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3MHH

Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module

Functional Information from GO Data
ChainGOidnamespacecontents
A0000124cellular_componentSAGA complex
A0004843molecular_functioncysteine-type deubiquitinase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0006357biological_processregulation of transcription by RNA polymerase II
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008234molecular_functioncysteine-type peptidase activity
A0008270molecular_functionzinc ion binding
A0008380biological_processRNA splicing
A0016579biological_processprotein deubiquitination
A0016787molecular_functionhydrolase activity
A0046695cellular_componentSLIK (SAGA-like) complex
A0046872molecular_functionmetal ion binding
A0060090molecular_functionmolecular adaptor activity
A0071819cellular_componentDUBm complex
B0000124cellular_componentSAGA complex
B0000932cellular_componentP-body
B0000973biological_processpost-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
B0003682molecular_functionchromatin binding
B0003713molecular_functiontranscription coactivator activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005643cellular_componentnuclear pore
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0006325biological_processchromatin organization
B0006357biological_processregulation of transcription by RNA polymerase II
B0006368biological_processtranscription elongation by RNA polymerase II
B0006406biological_processmRNA export from nucleus
B0008047molecular_functionenzyme activator activity
B0015031biological_processprotein transport
B0016973biological_processpoly(A)+ mRNA export from nucleus
B0032880biological_processregulation of protein localization
B0043229cellular_componentintracellular organelle
B0045893biological_processpositive regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046695cellular_componentSLIK (SAGA-like) complex
B0051028biological_processmRNA transport
B0070390cellular_componenttranscription export complex 2
B0071028biological_processnuclear mRNA surveillance
B0071819cellular_componentDUBm complex
C0000124cellular_componentSAGA complex
C0003713molecular_functiontranscription coactivator activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0006325biological_processchromatin organization
C0006357biological_processregulation of transcription by RNA polymerase II
C0008047molecular_functionenzyme activator activity
C0008270molecular_functionzinc ion binding
C0045893biological_processpositive regulation of DNA-templated transcription
C0046695cellular_componentSLIK (SAGA-like) complex
C0046872molecular_functionmetal ion binding
C0070461cellular_componentSAGA-type complex
C0071819cellular_componentDUBm complex
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 472
ChainResidue
ACYS4
AHIS6
ACYS96
ACYS99

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 473
ChainResidue
ACYS46
ACYS49
ACYS68
AHIS73

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 474
ChainResidue
ACYS63
AHIS77
AHIS83
ACYS60

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 475
ChainResidue
AHIS170
ACYS174
ACYS182
ACYS185

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 476
ChainResidue
AHIS250
ACYS271
ACYS273
AHIS276

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 100
ChainResidue
CCYS73
CCYS76
CHIS88
CCYS92

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 97
ChainResidue
ECYS78
ECYS81
EHIS93
EHOH163

Functional Information from PROSITE/UniProt
site_idPS00972
Number of Residues16
DetailsUSP_1 Ubiquitin specific protease (USP) domain signature 1. GLinmGStCFMSSiLQ
ChainResidueDetails
AGLY138-GLN153

site_idPS00973
Number of Residues18
DetailsUSP_2 Ubiquitin specific protease (USP) domain signature 2. YeLiGIvsHkGtvne..GHY
ChainResidueDetails
ATYR411-TYR428

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues21
DetailsZN_FING: SGF11-type => ECO:0000255|HAMAP-Rule:MF_03047
ChainResidueDetails
CILE71-CYS92

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Nucleophile
ChainResidueDetails
ACYS146

site_idSWS_FT_FI3
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093
ChainResidueDetails
AHIS427

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00502
ChainResidueDetails
ACYS46
ACYS49
ACYS60
ACYS63
ACYS68
AHIS73
AHIS77
AHIS83

218853

PDB entries from 2024-04-24

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