3MFS

CASK-4M CaM Kinase Domain, AMPPNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ANP A 500

Chain	Residue
A	GLY21
A	LEU148
A	ASP162
A	HOH338
A	HOH339
A	HOH371
A	HOH382
A	HOH397
A	HOH459
A	ALA22
A	SER24
A	VAL26
A	ALA39
A	LYS41
A	VAL75
A	GLU92
A	MET94

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGAFSVVRrCinretgqq..........FAVK

Chain	Residue	Details
A	ILE18-LYS41

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDVKpeNVLL

Chain	Residue	Details
A	ILE137-LEU149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	ASP141

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00100, ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE18

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LYS41

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER51

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:18423203

Chain	Residue	Details
A	SER151
A	SER155

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O70589

Chain	Residue	Details
A	THR182

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER313

---