3LOU
Crystal structure of Formyltetrahydrofolate deformylase (YP_105254.1) from BURKHOLDERIA MALLEI ATCC 23344 at 1.90 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008864 | molecular_function | formyltetrahydrofolate deformylase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0008864 | molecular_function | formyltetrahydrofolate deformylase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0008864 | molecular_function | formyltetrahydrofolate deformylase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| C | 0016787 | molecular_function | hydrolase activity |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0008864 | molecular_function | formyltetrahydrofolate deformylase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| D | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 293 |
| Chain | Residue |
| A | ARG246 |
| A | HOH311 |
| A | HOH318 |
| B | ARG270 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 294 |
| Chain | Residue |
| A | HOH339 |
| A | HOH853 |
| A | HOH878 |
| A | HOH910 |
| A | ARG178 |
| A | HIS200 |
| A | TYR212 |
| A | LEU257 |
| A | ARG261 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 295 |
| Chain | Residue |
| A | ARG270 |
| A | EDO305 |
| A | HOH313 |
| A | HOH372 |
| A | HOH729 |
| B | ARG246 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 296 |
| Chain | Residue |
| A | SER102 |
| A | ASN130 |
| A | HIS131 |
| A | MSE180 |
| A | GLN181 |
| A | HOH351 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 297 |
| Chain | Residue |
| A | ARG94 |
| A | TRP115 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 298 |
| Chain | Residue |
| A | THR13 |
| A | LEU14 |
| A | SER15 |
| A | GLN85 |
| A | TRP86 |
| A | ALA87 |
| A | EDO299 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 299 |
| Chain | Residue |
| A | THR13 |
| A | ARG278 |
| A | VAL280 |
| A | EDO298 |
| A | HOH368 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 300 |
| Chain | Residue |
| A | GLU39 |
| A | ARG54 |
| A | VAL91 |
| A | GLU277 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 301 |
| Chain | Residue |
| A | MSE117 |
| A | LYS121 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 302 |
| Chain | Residue |
| A | ALA109 |
| A | LEU112 |
| A | PHE113 |
| A | LYS116 |
| A | HIS141 |
| C | PHE113 |
| C | LYS116 |
| C | EDO298 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 303 |
| Chain | Residue |
| A | ASP110 |
| A | PHE113 |
| A | ARG114 |
| A | HOH553 |
| C | ASP110 |
| C | PHE113 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 304 |
| Chain | Residue |
| A | ARG114 |
| A | GLU119 |
| A | ILE266 |
| A | ALA269 |
| A | HOH366 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 305 |
| Chain | Residue |
| A | VAL244 |
| A | GLU245 |
| A | ILE266 |
| A | ARG270 |
| A | SO4295 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 292 |
| Chain | Residue |
| B | ARG178 |
| B | HIS200 |
| B | TYR212 |
| B | LEU257 |
| B | ARG261 |
| B | HOH365 |
| B | HOH663 |
| B | HOH709 |
| B | HOH796 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 293 |
| Chain | Residue |
| B | SER102 |
| B | ASN130 |
| B | HIS131 |
| B | MSE180 |
| B | GLN181 |
| B | HOH368 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 294 |
| Chain | Residue |
| B | LYS210 |
| B | PRO211 |
| B | TYR212 |
| B | HIS213 |
| B | HOH663 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 295 |
| Chain | Residue |
| B | GLN140 |
| B | HIS141 |
| D | GLN140 |
| D | HIS141 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG B 296 |
| Chain | Residue |
| B | ARG32 |
| D | ARG32 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 297 |
| Chain | Residue |
| B | HOH583 |
| B | GLU39 |
| B | ARG54 |
| B | ILE276 |
| B | ARG278 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 298 |
| Chain | Residue |
| A | HIS249 |
| B | THR41 |
| B | PHE43 |
| B | PHE290 |
| B | HOH871 |
| B | HOH873 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 299 |
| Chain | Residue |
| B | SER250 |
| B | GLN255 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 300 |
| Chain | Residue |
| A | PRO132 |
| A | PHE145 |
| A | HOH422 |
| B | HIS147 |
| B | PRO149 |
| B | HOH537 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 301 |
| Chain | Residue |
| B | TRP115 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 292 |
| Chain | Residue |
| C | ARG178 |
| C | HIS200 |
| C | TYR212 |
| C | LEU257 |
| C | ARG261 |
| C | HOH333 |
| C | HOH360 |
| C | HOH912 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 293 |
| Chain | Residue |
| C | ARG270 |
| C | HOH377 |
| D | ARG246 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 294 |
| Chain | Residue |
| C | SER102 |
| C | LYS103 |
| C | ASN130 |
| C | HIS131 |
| C | MSE180 |
| C | GLN181 |
| C | HOH376 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG C 295 |
| Chain | Residue |
| C | GLU39 |
| C | ARG54 |
| C | VAL91 |
| C | ILE276 |
| C | GLU277 |
| C | HOH390 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 296 |
| Chain | Residue |
| C | THR13 |
| C | ARG278 |
| C | VAL280 |
| C | EDO300 |
| C | HOH870 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 297 |
| Chain | Residue |
| C | HIS89 |
| C | ALA93 |
| C | ARG94 |
| C | PRO95 |
| C | GLU172 |
| C | ARG278 |
| C | HOH388 |
| site_id | DC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO C 298 |
| Chain | Residue |
| A | PHE113 |
| A | LYS116 |
| A | EDO302 |
| C | ALA109 |
| C | PHE113 |
| C | LYS116 |
| C | HIS141 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 299 |
| Chain | Residue |
| A | ARG73 |
| C | ARG32 |
| C | HIS33 |
| C | GLU74 |
| site_id | DC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO C 300 |
| Chain | Residue |
| C | THR13 |
| C | LEU14 |
| C | SER15 |
| C | GLN85 |
| C | TRP86 |
| C | EDO296 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 292 |
| Chain | Residue |
| C | ARG246 |
| D | ARG270 |
| D | HOH348 |
| D | HOH818 |
| site_id | DC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 D 293 |
| Chain | Residue |
| D | ARG178 |
| D | HIS200 |
| D | TYR212 |
| D | LEU257 |
| D | ARG261 |
| D | HOH328 |
| D | HOH332 |
| D | HOH362 |
| D | HOH471 |
| D | HOH911 |
| site_id | DC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 294 |
| Chain | Residue |
| D | SER102 |
| D | ASN130 |
| D | HIS131 |
| D | MSE180 |
| D | GLN181 |
| D | HOH381 |
| site_id | DC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PEG D 295 |
| Chain | Residue |
| C | HIS249 |
| D | THR41 |
| D | VAL42 |
| D | PHE43 |
| D | PHE290 |
| D | GLN291 |
| D | HOH634 |
| D | HOH741 |
| D | HOH874 |
| site_id | EC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG D 296 |
| Chain | Residue |
| D | LYS210 |
| D | PRO211 |
| D | TYR212 |
| D | HIS213 |
| D | GLU254 |
| D | HOH471 |
| site_id | EC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO D 297 |
| Chain | Residue |
| D | ARG94 |
| D | TRP115 |
| site_id | EC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 298 |
| Chain | Residue |
| D | TYR179 |
| D | GLN181 |
| D | EDO300 |
| site_id | EC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO D 299 |
| Chain | Residue |
| D | ASN193 |
| D | PHE275 |
| D | VAL280 |
| D | HOH360 |
| site_id | EC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 300 |
| Chain | Residue |
| D | ASN197 |
| D | HIS228 |
| D | VAL230 |
| D | GLU236 |
| D | EDO298 |
| site_id | EC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 301 |
| Chain | Residue |
| D | GLU245 |
| D | ASP262 |
| D | ILE266 |
