Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3M0W

Structure of S100A4 with PCP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001837	biological_process	epithelial to mesenchymal transition
A	0003723	molecular_function	RNA binding
A	0003779	molecular_function	actin binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0042056	molecular_function	chemoattractant activity
A	0042802	molecular_function	identical protein binding
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050786	molecular_function	RAGE receptor binding
A	0050918	biological_process	positive chemotaxis
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070062	cellular_component	extracellular exosome
B	0001837	biological_process	epithelial to mesenchymal transition
B	0003723	molecular_function	RNA binding
B	0003779	molecular_function	actin binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0042056	molecular_function	chemoattractant activity
B	0042802	molecular_function	identical protein binding
B	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
B	0046872	molecular_function	metal ion binding
B	0046914	molecular_function	transition metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050786	molecular_function	RAGE receptor binding
B	0050918	biological_process	positive chemotaxis
B	0062023	cellular_component	collagen-containing extracellular matrix
B	0070062	cellular_component	extracellular exosome
C	0001837	biological_process	epithelial to mesenchymal transition
C	0003723	molecular_function	RNA binding
C	0003779	molecular_function	actin binding
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0042056	molecular_function	chemoattractant activity
C	0042802	molecular_function	identical protein binding
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0046872	molecular_function	metal ion binding
C	0046914	molecular_function	transition metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050786	molecular_function	RAGE receptor binding
C	0050918	biological_process	positive chemotaxis
C	0062023	cellular_component	collagen-containing extracellular matrix
C	0070062	cellular_component	extracellular exosome
D	0001837	biological_process	epithelial to mesenchymal transition
D	0003723	molecular_function	RNA binding
D	0003779	molecular_function	actin binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0042056	molecular_function	chemoattractant activity
D	0042802	molecular_function	identical protein binding
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0046872	molecular_function	metal ion binding
D	0046914	molecular_function	transition metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0050786	molecular_function	RAGE receptor binding
D	0050918	biological_process	positive chemotaxis
D	0062023	cellular_component	collagen-containing extracellular matrix
D	0070062	cellular_component	extracellular exosome
E	0001837	biological_process	epithelial to mesenchymal transition
E	0003723	molecular_function	RNA binding
E	0003779	molecular_function	actin binding
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0042056	molecular_function	chemoattractant activity
E	0042802	molecular_function	identical protein binding
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0046872	molecular_function	metal ion binding
E	0046914	molecular_function	transition metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050786	molecular_function	RAGE receptor binding
E	0050918	biological_process	positive chemotaxis
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0070062	cellular_component	extracellular exosome
F	0001837	biological_process	epithelial to mesenchymal transition
F	0003723	molecular_function	RNA binding
F	0003779	molecular_function	actin binding
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0042056	molecular_function	chemoattractant activity
F	0042802	molecular_function	identical protein binding
F	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
F	0046872	molecular_function	metal ion binding
F	0046914	molecular_function	transition metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0050786	molecular_function	RAGE receptor binding
F	0050918	biological_process	positive chemotaxis
F	0062023	cellular_component	collagen-containing extracellular matrix
F	0070062	cellular_component	extracellular exosome
G	0001837	biological_process	epithelial to mesenchymal transition
G	0003723	molecular_function	RNA binding
G	0003779	molecular_function	actin binding
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0042056	molecular_function	chemoattractant activity
G	0042802	molecular_function	identical protein binding
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0046872	molecular_function	metal ion binding
G	0046914	molecular_function	transition metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0050786	molecular_function	RAGE receptor binding
G	0050918	biological_process	positive chemotaxis
G	0062023	cellular_component	collagen-containing extracellular matrix
G	0070062	cellular_component	extracellular exosome
H	0001837	biological_process	epithelial to mesenchymal transition
H	0003723	molecular_function	RNA binding
H	0003779	molecular_function	actin binding
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0042056	molecular_function	chemoattractant activity
H	0042802	molecular_function	identical protein binding
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0046872	molecular_function	metal ion binding
H	0046914	molecular_function	transition metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0050786	molecular_function	RAGE receptor binding
H	0050918	biological_process	positive chemotaxis
H	0062023	cellular_component	collagen-containing extracellular matrix
H	0070062	cellular_component	extracellular exosome
I	0001837	biological_process	epithelial to mesenchymal transition
I	0003723	molecular_function	RNA binding
I	0003779	molecular_function	actin binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0042056	molecular_function	chemoattractant activity
I	0042802	molecular_function	identical protein binding
I	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
I	0046872	molecular_function	metal ion binding
I	0046914	molecular_function	transition metal ion binding
I	0048306	molecular_function	calcium-dependent protein binding
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0050786	molecular_function	RAGE receptor binding
I	0050918	biological_process	positive chemotaxis
I	0062023	cellular_component	collagen-containing extracellular matrix
I	0070062	cellular_component	extracellular exosome
J	0001837	biological_process	epithelial to mesenchymal transition
J	0003723	molecular_function	RNA binding
J	0003779	molecular_function	actin binding
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0042056	molecular_function	chemoattractant activity
J	0042802	molecular_function	identical protein binding
J	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
J	0046872	molecular_function	metal ion binding
J	0046914	molecular_function	transition metal ion binding
J	0048306	molecular_function	calcium-dependent protein binding
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0050786	molecular_function	RAGE receptor binding
J	0050918	biological_process	positive chemotaxis
J	0062023	cellular_component	collagen-containing extracellular matrix
J	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE P77 A 203

Chain	Residue
A	ASP10
B	PHE89
I	GLU6
I	ASP10
J	CYS86

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 201

Chain	Residue
A	GLU33
A	SER20
A	GLU23
A	ASP25
A	LYS28

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 202

Chain	Residue
A	ASP63
A	ASN65
A	ASP67
A	GLU69
A	GLU74

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DIO A 102

Chain	Residue
A	MET85
C	PHE89

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P77 B 203

Chain	Residue
A	PHE89
B	ASP10
B	SER14
C	CYS86
C	PHE89
D	GLU6
D	P77203

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 201

Chain	Residue
B	SER20
B	GLU23
B	ASP25
B	LYS28
B	GLU33
B	HOH103

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 202

Chain	Residue
B	ASP63
B	ASN65
B	ASP67
B	GLU69
B	GLU74
B	HOH102

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P77 B 204

Chain	Residue
B	MET85
B	CYS86
B	GLU88
B	PHE93
I	P77203
J	PHE89
J	PHE93

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE P77 C 203

Chain	Residue
C	ASP10
C	SER14
D	PHE89
E	PHE45
E	CYS86
F	GLU6
F	ASP10
F	P77203

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 201

Chain	Residue
C	SER20
C	GLY21
C	LYS22
C	GLU23
C	ASP25
C	GLU33

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 202

Chain	Residue
C	ASP63
C	ASN65
C	ASP67
C	GLU69
C	GLU74

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P77 D 203

Chain	Residue
A	SER44
A	CYS86
B	GLU6
B	P77203
C	PHE89
D	ASP10
D	SER14

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 201

Chain	Residue
D	SER20
D	GLU23
D	ASP25
D	LYS28
D	GLU33

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 202

Chain	Residue
D	ASP63
D	ASN65
D	ASP67
D	GLU69
D	GLU74

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE P77 E 203

Chain	Residue
E	ASP10
E	SER14
F	PHE89
G	CYS86
H	GLU6
H	P77203

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 201

Chain	Residue
E	SER20
E	LYS28
E	LEU29
E	ASN30
E	GLU33

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 202

Chain	Residue
E	ASP63
E	SER64
E	ASN65
E	ASP67
E	GLU69

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE P77 F 203

Chain	Residue
D	CYS86
E	PHE89
F	ASP10
F	SER14
C	GLU6
C	ASP10
C	P77203
D	SER44

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 201

Chain	Residue
F	SER20
F	GLU23
F	ASP25
F	LYS28
F	GLU33

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 202

Chain	Residue
F	ASP63
F	ASN65
F	ASP67
F	GLU69
F	GLU74

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE P77 G 203

Chain	Residue
G	ASP10
H	PHE89
I	SER44
I	CYS86
J	GLU6
J	P77203

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 201

Chain	Residue
G	SER20
G	GLU23
G	ASP25
G	LYS28
G	GLU33

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 202

Chain	Residue
G	ASP63
G	ASN65
G	ASP67
G	GLU69
G	GLU74

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P77 H 203

Chain	Residue
E	ASP10
E	P77203
F	PHE45
F	CYS86
G	PHE89
H	ASP10
H	SER14

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 201

Chain	Residue
H	SER20
H	GLU23
H	ASP25
H	LYS28
H	GLU33
H	HOH102

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 202

Chain	Residue
H	ASP63
H	ASN65
H	ASP67
H	GLU69
H	GLU74

site_id	CC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE P77 I 203

Chain	Residue
A	GLU6
A	ASP10
B	SER44
B	CYS86
B	P77204
I	ASP10
I	SER14
J	PHE89

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P77 I 204

Chain	Residue
H	PHE89
H	PHE90
I	SER44
I	PHE45
I	GLY47
I	MET85
I	CYS86

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA I 201

Chain	Residue
I	SER20
I	GLU23
I	ASP25
I	LYS28
I	GLU33

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 202

Chain	Residue
I	ASP63
I	ASN65
I	ASP67
I	GLU69
I	GLU74
I	HOH102

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P77 J 203

Chain	Residue
G	GLU6
G	P77203
H	SER44
H	CYS86
H	PHE89
I	PHE89
J	ASP10

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA J 201

Chain	Residue
J	SER20
J	GLU23
J	ASP25
J	LYS28
J	GLU33
J	HOH103

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA J 202

Chain	Residue
J	ASP63
J	ASN65
J	ASP67
J	GLU69
J	GLU74
J	HOH102

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DIO J 1

Chain	Residue
B	PHE89
J	MET85
J	HOH105

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DSNRDNEVDfqEY

Chain	Residue	Details
A	ASP63-TYR75

site_id	PS00303
Number of Residues	22
Details	S100_CABP S-100/ICaBP type calcium binding protein signature. LMsnLDsnrDnevDFqEYcvFL

Chain	Residue	Details
A	LEU58-LEU79

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
F	LYS28
F	GLU33
G	LYS28
G	GLU33
H	LYS28
H	GLU33
I	LYS28
I	GLU33
J	LYS28
J	GLU33
A	LYS28
A	GLU33
B	LYS28
B	GLU33
C	LYS28
C	GLU33
D	LYS28
D	GLU33
E	LYS28
E	GLU33

site_id	SWS_FT_FI2
Number of Residues	50
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00448

Chain	Residue	Details
C	ASP63
C	ASN65
C	ASP67
C	GLU69
C	GLU74
D	ASP63
D	ASN65
D	ASP67
D	GLU69
D	GLU74
E	ASP63
E	ASN65
E	ASP67
E	GLU69
E	GLU74
F	ASP63
F	ASN65
F	ASP67
F	GLU69
F	GLU74
G	ASP63
G	ASN65
G	ASP67
G	GLU69
G	GLU74
H	ASP63
H	ASN65
H	ASP67
H	GLU69
H	GLU74
I	ASP63
I	ASN65
I	ASP67
I	GLU69
I	GLU74
J	ASP63
J	ASN65
J	ASP67
J	GLU69
J	GLU74
A	ASP63
A	ASN65
A	ASP67
A	GLU69
A	GLU74
B	ASP63
B	ASN65
B	ASP67
B	GLU69
B	GLU74

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: N-acetylalanine => ECO:0000250\|UniProtKB:P35466

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
G	ALA2
H	ALA2
I	ALA2
J	ALA2
F	ALA2

site_id	SWS_FT_FI4
Number of Residues	20
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS7
A	LYS35
B	LYS7
B	LYS35
C	LYS7
C	LYS35
D	LYS7
D	LYS35
E	LYS7
E	LYS35
F	LYS7
F	LYS35
G	LYS7
G	LYS35
H	LYS7
H	LYS35
I	LYS7
I	LYS35
J	LYS7
J	LYS35

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)