3L9W
KefC C-terminal domain in complex with KefF and GSH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003955 | molecular_function | NAD(P)H dehydrogenase (quinone) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0008753 | molecular_function | NADPH dehydrogenase (quinone) activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0010181 | molecular_function | FMN binding |
| A | 0015079 | molecular_function | potassium ion transmembrane transporter activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0050136 | molecular_function | NADH dehydrogenase (quinone) (non-electrogenic) activity |
| A | 0051453 | biological_process | regulation of intracellular pH |
| A | 0051454 | biological_process | intracellular pH elevation |
| A | 1901381 | biological_process | positive regulation of potassium ion transmembrane transport |
| A | 1903103 | cellular_component | potassium:proton antiporter complex |
| B | 0003955 | molecular_function | NAD(P)H dehydrogenase (quinone) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0008753 | molecular_function | NADPH dehydrogenase (quinone) activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0010181 | molecular_function | FMN binding |
| B | 0015079 | molecular_function | potassium ion transmembrane transporter activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0050136 | molecular_function | NADH dehydrogenase (quinone) (non-electrogenic) activity |
| B | 0051453 | biological_process | regulation of intracellular pH |
| B | 0051454 | biological_process | intracellular pH elevation |
| B | 1901381 | biological_process | positive regulation of potassium ion transmembrane transport |
| B | 1903103 | cellular_component | potassium:proton antiporter complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FMN A 2400 |
| Chain | Residue |
| A | HIS1008 |
| A | TYR1068 |
| A | THR1105 |
| A | THR1106 |
| A | GLY1107 |
| A | GLY1108 |
| A | THR1148 |
| A | PHE1149 |
| A | SER1014 |
| A | HIS1015 |
| A | ALA1016 |
| A | ASN1017 |
| A | PRO1064 |
| A | MET1065 |
| A | GLN1066 |
| A | TRP1067 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE AMP A 2401 |
| Chain | Residue |
| A | HOH59 |
| A | HOH275 |
| A | GLY408 |
| A | ARG409 |
| A | PHE410 |
| A | ASP429 |
| A | HIS430 |
| A | ASP431 |
| A | HIS434 |
| A | GLY448 |
| A | ASP449 |
| A | ALA450 |
| A | ASP472 |
| A | THR476 |
| A | ARG496 |
| B | HOH191 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 2402 |
| Chain | Residue |
| A | HOH85 |
| A | TYR1010 |
| A | PRO1011 |
| A | HIS1012 |
| B | HOH311 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 2402 |
| Chain | Residue |
| A | HOH50 |
| B | HOH277 |
| B | TYR1010 |
| B | PRO1011 |
| B | HIS1012 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE FMN B 2400 |
| Chain | Residue |
| B | HOH197 |
| B | HOH231 |
| B | HIS1008 |
| B | SER1014 |
| B | HIS1015 |
| B | ALA1016 |
| B | ASN1017 |
| B | PRO1064 |
| B | MET1065 |
| B | GLN1066 |
| B | TRP1067 |
| B | TYR1068 |
| B | THR1105 |
| B | THR1106 |
| B | GLY1107 |
| B | GLY1108 |
| B | HIS1112 |
| B | PHE1113 |
| B | THR1148 |
| B | PHE1149 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AMP B 2401 |
| Chain | Residue |
| B | HOH344 |
| B | PHE407 |
| B | GLY408 |
| B | ARG409 |
| B | PHE410 |
| B | ASP429 |
| B | ASP431 |
| B | HIS434 |
| B | ASP449 |
| B | ALA450 |
| B | ILE471 |
| B | ASP472 |
| B | THR476 |
| B | ARG496 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GSH B 1 |
| Chain | Residue |
| A | ARG409 |
| A | GLN412 |
| A | ARG416 |
| B | HOH137 |
| B | HOH191 |
| B | HOH218 |
| B | HOH219 |
| B | HOH261 |
| B | HOH318 |
| B | ARG498 |
| B | ASP499 |
| B | VAL500 |
| B | ARG516 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1177 |
| Chain | Residue |
| A | ARG416 |
| B | PHE547 |
| B | ASN551 |
| B | MET554 |
| B | TYR572 |
| B | LEU579 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19523906","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"in other chain"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01414","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19523906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21041667","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
