3MH6
HtrA proteases are activated by a conserved mechanism that can be triggered by distinct molecular cues
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006457 | biological_process | protein folding |
| A | 0006508 | biological_process | proteolysis |
| A | 0006515 | biological_process | protein quality control for misfolded or incompletely synthesized proteins |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0009266 | biological_process | response to temperature stimulus |
| A | 0009408 | biological_process | response to heat |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE DFP A 500 |
| Chain | Residue |
| A | LEU87 |
| A | ILE228 |
| A | HIS105 |
| A | ASN206 |
| A | ARG207 |
| A | GLY208 |
| A | ASN209 |
| A | SER210 |
| A | THR226 |
| A | ALA227 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 91 |
| Details | Domain: {"description":"PDZ 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 89 |
| Details | Domain: {"description":"PDZ 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"20581825","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 13 |
| Details | Binding site: {} |
| Chain | Residue | Details |
