Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3LBC

D-sialic acid aldolase complexed with L-arabinose

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0008747	molecular_function	N-acetylneuraminate lyase activity
A	0016829	molecular_function	lyase activity
A	0019262	biological_process	N-acetylneuraminate catabolic process
A	0042802	molecular_function	identical protein binding
A	0044010	biological_process	single-species biofilm formation
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0008747	molecular_function	N-acetylneuraminate lyase activity
B	0016829	molecular_function	lyase activity
B	0019262	biological_process	N-acetylneuraminate catabolic process
B	0042802	molecular_function	identical protein binding
B	0044010	biological_process	single-species biofilm formation
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0008747	molecular_function	N-acetylneuraminate lyase activity
C	0016829	molecular_function	lyase activity
C	0019262	biological_process	N-acetylneuraminate catabolic process
C	0042802	molecular_function	identical protein binding
C	0044010	biological_process	single-species biofilm formation
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0008747	molecular_function	N-acetylneuraminate lyase activity
D	0016829	molecular_function	lyase activity
D	0019262	biological_process	N-acetylneuraminate catabolic process
D	0042802	molecular_function	identical protein binding
D	0044010	biological_process	single-species biofilm formation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE LAI A 1550

Chain	Residue
A	GLY169
A	GLU192
A	HOH538
A	HOH551
A	HOH1515
A	SO41561
C	TYR172
C	HOH384

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1554

Chain	Residue
A	TYR43
A	GLY46
A	SER47
A	THR48
A	TYR137
A	LYS165
A	HOH327
A	ALA11

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 1561

Chain	Residue
A	PRO140
A	SER168
A	GLY169
A	TYR190
A	HOH662
A	HOH1086
A	HOH1285
A	HOH1489
A	HOH1515
A	LAI1550

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LAI B 1551

Chain	Residue
B	GLY169
B	GLU192
B	HOH472
B	HOH1517
B	SO41558
D	ASP170
D	TYR172

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 1556

Chain	Residue
B	ALA11
B	TYR43
B	GLY46
B	SER47
B	THR48
B	TYR137
B	LYS165
B	HOH1131

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 1558

Chain	Residue
B	PRO140
B	SER168
B	GLY169
B	TYR190
B	HOH729
B	HOH1026
B	HOH1485
B	LAI1551

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LAI C 1552

Chain	Residue
A	ASP170
A	TYR172
A	HOH426
C	GLY169
C	GLU192
C	HOH344
C	HOH669
C	HOH1506
C	SO41560

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 1557

Chain	Residue
C	ALA11
C	TYR43
C	GLY46
C	SER47
C	THR48
C	TYR137
C	LYS165
C	HOH1099
C	HOH1510

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 1560

Chain	Residue
C	SER168
C	GLY169
C	TYR190
C	HOH455
C	HOH991
C	HOH992
C	HOH1490
C	LAI1552

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LAI D 1553

Chain	Residue
D	GLY169
D	GLU192
D	HOH731
D	HOH1389
D	HOH1509
D	SO41559

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 D 1555

Chain	Residue
D	ALA11
D	TYR43
D	GLY46
D	SER47
D	THR48
D	TYR137
D	LYS165
D	HOH325
D	HOH1366

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 D 1559

Chain	Residue
D	SER168
D	GLY169
D	HOH466
D	HOH735
D	HOH1486
D	HOH1497
D	HOH1508
D	HOH1518
D	LAI1553

Functional Information from PROSITE/UniProt

site_id	PS00665
Number of Residues	18
Details	DHDPS_1 Dihydrodipicolinate synthase signature 1. GLYvgGSTGEAfvqslsE

Chain	Residue	Details
A	GLY41-GLU58

site_id	PS00666
Number of Residues	31
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YNIPalSgvkLtldqintlvtlpg.VgALKQT

Chain	Residue	Details
A	TYR137-THR167

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"24521460","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"source":"PubMed","id":"12711733","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19923724","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24521460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9047371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8081752","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9047371","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12711733","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1FDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HL2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24521460","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BWL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Site: {"description":"Required to correctly position the proton donor","evidences":[{"source":"PubMed","id":"24521460","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 553

Chain	Residue	Details
A	TYR137	proton acceptor, proton donor, proton relay
A	LYS165	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor

site_id	MCSA2
Number of Residues	2
Details	M-CSA 553

Chain	Residue	Details
B	TYR137	proton acceptor, proton donor, proton relay
B	LYS165	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor

site_id	MCSA3
Number of Residues	2
Details	M-CSA 553

Chain	Residue	Details
C	TYR137	proton acceptor, proton donor, proton relay
C	LYS165	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor

site_id	MCSA4
Number of Residues	2
Details	M-CSA 553

Chain	Residue	Details
D	TYR137	proton acceptor, proton donor, proton relay
D	LYS165	covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)