Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAD A 332 |
| Chain | Residue |
| A | VAL27 |
| A | GLU56 |
| A | ASP57 |
| A | LYS58 |
| A | LEU59 |
| A | LYS60 |
| A | GLU62 |
| A | SER80 |
| A | GLY81 |
| A | LYS83 |
| A | ASP84 |
| A | GLY28 |
| A | TYR85 |
| A | TYR85 |
| A | THR97 |
| A | ALA98 |
| A | GLY99 |
| A | ARG101 |
| A | LEU137 |
| A | HIS138 |
| A | PRO139 |
| A | GLU140 |
| A | CYS29 |
| A | SER163 |
| A | HIS195 |
| A | TYR246 |
| A | ALA248 |
| A | PYR333 |
| A | ASP30 |
| A | ASP30 |
| A | ASP53 |
| A | VAL54 |
| A | MET55 |
| A | MET55 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PYR A 333 |
| Chain | Residue |
| A | LEU167 |
| A | ARG171 |
| A | HIS195 |
| A | NAD332 |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. IGQHGDS |
| Chain | Residue | Details |
| A | ILE192-SER198 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"3430615","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | HIS195 | |
| A | ASP168 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | HIS195 | |
| A | ARG171 | |
| A | ASP168 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 584 |
| Chain | Residue | Details |
| A | VAL113 | electrostatic stabiliser |
| A | PHE172 | enhance reactivity |
| A | LEU175 | electrostatic stabiliser |
| A | VAL199 | proton acceptor, proton donor |
