Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3LAP

The Structure of the Intermediate Complex of the Arginine Repressor from Mycobacterium tuberculosis Bound to its DNA Operator and L-canavanine.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005667	cellular_component	transcription regulator complex
A	0005737	cellular_component	cytoplasm
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006525	biological_process	arginine metabolic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0008652	biological_process	amino acid biosynthetic process
A	0034618	molecular_function	arginine binding
A	0051259	biological_process	protein complex oligomerization
A	1900079	biological_process	regulation of arginine biosynthetic process
B	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005667	cellular_component	transcription regulator complex
B	0005737	cellular_component	cytoplasm
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006525	biological_process	arginine metabolic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0008652	biological_process	amino acid biosynthetic process
B	0034618	molecular_function	arginine binding
B	0051259	biological_process	protein complex oligomerization
B	1900079	biological_process	regulation of arginine biosynthetic process
C	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005667	cellular_component	transcription regulator complex
C	0005737	cellular_component	cytoplasm
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006525	biological_process	arginine metabolic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0008652	biological_process	amino acid biosynthetic process
C	0034618	molecular_function	arginine binding
C	0051259	biological_process	protein complex oligomerization
C	1900079	biological_process	regulation of arginine biosynthetic process
D	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005667	cellular_component	transcription regulator complex
D	0005737	cellular_component	cytoplasm
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006525	biological_process	arginine metabolic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0008652	biological_process	amino acid biosynthetic process
D	0034618	molecular_function	arginine binding
D	0051259	biological_process	protein complex oligomerization
D	1900079	biological_process	regulation of arginine biosynthetic process
E	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005667	cellular_component	transcription regulator complex
E	0005737	cellular_component	cytoplasm
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006525	biological_process	arginine metabolic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0008652	biological_process	amino acid biosynthetic process
E	0034618	molecular_function	arginine binding
E	0051259	biological_process	protein complex oligomerization
E	1900079	biological_process	regulation of arginine biosynthetic process
F	0000987	molecular_function	cis-regulatory region sequence-specific DNA binding
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005667	cellular_component	transcription regulator complex
F	0005737	cellular_component	cytoplasm
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006525	biological_process	arginine metabolic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0008652	biological_process	amino acid biosynthetic process
F	0034618	molecular_function	arginine binding
F	0051259	biological_process	protein complex oligomerization
F	1900079	biological_process	regulation of arginine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GGB A 200

Chain	Residue
A	HIS125
C	ASP146
C	ASP147
C	THR148
F	GLY122
F	ASP146
A	SER129
A	ASP132
A	THR142
A	ILE143
A	ALA144
A	HOH191
A	HOH619
C	GLY145

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 171

Chain	Residue
A	VAL90
A	GLY92
A	GLY93
A	THR94
A	HOH238
B	ASN17
B	ARG18
B	ALA19
B	SO4172

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 172

Chain	Residue
A	ASN17
A	ARG18
A	ALA19
A	HOH251
A	HOH377
B	VAL90
B	GLY92
B	GLY93
B	THR94

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GGB B 200

Chain	Residue
A	GLY145
A	ASP146
A	ASP147
A	THR148
B	HIS125
B	ALA128
B	SER129
B	ASP132
B	THR142
B	ALA144
B	HOH179
B	HOH196
E	ASP146

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 171

Chain	Residue
B	LYS67
B	ARG69
B	THR75
B	HOH191
B	HOH239
F	ALA65
F	LYS67

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 172

Chain	Residue
A	SER91
A	GLY92
A	SO4171
B	ALA16
B	ASN17
B	GLY20
B	HOH461

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GGB C 200

Chain	Residue
B	GLY145
B	ASP146
B	ASP147
B	THR148
C	HIS125
C	ALA128
C	SER129
C	ASP132
C	THR142
C	ILE143
C	ALA144
C	HOH178
C	HOH618
D	PRO121
D	GLY122
D	ASP146

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 171

Chain	Residue
C	ASN17
C	ARG18
C	ALA19
C	VAL90
C	GLY92
C	GLY93
C	THR94
C	SO4172
C	HOH650

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 C 172

Chain	Residue
C	ALA16
C	ASN17
C	ALA19
C	GLY20
C	SER91
C	SER91
C	GLY92
C	SO4171
C	HOH650

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GGB D 200

Chain	Residue
D	ILE143
D	ALA144
D	HOH182
D	HOH482
F	GLY145
F	ASP146
F	ASP147
F	THR148
C	PRO121
C	GLY122
C	ASP146
D	SER129
D	ASP132
D	THR142

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 171

Chain	Residue
A	GLN33
A	ARG35
D	ASP132
D	ALA135
F	ARG118

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 172

Chain	Residue
A	ARG35
A	GLY76
D	ALA135
D	LEU136
D	PRO137
D	HOH378

site_id	BC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GGB E 200

Chain	Residue
B	PRO121
B	GLY122
B	ASP146
D	GLY145
D	ASP146
D	ASP147
D	THR148
E	HIS125
E	ALA128
E	SER129
E	ASP132
E	THR142
E	ILE143
E	ALA144
E	HOH174
E	HOH211

site_id	BC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GGB F 200

Chain	Residue
A	PRO121
A	GLY122
A	ASP146
E	GLY145
E	ASP146
E	ASP147
E	THR148
F	HIS125
F	SER129
F	ASP132
F	THR142
F	ILE143
F	ALA144
F	HOH174
F	HOH178

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)