3MDB
Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005911 | cellular_component | cell-cell junction |
| B | 0005911 | cellular_component | cell-cell junction |
| C | 0005096 | molecular_function | GTPase activator activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005547 | molecular_function | phosphatidylinositol-3,4,5-trisphosphate binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007166 | biological_process | cell surface receptor signaling pathway |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0043087 | biological_process | regulation of GTPase activity |
| C | 0043533 | molecular_function | inositol 1,3,4,5 tetrakisphosphate binding |
| C | 0043547 | biological_process | positive regulation of GTPase activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 1902936 | molecular_function | phosphatidylinositol bisphosphate binding |
| D | 0005096 | molecular_function | GTPase activator activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005547 | molecular_function | phosphatidylinositol-3,4,5-trisphosphate binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0007166 | biological_process | cell surface receptor signaling pathway |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0043087 | biological_process | regulation of GTPase activity |
| D | 0043533 | molecular_function | inositol 1,3,4,5 tetrakisphosphate binding |
| D | 0043547 | biological_process | positive regulation of GTPase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 1902936 | molecular_function | phosphatidylinositol bisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 401 |
| Chain | Residue |
| C | CYS21 |
| C | CYS24 |
| C | CYS41 |
| C | CYS44 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 401 |
| Chain | Residue |
| D | CYS21 |
| D | CYS24 |
| D | CYS41 |
| D | CYS44 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE IP9 C 375 |
| Chain | Residue |
| C | LYS138 |
| C | GLY140 |
| C | ARG141 |
| C | ARG149 |
| C | TYR162 |
| C | ASN164 |
| C | LYS172 |
| C | ARG206 |
| A | TYR466 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 64 |
| Details | Domain: {"description":"FHA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 238 |
| Details | Domain: {"description":"Arf-GAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00288","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 46 |
| Details | Zinc finger: {"description":"C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00288","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"12893243","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"12893243","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
