3LSL
Piracetam bound to the ligand binding domain of GluA2 (flop form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| G | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| G | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GLU A 400 |
| Chain | Residue |
| A | TYR61 |
| A | HOH287 |
| A | HOH289 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PZI A 800 |
| Chain | Residue |
| A | TYR35 |
| A | PHE106 |
| A | MET107 |
| A | ASN242 |
| A | LEU247 |
| A | ASP248 |
| A | LYS251 |
| A | HOH274 |
| A | PZI802 |
| D | SER217 |
| D | PZI801 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU D 399 |
| Chain | Residue |
| D | TYR61 |
| D | PRO89 |
| D | LEU90 |
| D | THR91 |
| D | ARG96 |
| D | LEU138 |
| D | GLY141 |
| D | SER142 |
| D | THR143 |
| D | GLU193 |
| D | TYR220 |
| D | HOH263 |
| D | HOH281 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PZI A 802 |
| Chain | Residue |
| A | ASP248 |
| A | ASN252 |
| A | PZI800 |
| D | ASP216 |
| D | SER217 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLU G 400 |
| Chain | Residue |
| G | TYR61 |
| G | PRO89 |
| G | LEU90 |
| G | THR91 |
| G | ARG96 |
| G | GLY141 |
| G | SER142 |
| G | THR143 |
| G | GLU193 |
| G | MET196 |
| G | HOH285 |
| G | HOH310 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PZI A 801 |
| Chain | Residue |
| A | ILE92 |
| A | PRO105 |
| A | MET107 |
| A | SER108 |
| A | SER217 |
| A | LYS218 |
| A | GLY219 |
| A | HOH263 |
| A | HOH442 |
| D | PRO105 |
| D | SER108 |
| D | ASN242 |
| D | PZI800 |
| D | PZI801 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PZI D 801 |
| Chain | Residue |
| A | PRO105 |
| A | SER108 |
| A | PZI800 |
| A | PZI801 |
| D | ILE92 |
| D | PRO105 |
| D | MET107 |
| D | SER108 |
| D | SER217 |
| D | LYS218 |
| D | GLY219 |
| D | HOH314 |
| D | HOH355 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PZI D 800 |
| Chain | Residue |
| A | SER217 |
| A | PZI801 |
| D | TYR35 |
| D | PHE106 |
| D | MET107 |
| D | ASN242 |
| D | LEU247 |
| D | ASP248 |
| D | LYS251 |
| D | HOH266 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PZI D 802 |
| Chain | Residue |
| A | ASP216 |
| A | SER217 |
| D | ASP248 |
| D | ASN252 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PZI G 800 |
| Chain | Residue |
| G | ASP248 |
| G | LYS251 |
| G | HOH497 |
| G | PZI801 |
| G | TYR35 |
| G | PHE106 |
| G | MET107 |
| G | SER217 |
| G | ASN242 |
| G | LEU247 |
| site_id | BC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PZI G 801 |
| Chain | Residue |
| G | ILE92 |
| G | PRO105 |
| G | PRO105 |
| G | MET107 |
| G | SER108 |
| G | SER108 |
| G | SER217 |
| G | LYS218 |
| G | GLY219 |
| G | ASN242 |
| G | HOH268 |
| G | HOH350 |
| G | HOH483 |
| G | PZI800 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PZI G 802 |
| Chain | Residue |
| G | ASN214 |
| G | ASP216 |
| G | SER217 |
| G | ASP248 |
| G | ASN252 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | HIS23 |
| A | HOH434 |
| G | HIS23 |
| G | GLU30 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 2 |
| Chain | Residue |
| A | GLU42 |
| A | LYS45 |
| A | HIS46 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN D 3 |
| Chain | Residue |
| A | ASP65 |
| A | ASP67 |
| D | HIS23 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN D 400 |
| Chain | Residue |
| D | GLU42 |
| D | HIS46 |
| G | GLU166 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN G 401 |
| Chain | Residue |
| D | GLU166 |
| G | GLU42 |
| G | HIS46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
