3MDO
Crystal structure of a Putative phosphoribosylformylglycinamidine cyclo-ligase (BDI_2101) from Parabacteroides distasonis ATCC 8503 at 1.91 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004637 | molecular_function | phosphoribosylamine-glycine ligase activity |
| A | 0004641 | molecular_function | phosphoribosylformylglycinamidine cyclo-ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046084 | biological_process | adenine biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004637 | molecular_function | phosphoribosylamine-glycine ligase activity |
| B | 0004641 | molecular_function | phosphoribosylformylglycinamidine cyclo-ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0046084 | biological_process | adenine biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 389 |
| Chain | Residue |
| A | GLN322 |
| A | HOH579 |
| A | HOH580 |
| A | HOH581 |
| A | HOH582 |
| A | HOH583 |
| A | HOH584 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 390 |
| Chain | Residue |
| A | HOH552 |
| B | GLU146 |
| B | HOH617 |
| A | ASP55 |
| A | HOH519 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 391 |
| Chain | Residue |
| A | ASP55 |
| A | ASP91 |
| A | PGE403 |
| A | HOH621 |
| A | HOH630 |
| B | HOH593 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 392 |
| Chain | Residue |
| A | GLU146 |
| A | HOH566 |
| A | HOH595 |
| B | ASP55 |
| B | ACT395 |
| B | HOH595 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 393 |
| Chain | Residue |
| A | LYS111 |
| A | GLY151 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 394 |
| Chain | Residue |
| A | ASN335 |
| A | HOH451 |
| A | HOH606 |
| A | HOH629 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 395 |
| Chain | Residue |
| A | SER105 |
| A | ILE107 |
| A | GLY144 |
| A | GLY145 |
| A | GLU146 |
| A | THR147 |
| A | HOH490 |
| A | HOH645 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG A 396 |
| Chain | Residue |
| A | ILE29 |
| A | PHE30 |
| A | LYS176 |
| A | HOH468 |
| A | HOH558 |
| B | THR387 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 397 |
| Chain | Residue |
| A | GLN320 |
| A | ASP326 |
| A | TRP327 |
| A | SER328 |
| A | PHE386 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG A 398 |
| Chain | Residue |
| A | GLU300 |
| A | ASN301 |
| A | LYS374 |
| A | ASN375 |
| B | GLY43 |
| B | GLY44 |
| B | PRO46 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 399 |
| Chain | Residue |
| A | GLY181 |
| A | VAL369 |
| A | PGE402 |
| A | HOH435 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 400 |
| Chain | Residue |
| A | LYS243 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PEG A 401 |
| Chain | Residue |
| A | SER170 |
| A | VAL172 |
| A | ILE173 |
| A | ARG278 |
| A | ILE281 |
| A | HOH415 |
| A | HOH418 |
| A | HOH425 |
| A | HOH596 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE A 402 |
| Chain | Residue |
| A | PHE368 |
| A | PEG399 |
| A | HOH574 |
| B | SER217 |
| B | GLY240 |
| B | HOH463 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PGE A 403 |
| Chain | Residue |
| A | PHE34 |
| A | HIS53 |
| A | ASP91 |
| A | LYS294 |
| A | HIS297 |
| A | CA391 |
| B | HOH593 |
| site_id | BC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE P6G A 404 |
| Chain | Residue |
| A | THR209 |
| A | SER210 |
| A | HIS213 |
| A | ASP214 |
| A | SER323 |
| A | THR325 |
| A | HOH438 |
| A | HOH485 |
| A | HOH561 |
| B | HOH425 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 389 |
| Chain | Residue |
| B | HOH616 |
| A | HOH588 |
| B | ASP55 |
| B | ASP91 |
| B | ACT395 |
| B | HOH522 |
| B | HOH564 |
| site_id | BC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 390 |
| Chain | Residue |
| B | GLN322 |
| B | CAC394 |
| B | HOH582 |
| B | HOH583 |
| B | HOH584 |
| B | HOH585 |
| B | HOH586 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 391 |
| Chain | Residue |
| B | GLY145 |
| B | HOH447 |
| B | HOH448 |
| B | HOH449 |
| B | HOH450 |
| B | HOH459 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 392 |
| Chain | Residue |
| B | LYS111 |
| B | ASP149 |
| B | VAL150 |
| B | GLY151 |
| B | HOH485 |
| B | HOH598 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 393 |
| Chain | Residue |
| B | MSE203 |
| B | ASN335 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CAC B 394 |
| Chain | Residue |
| A | ARG303 |
| A | ARG385 |
| B | ASP214 |
| B | SER239 |
| B | GLN322 |
| B | SER323 |
| B | CA390 |
| site_id | CC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACT B 395 |
| Chain | Residue |
| A | CA392 |
| B | ASP55 |
| B | MSE87 |
| B | ASN206 |
| B | SER288 |
| B | GLY289 |
| B | CA389 |
| B | HOH522 |
| B | HOH616 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 396 |
| Chain | Residue |
| B | THR209 |
| B | HIS213 |
| B | ASP214 |
| B | VAL232 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 397 |
| Chain | Residue |
| B | ASP40 |
| B | ILE41 |
| B | PRO46 |
| B | HOH423 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG B 398 |
| Chain | Residue |
| B | TYR195 |
| site_id | CC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG B 399 |
| Chain | Residue |
| A | THR71 |
| B | LYS276 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 400 |
| Chain | Residue |
| A | ASN177 |
| A | GLN179 |
| B | ARG385 |
| B | THR387 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGE B 401 |
| Chain | Residue |
| A | MSE136 |
| A | THR194 |
| A | SER358 |
| A | PHE359 |
| B | LYS111 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGE B 402 |
| Chain | Residue |
| B | PHE34 |
| B | HIS53 |
| B | ASP91 |
| B | GLY289 |
| B | LYS294 |
| B | HIS297 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGE B 403 |
| Chain | Residue |
| B | LEU242 |
| B | GLU321 |
| B | GLN322 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PG4 B 404 |
| Chain | Residue |
| B | GLU70 |
| B | TYR219 |
| B | LYS243 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 B 405 |
| Chain | Residue |
| A | GLU132 |
| A | THR194 |
| B | LYS69 |
| B | LYS111 |
| B | LEU112 |
| B | HOH484 |
