3M86
Crystal structure of the cysteine protease inhibitor, EhICP2, from Entamoeba histolytica
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030162 | biological_process | regulation of proteolysis |
| A | 0030414 | molecular_function | peptidase inhibitor activity |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0045335 | cellular_component | phagocytic vesicle |
| B | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005764 | cellular_component | lysosome |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0030162 | biological_process | regulation of proteolysis |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0045335 | cellular_component | phagocytic vesicle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 1PE B 1 |
| Chain | Residue |
| B | PHE34 |
| B | THR48 |
| B | TYR50 |
| B | VAL93 |
| B | TYR102 |
| B | LEU113 |
| B | HOH129 |
| B | HOH131 |
| B | HOH204 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1 |
| Chain | Residue |
| A | THR44 |
| A | ALA51 |
| A | TRP52 |
| A | ARG84 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 2 |
| Chain | Residue |
| B | THR44 |
| B | TRP52 |
| B | ARG84 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 124 |
| Chain | Residue |
| B | TRP52 |
| B | ASN53 |
| B | ILE54 |
| B | ARG84 |
| B | HOH200 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 125 |
| Chain | Residue |
| B | LYS89 |
| B | LEU113 |
| B | ARG114 |
| B | SER115 |
| B | HOH173 |
| B | HOH180 |
| B | HOH186 |
| B | HOH188 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Motif: {"description":"BC loop","evidences":[{"source":"PubMed","id":"20951777","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32731033","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Motif: {"description":"DE loop","evidences":[{"source":"PubMed","id":"20951777","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Motif: {"description":"FG loop","evidences":[{"source":"PubMed","id":"20951777","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
