3LUT

A Structural Model for the Full-length Shaker Potassium Channel Kv1.2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002244	biological_process	hematopoietic progenitor cell differentiation
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0014069	cellular_component	postsynaptic density
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0030424	cellular_component	axon
A	0034705	cellular_component	potassium channel complex
A	0043005	cellular_component	neuron projection
A	0043194	cellular_component	axon initial segment
A	0043679	cellular_component	axon terminus
A	0044224	cellular_component	juxtaparanode region of axon
A	0044325	molecular_function	transmembrane transporter binding
A	0044877	molecular_function	protein-containing complex binding
A	0045202	cellular_component	synapse
A	0045445	biological_process	myoblast differentiation
A	0050905	biological_process	neuromuscular process
A	0071805	biological_process	potassium ion transmembrane transport
A	0098839	cellular_component	postsynaptic density membrane
A	0098978	cellular_component	glutamatergic synapse
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
A	1990031	cellular_component	pinceau fiber
A	2000008	biological_process	regulation of protein localization to cell surface
B	0001508	biological_process	action potential
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0005251	molecular_function	delayed rectifier potassium channel activity
B	0005267	molecular_function	potassium channel activity
B	0005515	molecular_function	protein binding
B	0005768	cellular_component	endosome
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0014059	biological_process	regulation of dopamine secretion
B	0015271	molecular_function	outward rectifier potassium channel activity
B	0016020	cellular_component	membrane
B	0019228	biological_process	neuronal action potential
B	0019233	biological_process	sensory perception of pain
B	0019894	molecular_function	kinesin binding
B	0021554	biological_process	optic nerve development
B	0021633	biological_process	optic nerve structural organization
B	0021987	biological_process	cerebral cortex development
B	0022038	biological_process	corpus callosum development
B	0030027	cellular_component	lamellipodium
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0031258	cellular_component	lamellipodium membrane
B	0032809	cellular_component	neuronal cell body membrane
B	0033010	cellular_component	paranodal junction
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0034705	cellular_component	potassium channel complex
B	0042734	cellular_component	presynaptic membrane
B	0043005	cellular_component	neuron projection
B	0043194	cellular_component	axon initial segment
B	0043204	cellular_component	perikaryon
B	0043679	cellular_component	axon terminus
B	0044224	cellular_component	juxtaparanode region of axon
B	0044305	cellular_component	calyx of Held
B	0045188	biological_process	regulation of circadian sleep/wake cycle, non-REM sleep
B	0045202	cellular_component	synapse
B	0045211	cellular_component	postsynaptic membrane
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
B	0060078	biological_process	regulation of postsynaptic membrane potential
B	0071805	biological_process	potassium ion transmembrane transport
B	0097623	biological_process	potassium ion export across plasma membrane
B	0098978	cellular_component	glutamatergic synapse
B	0099505	biological_process	regulation of presynaptic membrane potential
B	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B	1905030	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAP A 368

Chain	Residue
A	GLY55
A	GLN214
A	TRP243
A	SER244
A	PRO245
A	LEU246
A	ALA247
A	CYS248
A	GLY249
A	SER252
A	LYS254
A	THR56
A	ARG264
A	LEU321
A	GLY323
A	SER325
A	GLN329
A	GLU332
A	ASN333
A	HOH395
A	HOH409
A	HOH410
A	TRP57
A	HOH419
A	HOH435
A	GLN63
A	ASP85
A	TYR90
A	ASN158
A	SER188
A	ARG189

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K B 500

Chain	Residue
B	THR374
B	THR374
B	THR374
B	THR374
B	K501
B	K501
B	K501
B	K501

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE K B 501

Chain	Residue
B	THR374
B	THR374
B	THR374
B	THR374
B	VAL375
B	VAL375
B	VAL375
B	VAL375
B	K500
B	K500
B	K500
B	K500
B	K502
B	K502
B	K502
B	K502

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE K B 502

Chain	Residue
B	VAL375
B	VAL375
B	VAL375
B	VAL375
B	GLY376
B	GLY376
B	GLY376
B	GLY376
B	K501
B	K501
B	K501
B	K501
B	K503
B	K503
B	K503
B	K503

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE K B 503

Chain	Residue
B	GLY376
B	GLY376
B	GLY376
B	GLY376
B	K502
B	K502
B	K502
B	K502

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"18672894","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21357749","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q13303","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	38
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12151401","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	24
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	32
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	11
Details	Intramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	7
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	13
Details	Region: {"description":"S4-S5 linker","evidences":[{"source":"PubMed","id":"16002579","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	5
Details	Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	1
Details	Site: {"description":"Important for normal, slow channel gating","evidences":[{"source":"PubMed","id":"17766348","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	Site: {"description":"Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin","evidences":[{"source":"PubMed","id":"25514171","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16770729","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---