Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3MEN

Crystal structure of acetylpolyamine aminohydrolase from Burkholderia pseudomallei, iodide soak

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004407	molecular_function	histone deacetylase activity
A	0006338	biological_process	chromatin remodeling
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0047609	molecular_function	acetylputrescine deacetylase activity
B	0004407	molecular_function	histone deacetylase activity
B	0006338	biological_process	chromatin remodeling
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0047609	molecular_function	acetylputrescine deacetylase activity
C	0004407	molecular_function	histone deacetylase activity
C	0006338	biological_process	chromatin remodeling
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0047609	molecular_function	acetylputrescine deacetylase activity
D	0004407	molecular_function	histone deacetylase activity
D	0006338	biological_process	chromatin remodeling
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0047609	molecular_function	acetylputrescine deacetylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	ASP192
A	HIS194
A	ASP281
A	SO4401

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 401

Chain	Residue
A	ASP281
A	TYR320
A	ZN400
A	HIS156
A	HIS157
A	GLY165
A	ASP192
A	HIS194

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 402

Chain	Residue
A	ASP190
A	ASP192
A	HIS194
A	SER213
A	ILE214

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 343

Chain	Residue
A	HIS13
A	GLU120

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 345

Chain	Residue
A	SER19
A	ARG20
B	ASN91

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 346

Chain	Residue
A	ASN91

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 347

Chain	Residue
A	SER19
A	SER115

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 348

Chain	Residue
A	GLN106
A	HOH453

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 349

Chain	Residue
A	HOH480

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 400

Chain	Residue
C	ASP192
C	HIS194
C	ASP281
C	SO4401

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 401

Chain	Residue
C	HIS156
C	HIS157
C	GLY165
C	ASP192
C	HIS194
C	ASP281
C	GLY318
C	TYR320
C	ZN400

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 402

Chain	Residue
C	ASP190
C	ASP192
C	HIS194
C	SER213
C	ILE214

site_id	BC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD C 342

Chain	Residue
C	PRO247

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD C 343

Chain	Residue
C	HIS13
C	GLU120
C	HIS121

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD C 344

Chain	Residue
C	THR72

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD C 345

Chain	Residue
C	SER19
D	ASN91

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD C 348

Chain	Residue
C	SER19
C	SER115

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 400

Chain	Residue
B	ASP192
B	HIS194
B	ASP281
B	SO4401

site_id	CC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 401

Chain	Residue
B	HIS156
B	HIS157
B	GLY165
B	ASP192
B	HIS194
B	ASP281
B	TYR320
B	ZN400

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K B 402

Chain	Residue
B	ASP190
B	ASP192
B	HIS194
B	SER213
B	ILE214

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 403

Chain	Residue
B	ARG22
B	ARG24
B	MET25
B	HOH483
D	ARG48

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD B 344

Chain	Residue
B	HIS13
B	GLU120

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 347

Chain	Residue
B	SER115

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD B 348

Chain	Residue
B	GLN200
B	HOH424

site_id	CC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 350

Chain	Residue
B	HOH420

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 400

Chain	Residue
D	ASP192
D	HIS194
D	ASP281
D	SO4401

site_id	CC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 401

Chain	Residue
D	HIS156
D	HIS157
D	GLY165
D	ASP192
D	HIS194
D	ASP281
D	TYR320
D	ZN400

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K D 402

Chain	Residue
D	ILE214
D	ASP190
D	ASP192
D	HIS194
D	SER213

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 403

Chain	Residue
D	ARG24
D	MET25

site_id	DC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 343

Chain	Residue
D	SER19

site_id	DC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 346

Chain	Residue
D	HIS13

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 347

Chain	Residue
D	HOH360

site_id	DC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD D 349

Chain	Residue
D	SER19
D	SER115

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD D 350

Chain	Residue
D	ARG141
D	LEU179
D	ARG182
D	HIS183

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250\|UniProtKB:Q48935

Chain	Residue	Details
A	HIS157
B	HIS157
C	HIS157
D	HIS157

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:21359836, ECO:0007744\|PDB:3MEN

Chain	Residue	Details
A	ASP192
D	ASP192
D	HIS194
D	ASP281
A	HIS194
A	ASP281
B	ASP192
B	HIS194
B	ASP281
C	ASP192
C	HIS194
C	ASP281

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Polarizes the scissile carbonyl of the substrate => ECO:0000250\|UniProtKB:Q48935

Chain	Residue	Details
A	TYR320
B	TYR320
C	TYR320
D	TYR320

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)