3MEN
Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0040029 | biological_process | epigenetic regulation of gene expression |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047609 | molecular_function | acetylputrescine deacetylase activity |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0040029 | biological_process | epigenetic regulation of gene expression |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047609 | molecular_function | acetylputrescine deacetylase activity |
| C | 0004407 | molecular_function | histone deacetylase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0040029 | biological_process | epigenetic regulation of gene expression |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047609 | molecular_function | acetylputrescine deacetylase activity |
| D | 0004407 | molecular_function | histone deacetylase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0040029 | biological_process | epigenetic regulation of gene expression |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0047609 | molecular_function | acetylputrescine deacetylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 400 |
| Chain | Residue |
| A | ASP192 |
| A | HIS194 |
| A | ASP281 |
| A | SO4401 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | ASP281 |
| A | TYR320 |
| A | ZN400 |
| A | HIS156 |
| A | HIS157 |
| A | GLY165 |
| A | ASP192 |
| A | HIS194 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 402 |
| Chain | Residue |
| A | ASP190 |
| A | ASP192 |
| A | HIS194 |
| A | SER213 |
| A | ILE214 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 343 |
| Chain | Residue |
| A | HIS13 |
| A | GLU120 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 345 |
| Chain | Residue |
| A | SER19 |
| A | ARG20 |
| B | ASN91 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 346 |
| Chain | Residue |
| A | ASN91 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 347 |
| Chain | Residue |
| A | SER19 |
| A | SER115 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 348 |
| Chain | Residue |
| A | GLN106 |
| A | HOH453 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 349 |
| Chain | Residue |
| A | HOH480 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 400 |
| Chain | Residue |
| C | ASP192 |
| C | HIS194 |
| C | ASP281 |
| C | SO4401 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 401 |
| Chain | Residue |
| C | HIS156 |
| C | HIS157 |
| C | GLY165 |
| C | ASP192 |
| C | HIS194 |
| C | ASP281 |
| C | GLY318 |
| C | TYR320 |
| C | ZN400 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K C 402 |
| Chain | Residue |
| C | ASP190 |
| C | ASP192 |
| C | HIS194 |
| C | SER213 |
| C | ILE214 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 342 |
| Chain | Residue |
| C | PRO247 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD C 343 |
| Chain | Residue |
| C | HIS13 |
| C | GLU120 |
| C | HIS121 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD C 344 |
| Chain | Residue |
| C | THR72 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 345 |
| Chain | Residue |
| C | SER19 |
| D | ASN91 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD C 348 |
| Chain | Residue |
| C | SER19 |
| C | SER115 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 400 |
| Chain | Residue |
| B | ASP192 |
| B | HIS194 |
| B | ASP281 |
| B | SO4401 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 401 |
| Chain | Residue |
| B | HIS156 |
| B | HIS157 |
| B | GLY165 |
| B | ASP192 |
| B | HIS194 |
| B | ASP281 |
| B | TYR320 |
| B | ZN400 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 402 |
| Chain | Residue |
| B | ASP190 |
| B | ASP192 |
| B | HIS194 |
| B | SER213 |
| B | ILE214 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 403 |
| Chain | Residue |
| B | ARG22 |
| B | ARG24 |
| B | MET25 |
| B | HOH483 |
| D | ARG48 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 344 |
| Chain | Residue |
| B | HIS13 |
| B | GLU120 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 347 |
| Chain | Residue |
| B | SER115 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD B 348 |
| Chain | Residue |
| B | GLN200 |
| B | HOH424 |
| site_id | CC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD B 350 |
| Chain | Residue |
| B | HOH420 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 400 |
| Chain | Residue |
| D | ASP192 |
| D | HIS194 |
| D | ASP281 |
| D | SO4401 |
| site_id | CC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D 401 |
| Chain | Residue |
| D | HIS156 |
| D | HIS157 |
| D | GLY165 |
| D | ASP192 |
| D | HIS194 |
| D | ASP281 |
| D | TYR320 |
| D | ZN400 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K D 402 |
| Chain | Residue |
| D | ILE214 |
| D | ASP190 |
| D | ASP192 |
| D | HIS194 |
| D | SER213 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 403 |
| Chain | Residue |
| D | ARG24 |
| D | MET25 |
| site_id | DC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 343 |
| Chain | Residue |
| D | SER19 |
| site_id | DC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 346 |
| Chain | Residue |
| D | HIS13 |
| site_id | DC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD D 347 |
| Chain | Residue |
| D | HOH360 |
| site_id | DC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD D 349 |
| Chain | Residue |
| D | SER19 |
| D | SER115 |
| site_id | DC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD D 350 |
| Chain | Residue |
| D | ARG141 |
| D | LEU179 |
| D | ARG182 |
| D | HIS183 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21359836","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MEN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Polarizes the scissile carbonyl of the substrate","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
