3LBC
D-sialic acid aldolase complexed with L-arabinose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044010 | biological_process | single-species biofilm formation |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044010 | biological_process | single-species biofilm formation |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0044010 | biological_process | single-species biofilm formation |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0044010 | biological_process | single-species biofilm formation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LAI A 1550 |
| Chain | Residue |
| A | GLY169 |
| A | GLU192 |
| A | HOH538 |
| A | HOH551 |
| A | HOH1515 |
| A | SO41561 |
| C | TYR172 |
| C | HOH384 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1554 |
| Chain | Residue |
| A | TYR43 |
| A | GLY46 |
| A | SER47 |
| A | THR48 |
| A | TYR137 |
| A | LYS165 |
| A | HOH327 |
| A | ALA11 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1561 |
| Chain | Residue |
| A | PRO140 |
| A | SER168 |
| A | GLY169 |
| A | TYR190 |
| A | HOH662 |
| A | HOH1086 |
| A | HOH1285 |
| A | HOH1489 |
| A | HOH1515 |
| A | LAI1550 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE LAI B 1551 |
| Chain | Residue |
| B | GLY169 |
| B | GLU192 |
| B | HOH472 |
| B | HOH1517 |
| B | SO41558 |
| D | ASP170 |
| D | TYR172 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1556 |
| Chain | Residue |
| B | ALA11 |
| B | TYR43 |
| B | GLY46 |
| B | SER47 |
| B | THR48 |
| B | TYR137 |
| B | LYS165 |
| B | HOH1131 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1558 |
| Chain | Residue |
| B | PRO140 |
| B | SER168 |
| B | GLY169 |
| B | TYR190 |
| B | HOH729 |
| B | HOH1026 |
| B | HOH1485 |
| B | LAI1551 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE LAI C 1552 |
| Chain | Residue |
| A | ASP170 |
| A | TYR172 |
| A | HOH426 |
| C | GLY169 |
| C | GLU192 |
| C | HOH344 |
| C | HOH669 |
| C | HOH1506 |
| C | SO41560 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1557 |
| Chain | Residue |
| C | ALA11 |
| C | TYR43 |
| C | GLY46 |
| C | SER47 |
| C | THR48 |
| C | TYR137 |
| C | LYS165 |
| C | HOH1099 |
| C | HOH1510 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1560 |
| Chain | Residue |
| C | SER168 |
| C | GLY169 |
| C | TYR190 |
| C | HOH455 |
| C | HOH991 |
| C | HOH992 |
| C | HOH1490 |
| C | LAI1552 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE LAI D 1553 |
| Chain | Residue |
| D | GLY169 |
| D | GLU192 |
| D | HOH731 |
| D | HOH1389 |
| D | HOH1509 |
| D | SO41559 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1555 |
| Chain | Residue |
| D | ALA11 |
| D | TYR43 |
| D | GLY46 |
| D | SER47 |
| D | THR48 |
| D | TYR137 |
| D | LYS165 |
| D | HOH325 |
| D | HOH1366 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1559 |
| Chain | Residue |
| D | SER168 |
| D | GLY169 |
| D | HOH466 |
| D | HOH735 |
| D | HOH1486 |
| D | HOH1497 |
| D | HOH1508 |
| D | HOH1518 |
| D | LAI1553 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:24521460 |
| Chain | Residue | Details |
| A | TYR137 | |
| B | TYR137 | |
| C | TYR137 | |
| D | TYR137 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Schiff-base intermediate with substrate => ECO:0000269|PubMed:12711733, ECO:0000269|PubMed:19923724, ECO:0000269|PubMed:24521460, ECO:0000269|PubMed:9047371, ECO:0000305|PubMed:8081752 |
| Chain | Residue | Details |
| A | LYS165 | |
| B | LYS165 | |
| C | LYS165 | |
| D | LYS165 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9047371, ECO:0000305|PubMed:12711733, ECO:0007744|PDB:1FDY, ECO:0007744|PDB:1FDZ, ECO:0007744|PDB:1HL2 |
| Chain | Residue | Details |
| A | SER47 | |
| A | THR48 | |
| B | SER47 | |
| B | THR48 | |
| C | SER47 | |
| C | THR48 | |
| D | SER47 | |
| D | THR48 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24521460, ECO:0007744|PDB:4BWL |
| Chain | Residue | Details |
| A | THR167 | |
| B | SER208 | |
| C | THR167 | |
| C | GLY189 | |
| C | ASP191 | |
| C | GLU192 | |
| C | SER208 | |
| D | THR167 | |
| D | GLY189 | |
| D | ASP191 | |
| D | GLU192 | |
| A | GLY189 | |
| D | SER208 | |
| A | ASP191 | |
| A | GLU192 | |
| A | SER208 | |
| B | THR167 | |
| B | GLY189 | |
| B | ASP191 | |
| B | GLU192 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | SITE: Required to correctly position the proton donor => ECO:0000305|PubMed:24521460 |
| Chain | Residue | Details |
| A | SER47 | |
| A | TYR110 | |
| B | SER47 | |
| B | TYR110 | |
| C | SER47 | |
| C | TYR110 | |
| D | SER47 | |
| D | TYR110 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 553 |
| Chain | Residue | Details |
| A | TYR137 | proton acceptor, proton donor, proton relay |
| A | LYS165 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 553 |
| Chain | Residue | Details |
| B | TYR137 | proton acceptor, proton donor, proton relay |
| B | LYS165 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor |
| site_id | MCSA3 |
| Number of Residues | 2 |
| Details | M-CSA 553 |
| Chain | Residue | Details |
| C | TYR137 | proton acceptor, proton donor, proton relay |
| C | LYS165 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor |
| site_id | MCSA4 |
| Number of Residues | 2 |
| Details | M-CSA 553 |
| Chain | Residue | Details |
| D | TYR137 | proton acceptor, proton donor, proton relay |
| D | LYS165 | covalently attached, electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor |
