3LTQ

Structure of Interleukin 1B solved by SAD using an inserted Lanthanide Binding Tag

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005615	cellular_component	extracellular space
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TB A 154

Chain	Residue
A	ASP53
A	ASN53
A	ASP53
A	TRP53
A	GLU53
A	GLU53

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 155

Chain	Residue
A	GLU113
A	HOH198
A	HOH287
A	TYR53
A	ILE53
A	GLY53

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 156

Chain	Residue
A	TRP120
A	HOH294

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site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SO4 A 157

Chain	Residue
A	ASP53
A	ASP53
A	ASP53
A	ASN53
A	ASN53
A	ASN53
A	HOH256
A	HOH256
A	HOH256
A	HOH304
A	HOH304
A	HOH304
A	HOH304
A	HOH304
A	HOH304
A	HOH312
A	HOH312
A	HOH312
A	HOH315
A	HOH315
A	HOH315

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DTNNDGWIEgdEL

Chain	Residue	Details
A	ASP53

---

site_id	PS00253
Number of Residues	21
Details	INTERLEUKIN_1 Interleukin-1 signature. FeSAqfPnwYISTsqaenmpV

Chain	Residue	Details
A	PHE112-VAL132

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	13
Details	Motif: {"description":"Involved in interaction with TMED10 C-terminus","evidences":[{"source":"PubMed","id":"32272059","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Involved in receptor binding"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Site: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"29030430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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