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3LK0

X-ray structure of bovine SC0067,Ca(2+)-S100B

Functional Information from GO Data
ChainGOidnamespacecontents
A0001726cellular_componentruffle
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005929cellular_componentcilium
A0006417biological_processregulation of translation
A0007155biological_processcell adhesion
A0007409biological_processaxonogenesis
A0007611biological_processlearning or memory
A0007613biological_processmemory
A0008270molecular_functionzinc ion binding
A0008284biological_processpositive regulation of cell population proliferation
A0015630cellular_componentmicrotubule cytoskeleton
A0016310biological_processphosphorylation
A0019210molecular_functionkinase inhibitor activity
A0036064cellular_componentciliary basal body
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043025cellular_componentneuronal cell body
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043231cellular_componentintracellular membrane-bounded organelle
A0044548molecular_functionS100 protein binding
A0045666biological_processpositive regulation of neuron differentiation
A0045917biological_processpositive regulation of complement activation
A0046872molecular_functionmetal ion binding
A0048143biological_processastrocyte activation
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050786molecular_functionRAGE receptor binding
A0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
A0097490biological_processsympathetic neuron projection extension
A1990138biological_processneuron projection extension
A1990845biological_processadaptive thermogenesis
B0001726cellular_componentruffle
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005929cellular_componentcilium
B0006417biological_processregulation of translation
B0007155biological_processcell adhesion
B0007409biological_processaxonogenesis
B0007611biological_processlearning or memory
B0007613biological_processmemory
B0008270molecular_functionzinc ion binding
B0008284biological_processpositive regulation of cell population proliferation
B0015630cellular_componentmicrotubule cytoskeleton
B0016310biological_processphosphorylation
B0019210molecular_functionkinase inhibitor activity
B0036064cellular_componentciliary basal body
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043025cellular_componentneuronal cell body
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043231cellular_componentintracellular membrane-bounded organelle
B0044548molecular_functionS100 protein binding
B0045666biological_processpositive regulation of neuron differentiation
B0045917biological_processpositive regulation of complement activation
B0046872molecular_functionmetal ion binding
B0048143biological_processastrocyte activation
B0048156molecular_functiontau protein binding
B0048168biological_processregulation of neuronal synaptic plasticity
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050786molecular_functionRAGE receptor binding
B0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
B0097490biological_processsympathetic neuron projection extension
B1990138biological_processneuron projection extension
B1990845biological_processadaptive thermogenesis
C0001726cellular_componentruffle
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005929cellular_componentcilium
C0006417biological_processregulation of translation
C0007155biological_processcell adhesion
C0007409biological_processaxonogenesis
C0007611biological_processlearning or memory
C0007613biological_processmemory
C0008270molecular_functionzinc ion binding
C0008284biological_processpositive regulation of cell population proliferation
C0015630cellular_componentmicrotubule cytoskeleton
C0016310biological_processphosphorylation
C0019210molecular_functionkinase inhibitor activity
C0036064cellular_componentciliary basal body
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043025cellular_componentneuronal cell body
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043231cellular_componentintracellular membrane-bounded organelle
C0044548molecular_functionS100 protein binding
C0045666biological_processpositive regulation of neuron differentiation
C0045917biological_processpositive regulation of complement activation
C0046872molecular_functionmetal ion binding
C0048143biological_processastrocyte activation
C0048156molecular_functiontau protein binding
C0048168biological_processregulation of neuronal synaptic plasticity
C0048306molecular_functioncalcium-dependent protein binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050786molecular_functionRAGE receptor binding
C0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
C0097490biological_processsympathetic neuron projection extension
C1990138biological_processneuron projection extension
C1990845biological_processadaptive thermogenesis
D0001726cellular_componentruffle
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005929cellular_componentcilium
D0006417biological_processregulation of translation
D0007155biological_processcell adhesion
D0007409biological_processaxonogenesis
D0007611biological_processlearning or memory
D0007613biological_processmemory
D0008270molecular_functionzinc ion binding
D0008284biological_processpositive regulation of cell population proliferation
D0015630cellular_componentmicrotubule cytoskeleton
D0016310biological_processphosphorylation
D0019210molecular_functionkinase inhibitor activity
D0036064cellular_componentciliary basal body
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043025cellular_componentneuronal cell body
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043231cellular_componentintracellular membrane-bounded organelle
D0044548molecular_functionS100 protein binding
D0045666biological_processpositive regulation of neuron differentiation
D0045917biological_processpositive regulation of complement activation
D0046872molecular_functionmetal ion binding
D0048143biological_processastrocyte activation
D0048156molecular_functiontau protein binding
D0048168biological_processregulation of neuronal synaptic plasticity
D0048306molecular_functioncalcium-dependent protein binding
D0048471cellular_componentperinuclear region of cytoplasm
D0050786molecular_functionRAGE receptor binding
D0071638biological_processnegative regulation of monocyte chemotactic protein-1 production
D0097490biological_processsympathetic neuron projection extension
D1990138biological_processneuron projection extension
D1990845biological_processadaptive thermogenesis
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 90
ChainResidue
AASP61
AASP63
AASP65
AGLU67
AGLU72
AHOH94

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 91
ChainResidue
ALYS26
AGLU31
ASER18
AGLU21
AASP23

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 90
ChainResidue
BASP61
BASP63
BASP65
BGLU67
BGLU72

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 91
ChainResidue
BSER18
BGLU21
BASP23
BLYS26
BGLU31
BHOH103

site_idAC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE Z80 B 92
ChainResidue
BHIS42
BPHE87

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 90
ChainResidue
CASP61
CASP63
CASP65
CGLU67
CGLU72
CHOH96

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 91
ChainResidue
CSER18
CGLU21
CASP23
CLYS26
CGLU31

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA D 90
ChainResidue
DSER18
DGLU21
DASP23
DLYS26
DGLU31

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 91
ChainResidue
DASP61
DASP63
DASP65
DGLU67
DGLU72
DHOH99

site_idBC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE Z80 D 92
ChainResidue
CHIS42
CPHE43
CCYS84
CPHE87
CPHE88
DHIS42
DPHE87

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DSDGDGECDfqEF
ChainResidueDetails
AASP61-PHE73

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. VMetLDsdgDgecDFqEFmaFV
ChainResidueDetails
AVAL56-VAL77

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P04271
ChainResidueDetails
AHIS15
BASP23
BHIS25
BHIS85
CHIS15
CSER18
CGLU21
CASP23
CHIS25
CHIS85
DHIS15
ASER18
DSER18
DGLU21
DASP23
DHIS25
DHIS85
AGLU21
AASP23
AHIS25
AHIS85
BHIS15
BSER18
BGLU21

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448
ChainResidueDetails
AASP61
BGLU72
CASP61
CASP63
CASP65
CGLU67
CGLU72
DASP61
DASP63
DASP65
DGLU67
AASP63
DGLU72
AASP65
AGLU67
AGLU72
BASP61
BASP63
BASP65
BGLU67

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylserine => ECO:0000269|PubMed:4026304
ChainResidueDetails
ASER1
BSER1
CSER1
DSER1

238268

PDB entries from 2025-07-02

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