabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues28
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"25224505","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"N-acetylserine; partial","evidences":[{"source":"PubMed","id":"17259624","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21969609","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues14
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"20711362","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues14
DetailsSite: {"description":"Covalent link with the inhibitor MLN-273","evidences":[{"source":"PubMed","id":"16468986","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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