3M58

SET7/9 Y245A in complex with TAF10-K189me1 peptide and AdoHcy

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005694	cellular_component	chromosome
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0140945	molecular_function	histone H3K4 monomethyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE SAH A 800

Chain	Residue
A	ALA226
A	GLU356
A	HOH423
A	HOH456
A	HOH458
A	HOH480
A	HOH569
A	HOH571
A	HOH585
A	HOH611
B	MLZ189
A	GLU228
A	GLY264
A	HIS293
A	LYS294
A	ASN296
A	HIS297
A	TYR335
A	TRP352

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 801

Chain	Residue
A	PRO350
A	GLU351
A	TRP352
A	HOH502
A	HOH673

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 802

Chain	Residue
A	TYR110
A	HIS283
A	VAL284
A	SER285
A	HOH460
B	LYS192

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	122
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12514135","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12540855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12514135","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12540855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Site: {"description":"Histone H3K4 binding","evidences":[{"source":"PubMed","id":"12540855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 350

Chain	Residue	Details
A	ALA245	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	HIS293	electrostatic stabiliser, hydrogen bond acceptor
A	HIS297	electrostatic stabiliser, hydrogen bond acceptor
A	TYR305	activator, electrostatic stabiliser, hydrogen bond acceptor
A	TYR335	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

---