3M3L

PEPA bound to the ligand binding domain of GluA2 (flop form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
G	0015276	molecular_function	ligand-gated monoatomic ion channel activity
G	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 400

Chain	Residue
A	TYR61
A	GLU193
A	HOH271
A	HOH272
A	HOH315
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143

---

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE P99 A 800

Chain	Residue
A	ILE92
A	LYS104
A	PRO105
A	PHE106
A	MET107
A	SER108
A	SER217
A	LYS218
A	GLY219
A	LEU239
A	ASN242
A	HOH376
A	HOH469
D	ILE92
D	LYS104
D	PRO105
D	PHE106
D	MET107
D	SER108
D	SER217
D	LYS218
D	GLY219
D	LEU239
D	ASN242
D	HOH583

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 262

Chain	Residue
A	GLU42
A	HIS46
A	HOH263
G	GLU166

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU D 400

Chain	Residue
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	LEU138
D	GLY141
D	SER142
D	THR143
D	GLU193
D	HOH267
D	HOH271
D	HOH348

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 1

Chain	Residue
A	HIS23
D	ASP65

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 2

Chain	Residue
D	GLU42
D	HIS46

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 262

Chain	Residue
D	HIS23
D	HOH742
D	HOH951
G	HIS23

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU G 400

Chain	Residue
G	TYR61
G	PRO89
G	LEU90
G	THR91
G	ARG96
G	GLY141
G	SER142
G	THR143
G	GLU193
G	TYR220
G	HOH272
G	HOH275
G	HOH294

---

site_id	AC9
Number of Residues	18
Details	BINDING SITE FOR RESIDUE P99 G 801

Chain	Residue
G	ILE92
G	PRO105
G	PRO105
G	PHE106
G	MET107
G	MET107
G	SER108
G	SER108
G	SER217
G	LYS218
G	LYS218
G	GLY219
G	GLY219
G	LEU239
G	ASN242
G	ASN242
G	HOH436
G	HOH446

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN G 3

Chain	Residue
G	GLN244
G	LEU246
A	GLU166
G	GLU42
G	LYS45
G	HIS46
G	LEU241

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
D	SER142
D	THR143
D	GLU193
G	PRO89
G	THR91
G	ARG96
G	SER142
G	THR143
G	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
D	PRO89
D	THR91
D	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
D	ARG64
D	ARG148
D	LYS240
G	ARG64
G	ARG148
G	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
D	ILE121
G	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
D	SER150
G	SER150

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
D	SER184
G	SER184

---