3MJD

1.9 Angstrom Crystal Structure of Orotate Phosphoribosyltransferase (pyrE) Francisella tularensis.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004588	molecular_function	orotate phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0016757	molecular_function	glycosyltransferase activity
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0072528	biological_process	pyrimidine-containing compound biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004588	molecular_function	orotate phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0016757	molecular_function	glycosyltransferase activity
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0072528	biological_process	pyrimidine-containing compound biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004588	molecular_function	orotate phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0016757	molecular_function	glycosyltransferase activity
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
C	0055086	biological_process	nucleobase-containing small molecule metabolic process
C	0072528	biological_process	pyrimidine-containing compound biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004588	molecular_function	orotate phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0016757	molecular_function	glycosyltransferase activity
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046132	biological_process	pyrimidine ribonucleoside biosynthetic process
D	0055086	biological_process	nucleobase-containing small molecule metabolic process
D	0072528	biological_process	pyrimidine-containing compound biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO C 209

Chain	Residue
B	GLU16
B	PHE17
B	THR18
C	LYS13
C	PHE28
C	ASN30
C	HOH388
C	HOH561

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TRS C 210

Chain	Residue
C	ASN9
C	LEU33
C	ASN35
C	THR36
C	GLN39
B	GLU16

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Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLLIDDVMTAGtA

Chain	Residue	Details
A	VAL115-ALA127

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