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3LW2

Mouse Plasminogen Activator Inhibitor-1 (PAI-1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001890biological_processplacenta development
A0002020molecular_functionprotease binding
A0004866molecular_functionendopeptidase inhibitor activity
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0008585biological_processfemale gonad development
A0009617biological_processresponse to bacterium
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010757biological_processnegative regulation of plasminogen activation
A0014912biological_processnegative regulation of smooth muscle cell migration
A0030194biological_processpositive regulation of blood coagulation
A0030195biological_processnegative regulation of blood coagulation
A0030336biological_processnegative regulation of cell migration
A0030414molecular_functionpeptidase inhibitor activity
A0031012cellular_componentextracellular matrix
A0032757biological_processpositive regulation of interleukin-8 production
A0032967biological_processpositive regulation of collagen biosynthetic process
A0033629biological_processnegative regulation of cell adhesion mediated by integrin
A0035491biological_processpositive regulation of leukotriene production involved in inflammatory response
A0042127biological_processregulation of cell population proliferation
A0042583cellular_componentchromaffin granule
A0045765biological_processregulation of angiogenesis
A0045766biological_processpositive regulation of angiogenesis
A0045861biological_processnegative regulation of proteolysis
A0048146biological_processpositive regulation of fibroblast proliferation
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0050729biological_processpositive regulation of inflammatory response
A0050820biological_processpositive regulation of coagulation
A0050829biological_processdefense response to Gram-negative bacterium
A0051549biological_processpositive regulation of keratinocyte migration
A0051918biological_processnegative regulation of fibrinolysis
A0061044biological_processnegative regulation of vascular wound healing
A0061045biological_processnegative regulation of wound healing
A0070062cellular_componentextracellular exosome
A0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
A0071222biological_processcellular response to lipopolysaccharide
A0071347biological_processcellular response to interleukin-1
A0071466biological_processcellular response to xenobiotic stimulus
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0090026biological_processpositive regulation of monocyte chemotaxis
A0090280biological_processpositive regulation of calcium ion import
A0090399biological_processreplicative senescence
A0097180cellular_componentserine protease inhibitor complex
A0097187biological_processdentinogenesis
A1901331biological_processpositive regulation of odontoblast differentiation
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1904090cellular_componentpeptidase inhibitor complex
A1905043biological_processpositive regulation of epithelium regeneration
A2000098biological_processnegative regulation of smooth muscle cell-matrix adhesion
A2000352biological_processnegative regulation of endothelial cell apoptotic process
A2001045biological_processnegative regulation of integrin-mediated signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. MVIDRSFLFvV
ChainResidueDetails
AMET352-VAL362

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSite: {"description":"Reactive bond"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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