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3LP2

HIV-1 reverse transcriptase with inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003964molecular_functionRNA-directed DNA polymerase activity
A0004523molecular_functionRNA-DNA hybrid ribonuclease activity
A0006278biological_processRNA-templated DNA biosynthetic process
B0003964molecular_functionRNA-directed DNA polymerase activity
B0006278biological_processRNA-templated DNA biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE LP9 A 601
ChainResidue
AVAL108
ATRP229
ALEU234
ATYR181
ATYR183
ATYR188
ALYS223
AGLU224
APRO226
APHE227
ALEU228

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MN A 602
ChainResidue
AASP443
AASP549
AARG557
AMN603

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MN A 603
ChainResidue
AASP443
AGLY444
AGLU478
AASP498
AMN602

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BASP110
BASP185
BASP186

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Essential for RT p66/p51 heterodimerization => ECO:0000250
ChainResidueDetails
BTRP401
BTRP414

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Cleavage; by viral protease; partial => ECO:0000250
ChainResidueDetails
BPHE440
AASP549

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Essential for RT p66/p51 heterodimerization => ECO:0000250
ChainResidueDetails
ATRP401
ATRP414

site_idSWS_FT_FI5
Number of Residues1
DetailsSITE: Cleavage; by viral protease; partial => ECO:0000250
ChainResidueDetails
APHE440

site_idSWS_FT_FI6
Number of Residues1
DetailsSITE: Cleavage; by viral protease => ECO:0000250
ChainResidueDetails
ALEU560

Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 175
ChainResidueDetails

226707

PDB entries from 2024-10-30

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