3LQI

Crystal structure of MLL1 PHD3-Bromo complexed with H3(1-9)K4me2 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042800	molecular_function	histone methyltransferase activity (H3-K4 specific)
A	0071339	cellular_component	MLL1 complex
B	0042800	molecular_function	histone methyltransferase activity (H3-K4 specific)
B	0071339	cellular_component	MLL1 complex
C	0042800	molecular_function	histone methyltransferase activity (H3-K4 specific)
C	0071339	cellular_component	MLL1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS1569
A	CYS1572
A	HIS1596
A	CYS1599

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2

Chain	Residue
A	CYS1588
A	CYS1591
A	CYS1621
A	CYS1624

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 3

Chain	Residue
B	CYS1572
B	HIS1596
B	CYS1599
B	CYS1569

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 4

Chain	Residue
B	CYS1588
B	CYS1591
B	CYS1621
B	CYS1624

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 5

Chain	Residue
C	CYS1569
C	CYS1572
C	HIS1596
C	CYS1599

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 6

Chain	Residue
C	CYS1588
C	CYS1591
C	CYS1621
C	CYS1624

---

Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	56
Details	ZF_PHD_1 Zinc finger PHD-type signature. CplCdkcyddddyeskm................................MqCgk..Cdrw.VHskCenlsdemyeilsnlpesva..........................YtCvnC

Chain	Residue	Details
A	CYS1569-CYS1624

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	183
Details	Zinc finger: {"description":"PHD-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	Region: {"description":"Interaction with histone H3K4me3","evidences":[{"source":"PubMed","id":"20677832","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"PubMed","id":"30867594","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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