3LQJ

Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me3 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042800	molecular_function	histone methyltransferase activity (H3-K4 specific)
A	0071339	cellular_component	MLL1 complex
B	0042800	molecular_function	histone methyltransferase activity (H3-K4 specific)
B	0071339	cellular_component	MLL1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 3

Chain	Residue
A	CYS1569
A	CYS1572
A	HIS1596
A	CYS1599

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 4

Chain	Residue
A	CYS1588
A	CYS1591
A	CYS1621
A	CYS1624

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	CYS1572
B	HIS1596
B	CYS1599
B	CYS1569

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	CYS1588
B	CYS1591
B	CYS1621
B	CYS1624

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Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	56
Details	ZF_PHD_1 Zinc finger PHD-type signature. CplCdkcyddddyeskm................................MqCgk..Cdrw.VHskCenlsdemyeilsnlpesva..........................YtCvnC

Chain	Residue	Details
A	CYS1569-CYS1624

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635

Chain	Residue	Details
Q	ARG2
T	ARG2

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692

Chain	Residue	Details
Q	THR3
T	THR3

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
Q	M3L4
T	M3L4

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594

Chain	Residue	Details
Q	GLN5
T	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790

Chain	Residue	Details
Q	THR6
T	THR6

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433

Chain	Residue	Details
Q	ARG8
T	ARG8

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
Q	LYS9
T	LYS9

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