3M5M

Avoiding drug resistance against HCV NS3/4A protease inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	symbiont-mediated transformation of host cell
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
B	0019087	biological_process	symbiont-mediated transformation of host cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MES A 1

Chain	Residue
A	HOH195
B	ASP1112
B	TYR1134
A	LYS988
A	THR1063
A	PRO1070
A	THR1072
A	ARG1161
B	HOH47
B	HOH148
B	HIS1110

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1183

Chain	Residue
A	HOH140
A	HOH141
A	HOH237
A	HIS1057
A	LYS1068
A	GLY1137
A	SER1138
A	ALA1139

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	HOH18
A	HOH127
A	THR1040
A	GLN1041
A	ARG1062
A	GLN1089
A	GLY1090

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	HOH90
A	GLY1120
A	ASP1121
B	ARG1161

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1184

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	CYS1097
B	CYS1099
B	CYS1145
B	HIS1149

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