Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE NAD A 332 |
Chain | Residue |
A | VAL27 |
A | GLU56 |
A | ASP57 |
A | LYS58 |
A | LEU59 |
A | LYS60 |
A | GLU62 |
A | SER80 |
A | GLY81 |
A | LYS83 |
A | ASP84 |
A | GLY28 |
A | TYR85 |
A | TYR85 |
A | THR97 |
A | ALA98 |
A | GLY99 |
A | ARG101 |
A | LEU137 |
A | HIS138 |
A | PRO139 |
A | GLU140 |
A | CYS29 |
A | SER163 |
A | HIS195 |
A | TYR246 |
A | ALA248 |
A | PYR333 |
A | ASP30 |
A | ASP30 |
A | ASP53 |
A | VAL54 |
A | MET55 |
A | MET55 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PYR A 333 |
Chain | Residue |
A | LEU167 |
A | ARG171 |
A | HIS195 |
A | NAD332 |
Functional Information from PROSITE/UniProt
site_id | PS00064 |
Number of Residues | 7 |
Details | L_LDH L-lactate dehydrogenase active site. IGQHGDS |
Chain | Residue | Details |
A | ILE192-SER198 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | GLY196 | |
Chain | Residue | Details |
A | ALA31 | |
A | GLN102 | |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | LEU110 | |
A | LEU141 | |
A | THR229 | |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: |
Chain | Residue | Details |
A | PHE172 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
A | HIS195 | |
A | ASP168 | |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1emd |
Chain | Residue | Details |
A | HIS195 | |
A | ARG171 | |
A | ASP168 | |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 584 |
Chain | Residue | Details |
A | LEU110 | electrostatic stabiliser |
A | SER169 | enhance reactivity |
A | PHE172 | electrostatic stabiliser |
A | GLY196 | proton acceptor, proton donor |