3LQH

Crystal structure of MLL1 PHD3-Bromo in the free form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042800	molecular_function	histone methyltransferase activity (H3-K4 specific)
A	0071339	cellular_component	MLL1 complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	CYS1569
A	CYS1572
A	HIS1596
A	CYS1599

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1002

Chain	Residue
A	CYS1588
A	CYS1591
A	CYS1621
A	CYS1624

---

Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	56
Details	ZF_PHD_1 Zinc finger PHD-type signature. CplCdkcyddddyeskm................................MqCgk..Cdrw.VHskCenlsdemyeilsnlpesva..........................YtCvnC

Chain	Residue	Details
A	CYS1569-CYS1624

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	61
Details	Zinc finger: {"description":"PHD-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Region: {"description":"Interaction with histone H3K4me3","evidences":[{"source":"PubMed","id":"20677832","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---