3MDW

The structure of N-formimino-L-Glutamate Iminohydrolase from Pseudomonas aeruginosa complexed with N-formimino-L-Aspartate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006547	biological_process	L-histidine metabolic process
A	0006548	biological_process	L-histidine catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0019239	molecular_function	deaminase activity
A	0019556	biological_process	L-histidine catabolic process to glutamate and formamide
A	0019557	biological_process	L-histidine catabolic process to glutamate and formate
A	0046872	molecular_function	metal ion binding
A	0050416	molecular_function	formimidoylglutamate deiminase activity
B	0005829	cellular_component	cytosol
B	0006547	biological_process	L-histidine metabolic process
B	0006548	biological_process	L-histidine catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0019239	molecular_function	deaminase activity
B	0019556	biological_process	L-histidine catabolic process to glutamate and formamide
B	0019557	biological_process	L-histidine catabolic process to glutamate and formate
B	0046872	molecular_function	metal ion binding
B	0050416	molecular_function	formimidoylglutamate deiminase activity
C	0005829	cellular_component	cytosol
C	0006547	biological_process	L-histidine metabolic process
C	0006548	biological_process	L-histidine catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C	0019239	molecular_function	deaminase activity
C	0019556	biological_process	L-histidine catabolic process to glutamate and formamide
C	0019557	biological_process	L-histidine catabolic process to glutamate and formate
C	0046872	molecular_function	metal ion binding
C	0050416	molecular_function	formimidoylglutamate deiminase activity
D	0005829	cellular_component	cytosol
D	0006547	biological_process	L-histidine metabolic process
D	0006548	biological_process	L-histidine catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0019239	molecular_function	deaminase activity
D	0019556	biological_process	L-histidine catabolic process to glutamate and formamide
D	0019557	biological_process	L-histidine catabolic process to glutamate and formate
D	0046872	molecular_function	metal ion binding
D	0050416	molecular_function	formimidoylglutamate deiminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NFQ A 454

Chain	Residue
A	HIS58
A	ASP320
A	HOH505
A	HOH508
A	HOH539
A	HOH568
A	HOH1026
A	GLN61
A	PHE78
A	ARG82
A	TYR121
A	HIS206
A	ARG209
A	GLU235
A	LEU298

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NFQ B 454

Chain	Residue
B	GLN61
B	PHE78
B	ARG82
B	TYR121
B	HIS206
B	ARG209
B	GLU235
B	LEU298
B	ASP320
B	HOH495
B	HOH554
B	HOH564
B	HOH599
B	HOH1021

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NFQ C 454

Chain	Residue
C	HIS58
C	GLN61
C	ARG82
C	TYR121
C	HIS206
C	ARG209
C	GLU235
C	LEU298
C	ASP320
C	HOH489
C	HOH524
C	HOH539
C	HOH540
C	HOH1024

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NFQ D 454

Chain	Residue
D	HIS58
D	GLN61
D	PHE78
D	ARG82
D	TYR121
D	HIS206
D	ARG209
D	GLU235
D	LEU298
D	ASP320
D	HOH511
D	HOH517
D	HOH526
D	HOH577
D	HOH1023

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 455

Chain	Residue
A	HIS56
A	HIS58
A	HIS232
A	ASP320
A	HOH1026

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 455

Chain	Residue
B	HIS56
B	HIS58
B	HIS232
B	ASP320
B	HOH1021

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 455

Chain	Residue
C	HIS56
C	HIS58
C	HIS232
C	ASP320
C	HOH1024

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 455

Chain	Residue
D	HIS56
D	HIS58
D	HIS232
D	ASP320
D	HOH1023

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 456

Chain	Residue
A	GLY179
A	GLU181
A	ALA182
A	HOH533
A	HOH809
C	HIS161
C	THR212
C	GLN214
C	GLN215

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 456

Chain	Residue
A	LEU11
A	PRO12
A	ARG358
A	ASP362
A	GLY377
A	SER378
A	HOH469
A	HOH483

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 D 456

Chain	Residue
D	HIS161
D	THR212
D	GLN214
D	GLN215
D	HOH798
B	GLY179
B	GLU181
B	ALA182
B	HOH812

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17128965","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25559274","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25559274","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RZB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25559274","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3MDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RZB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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