3LT5

X-ray Crystallographic structure of a Pseudomonas Aeruginosa Azoreductase in complex with balsalazide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003960	molecular_function	quinone reductase (NADPH) activity
A	0006979	biological_process	response to oxidative stress
A	0009055	molecular_function	electron transfer activity
A	0010181	molecular_function	FMN binding
A	0016491	molecular_function	oxidoreductase activity
A	0016652	molecular_function	oxidoreductase activity, acting on NAD(P)H as acceptor
A	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
B	0003960	molecular_function	quinone reductase (NADPH) activity
B	0006979	biological_process	response to oxidative stress
B	0009055	molecular_function	electron transfer activity
B	0010181	molecular_function	FMN binding
B	0016491	molecular_function	oxidoreductase activity
B	0016652	molecular_function	oxidoreductase activity, acting on NAD(P)H as acceptor
B	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE FMN B 213

Chain	Residue
A	PHE60
B	TYR98
B	ASN99
B	PHE100
B	SER145
B	ARG146
B	GLY147
B	GLY148
B	PHE151
B	GLU187
B	HOH222
A	BLQ215
B	HOH225
B	SER10
B	ARG12
B	SER16
B	GLN17
B	SER18
B	PRO96
B	MET97

---

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FMN A 213

Chain	Residue
A	SER10
A	ARG12
A	SER16
A	GLN17
A	SER18
A	PRO96
A	MET97
A	TYR98
A	ASN99
A	PHE100
A	SER145
A	ARG146
A	GLY147
A	GLY148
A	PHE151
A	GLU187
A	GLU188
A	BLQ216
A	HOH229
A	HOH272
B	PHE60

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 214

Chain	Residue
B	PRO47
B	PRO47
B	LEU48

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 215

Chain	Residue
A	LEU48
A	SER104
B	PRO47
B	LEU48
B	SER104
B	GLY105
B	HOH232
B	HOH253

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 214

Chain	Residue
A	LEU90
A	ARG139
A	ALA140
A	GLU178
A	THR180
A	ALA212

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BLQ A 215

Chain	Residue
A	PHE60
A	TYR131
A	PHE173
B	PHE151
B	ASN157
B	GLU188
B	FMN213

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE BLQ A 216

Chain	Residue
A	ASN99
A	PHE100
A	PHE151
A	ASN157
A	GLU188
A	FMN213
B	PHE60
B	TYR131
B	PHE173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01216","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17904577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20057057","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20417637","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22355582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3R6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N9Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20417637","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22355582","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3LT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3R6W","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20417637","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22355582","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24915188","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3R6W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N65","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N9Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20057057","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"20417637","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3KEG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LT5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Important in the architecture of the active site","evidences":[{"source":"PubMed","id":"20057057","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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