3MH6

HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006457	biological_process	protein folding
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0006979	biological_process	response to oxidative stress
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009266	biological_process	response to temperature stimulus
A	0009408	biological_process	response to heat
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0042597	cellular_component	periplasmic space
A	0042802	molecular_function	identical protein binding
A	0061077	biological_process	chaperone-mediated protein folding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DFP A 500

Chain	Residue
A	LEU87
A	ILE228
A	HIS105
A	ASN206
A	ARG207
A	GLY208
A	ASN209
A	SER210
A	THR226
A	ALA227

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000269|PubMed:20581825

Chain	Residue	Details
A	HIS105
A	ASP135
A	SER210

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	GLU32
A	HIS105
A	ASP135
A	GLY208
A	THR226
A	LEU265

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