3M9E

Thyroid hormone beta DNA binding domain homodimer with inverted palindrome TRE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0004879	molecular_function	nuclear receptor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0043565	molecular_function	sequence-specific DNA binding
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0004879	molecular_function	nuclear receptor activity
E	0006355	biological_process	regulation of DNA-templated transcription
E	0008270	molecular_function	zinc ion binding
E	0043565	molecular_function	sequence-specific DNA binding
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0004879	molecular_function	nuclear receptor activity
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008270	molecular_function	zinc ion binding
F	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 208

Chain	Residue
A	CYS106
A	CYS109
A	CYS123
A	CYS126

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 209

Chain	Residue
A	CYS144
A	CYS150
A	CYS160
A	CYS163

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 208

Chain	Residue
B	CYS109
B	CYS123
B	CYS126
B	CYS106

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 209

Chain	Residue
B	CYS144
B	CYS150
B	CYS160
B	CYS163

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 208

Chain	Residue
E	CYS106
E	CYS109
E	CYS123
E	CYS126

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 209

Chain	Residue
E	CYS144
E	CYS150
E	CYS160
E	CYS163

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN F 208

Chain	Residue
F	CYS106
F	CYS109
F	ASP111
F	CYS123
F	CYS126

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 209

Chain	Residue
F	CYS144
F	CYS150
F	CYS160
F	CYS163

---

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CvvCg.Dkatgy.HYrcitCegCkgFFrR

Chain	Residue	Details
A	CYS106-ARG132

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	296
Details	DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	CYS106-ASP180
B	CYS106-ASP180
E	CYS106-ASP180
F	CYS106-ASP180

---

site_id	SWS_FT_FI2
Number of Residues	176
Details	ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	CYS106-CYS126
A	CYS144-CYS168
B	CYS106-CYS126
B	CYS144-CYS168
E	CYS106-CYS126
E	CYS144-CYS168
F	CYS106-CYS126
F	CYS144-CYS168

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P10828

Chain	Residue	Details
A	CYS106
B	CYS109
B	CYS123
B	CYS126
B	CYS144
B	CYS150
B	CYS160
B	CYS163
E	CYS106
E	CYS109
E	CYS123
A	CYS109
E	CYS126
E	CYS144
E	CYS150
E	CYS160
E	CYS163
F	CYS106
F	CYS109
F	CYS123
F	CYS126
F	CYS144
A	CYS123
F	CYS150
F	CYS160
F	CYS163
A	CYS126
A	CYS144
A	CYS150
A	CYS160
A	CYS163
B	CYS106

---