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3LIK

Human MMP12 in complex with non-zinc chelating inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0031012cellular_componentextracellular matrix
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 264
ChainResidue
AHIS218
AHIS222
AHIS228
AHAE302

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 265
ChainResidue
AHIS168
AASP170
AHIS183
AHIS196

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 266
ChainResidue
AHOH24
AASP158
AGLY190
AGLY192
AASP194
AHOH17

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 267
ChainResidue
AHOH25
AHOH36
AASP124
AGLU199
AGLU201

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 268
ChainResidue
AASP175
AGLY176
AGLY178
AILE180
AASP198
AGLU201

site_idAC6
Number of Residues25
DetailsBINDING SITE FOR RESIDUE EEG A 301
ChainResidue
AHOH91
AHOH102
ATHR154
AGLY155
AMET156
AGLY178
AGLY179
AILE180
ALEU181
AALA182
AHIS218
AGLU219
APRO232
APRO232
ALYS233
AALA234
APHE237
APRO238
ATHR239
ATYR240
ALYS241
AHOH282
AHOH284
AHOH292
AHAE302

site_idAC7
Number of Residues10
DetailsBINDING SITE FOR RESIDUE HAE A 302
ChainResidue
AHOH1
AHOH82
AALA182
AHIS183
AHIS218
AGLU219
AHIS222
AHIS228
AZN264
AEEG301

site_idAC8
Number of Residues10
DetailsBINDING SITE FOR RESIDUE P6G A 303
ChainResidue
AHOH11
AHOH44
AHOH100
ASER150
ALYS151
AILE152
AASP171
AHIS172
AALA173
AHOH270

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE P6G A 304
ChainResidue
AHIS228
ASER229
ASER230

site_idBC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE P6G A 305
ChainResidue
AHOH83
AHOH87
APRO107
AVAL108
AASN126
AASP129
APRO187
ATHR205
AHOH325
AHOH329

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAVHEIGHSL
ChainResidueDetails
ATHR215-LEU224

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE:
ChainResidueDetails
AGLU219

site_idSWS_FT_FI2
Number of Residues19
DetailsBINDING:
ChainResidueDetails
AASP124
AGLY190
AGLY192
AASP194
AHIS196
AASP198
AGLU199
AGLU201
AHIS218
AHIS222
AHIS228
AASP158
AHIS168
AASP170
AASP175
AGLY176
AGLY178
AILE180
AHIS183

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PDB entries from 2024-11-13

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