3LVK

Crystal Structure of E.coli IscS-TusA complex (form 2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0008033	biological_process	tRNA processing
A	0016226	biological_process	iron-sulfur cluster assembly
A	0016740	molecular_function	transferase activity
A	0030170	molecular_function	pyridoxal phosphate binding
A	0031071	molecular_function	cysteine desulfurase activity
A	0044571	biological_process	[2Fe-2S] cluster assembly
A	0046872	molecular_function	metal ion binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	0002143	biological_process	tRNA wobble position uridine thiolation
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006400	biological_process	tRNA modification
B	0008033	biological_process	tRNA processing
B	0097163	molecular_function	sulfur carrier activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP A 764

Chain	Residue
A	GLY74
A	SER203
A	HIS205
A	LYS206
A	THR243
A	HOH441
A	ALA75
A	THR76
A	HIS104
A	MET151
A	ASN155
A	ASP180
A	THR182
A	GLN183

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Functional Information from PROSITE/UniProt

site_id	PS00595
Number of Residues	20
Details	AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. VDLMsfSGHKiygpk.GiGaL

Chain	Residue	Details
A	VAL197-LEU216

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site_id	PS01148
Number of Residues	25
Details	UPF0033 Uncharacterized protein family UPF0033 signature. LDalGlrCPePvMmvrktvrnmqpG

Chain	Residue	Details
B	LEU12-GLY36

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Cysteine persulfide intermediate => ECO:0000255|HAMAP-Rule:MF_00413

Chain	Residue	Details
B	CYS19

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000269|PubMed:20404999

Chain	Residue	Details
A	ALA75
A	GLN183
A	SER203
A	THR243

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00331

Chain	Residue	Details
A	ASN155

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: via persulfide group => ECO:0000255|HAMAP-Rule:MF_00331

Chain	Residue	Details
A	CYS328

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_00331, ECO:0000269|PubMed:20404999

Chain	Residue	Details
A	LYS206

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