3LQF
Crystal structure of the short-chain dehydrogenase Galactitol-Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD and erythritol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 255 |
| Chain | Residue |
| A | TRP254 |
| A | HOH317 |
| A | HOH336 |
| A | HOH344 |
| B | TRP254 |
| B | HOH301 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD A 257 |
| Chain | Residue |
| A | ILE23 |
| A | ASP42 |
| A | ARG43 |
| A | ALA65 |
| A | ASP66 |
| A | VAL67 |
| A | SER92 |
| A | LEU142 |
| A | GLY143 |
| A | SER144 |
| A | TYR159 |
| A | LYS163 |
| A | PRO189 |
| A | GLY190 |
| A | VAL192 |
| A | THR194 |
| A | GLU195 |
| A | MET196 |
| A | THR197 |
| A | MRY258 |
| A | HOH324 |
| A | HOH334 |
| A | HOH424 |
| A | HOH436 |
| A | GLY18 |
| A | SER21 |
| A | GLY22 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MRY A 258 |
| Chain | Residue |
| A | ALA96 |
| A | ASN151 |
| A | GLN154 |
| A | TYR191 |
| A | THR197 |
| A | MET200 |
| A | NAD257 |
| A | HOH436 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD B 257 |
| Chain | Residue |
| B | SER21 |
| B | GLY22 |
| B | ILE23 |
| B | ASP42 |
| B | ARG43 |
| B | GLU44 |
| B | ALA65 |
| B | ASP66 |
| B | VAL67 |
| B | SER92 |
| B | ALA93 |
| B | GLY94 |
| B | LEU142 |
| B | GLY143 |
| B | SER144 |
| B | TYR159 |
| B | LYS163 |
| B | GLY190 |
| B | VAL192 |
| B | THR194 |
| B | MET196 |
| B | THR197 |
| B | MRY258 |
| B | HOH319 |
| B | HOH371 |
| B | HOH399 |
| B | HOH419 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MRY B 258 |
| Chain | Residue |
| B | ALA96 |
| B | LEU98 |
| B | GLN154 |
| B | TYR159 |
| B | TYR191 |
| B | NAD257 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 255 |
| Chain | Residue |
| C | TRP254 |
| C | HOH339 |
| D | TRP254 |
| D | HOH307 |
| D | HOH327 |
| D | HOH339 |
| site_id | AC7 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAD C 257 |
| Chain | Residue |
| C | MET196 |
| C | THR197 |
| C | MRY258 |
| C | HOH360 |
| C | HOH369 |
| C | HOH415 |
| C | HOH416 |
| C | SER21 |
| C | GLY22 |
| C | ILE23 |
| C | ASP42 |
| C | ARG43 |
| C | ALA65 |
| C | ASP66 |
| C | VAL67 |
| C | SER92 |
| C | GLY94 |
| C | LEU142 |
| C | GLY143 |
| C | SER144 |
| C | TYR159 |
| C | LYS163 |
| C | PRO189 |
| C | GLY190 |
| C | VAL192 |
| C | THR194 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MRY C 258 |
| Chain | Residue |
| C | GLN154 |
| C | TYR159 |
| C | MET196 |
| C | THR197 |
| C | MET200 |
| C | NAD257 |
| C | HOH416 |
| site_id | AC9 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAD D 257 |
| Chain | Residue |
| D | SER21 |
| D | GLY22 |
| D | ILE23 |
| D | ASP42 |
| D | ARG43 |
| D | ALA65 |
| D | ASP66 |
| D | VAL67 |
| D | SER92 |
| D | ALA93 |
| D | GLY94 |
| D | LEU142 |
| D | GLY143 |
| D | SER144 |
| D | TYR159 |
| D | LYS163 |
| D | GLY190 |
| D | VAL192 |
| D | THR194 |
| D | MET196 |
| D | THR197 |
| D | MRY258 |
| D | HOH326 |
| D | HOH363 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MRY D 258 |
| Chain | Residue |
| D | GLN154 |
| D | NAD257 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:20410293 |
| Chain | Residue | Details |
| A | TYR159 | |
| B | TYR159 | |
| C | TYR159 | |
| D | TYR159 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20410293, ECO:0007744|PDB:2WDZ, ECO:0007744|PDB:2WSB, ECO:0007744|PDB:3LQF |
| Chain | Residue | Details |
| A | SER21 | |
| B | ASP66 | |
| B | TYR159 | |
| B | LYS163 | |
| B | VAL192 | |
| B | TRP254 | |
| C | SER21 | |
| C | ASP42 | |
| C | ASP66 | |
| C | TYR159 | |
| C | LYS163 | |
| A | ASP42 | |
| C | VAL192 | |
| C | TRP254 | |
| D | SER21 | |
| D | ASP42 | |
| D | ASP66 | |
| D | TYR159 | |
| D | LYS163 | |
| D | VAL192 | |
| D | TRP254 | |
| A | ASP66 | |
| A | TYR159 | |
| A | LYS163 | |
| A | VAL192 | |
| A | TRP254 | |
| B | SER21 | |
| B | ASP42 |
