3LD9

Crystal structure of thymidylate kinase from Ehrlichia chaffeensis at 2.15A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004798	molecular_function	thymidylate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006227	biological_process	dUDP biosynthetic process
A	0006233	biological_process	dTDP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0004798	molecular_function	thymidylate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006227	biological_process	dUDP biosynthetic process
B	0006233	biological_process	dTDP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0046940	biological_process	nucleoside monophosphate phosphorylation
C	0004798	molecular_function	thymidylate kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006227	biological_process	dUDP biosynthetic process
C	0006233	biological_process	dTDP biosynthetic process
C	0006235	biological_process	dTTP biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0016301	molecular_function	kinase activity
C	0046940	biological_process	nucleoside monophosphate phosphorylation
D	0004798	molecular_function	thymidylate kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006227	biological_process	dUDP biosynthetic process
D	0006233	biological_process	dTDP biosynthetic process
D	0006235	biological_process	dTTP biosynthetic process
D	0009165	biological_process	nucleotide biosynthetic process
D	0016301	molecular_function	kinase activity
D	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 300

Chain	Residue
A	ILE8
A	ASP9
A	GLY10
A	SER11
A	GLY12
A	LYS13
A	THR14
A	HOH256

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 300

Chain	Residue
B	ASP9
B	GLY10
B	SER11
B	GLY12
B	LYS13
B	THR14
B	HOH260
B	HOH275
B	ILE8

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 301

Chain	Residue
B	GLU38
B	ARG71
B	ARG93
B	PHE94
B	THR98
B	HOH204

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 300

Chain	Residue
C	ILE8
C	GLY10
C	SER11
C	GLY12
C	LYS13
C	THR14

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 300

Chain	Residue
D	ASP9
D	GLY10
D	SER11
D	GLY12
D	LYS13
D	THR14
D	HOH210
D	HOH237

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site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 301

Chain	Residue
D	GLU38
D	PHE67
D	ARG71
D	PHE94
D	THR98
D	HOH282

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Functional Information from PROSITE/UniProt

site_id	PS01331
Number of Residues	13
Details	THYMIDYLATE_KINASE Thymidylate kinase signature. ICDRFidSTiAYQ

Chain	Residue	Details
A	ILE90-GLN102

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00165

Chain	Residue	Details
A	GLY7
B	GLY7
C	GLY7
D	GLY7

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