Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016229 | molecular_function | steroid dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0047086 | molecular_function | ketosteroid monooxygenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 324 |
| Chain | Residue |
| A | ARG171 |
| A | ARG175 |
| A | HOH360 |
| A | HOH453 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 325 |
| Chain | Residue |
| A | HOH668 |
| A | HOH668 |
| A | GLY158 |
| A | MLY161 |
| A | MLY161 |
| A | HOH507 |
| A | HOH507 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 326 |
| Chain | Residue |
| A | MLY9 |
| A | MLY185 |
| A | HOH677 |
| site_id | AC4 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD A 327 |
| Chain | Residue |
| A | GLY22 |
| A | THR23 |
| A | TYR24 |
| A | ASP50 |
| A | TYR55 |
| A | LYS84 |
| A | HIS117 |
| A | SER166 |
| A | ASN167 |
| A | GLN190 |
| A | TYR216 |
| A | GLY217 |
| A | ALA218 |
| A | LEU219 |
| A | GLY220 |
| A | THR221 |
| A | GLN222 |
| A | TYR224 |
| A | LEU236 |
| A | ALA253 |
| A | ALA269 |
| A | GLN270 |
| A | GLU276 |
| A | GLU279 |
| A | ASN280 |
| A | MRD328 |
| A | HOH353 |
| A | HOH390 |
| A | HOH567 |
| A | HOH625 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MRD A 328 |
| Chain | Residue |
| A | TYR55 |
| A | HIS117 |
| A | TYR118 |
| A | TRP227 |
| A | PHE310 |
| A | NAD327 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LeeckdaglVKSIGVSNF |
| Chain | Residue | Details |
| A | LEU151-PHE168 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHVDTAyayqvEeeIG |
| Chain | Residue | Details |
| A | GLY45-GLY62 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR55 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|Ref.6 |
| Chain | Residue | Details |
| A | ASP50 | |
| A | TYR55 | |
| A | SER166 | |
| A | GLN190 | |
| A | TYR216 | |
| A | GLN270 | |
| A | GLY20 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS117 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Lowers pKa of active site Tyr => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS84 | |
