3L9I
Myosin VI nucleotide-free (mdinsert2) L310G mutant crystal structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003774 | molecular_function | cytoskeletal motor activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016459 | cellular_component | myosin complex |
| A | 0051015 | molecular_function | actin filament binding |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005813 | cellular_component | centrosome |
| C | 0005814 | cellular_component | centriole |
| C | 0005819 | cellular_component | spindle |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005938 | cellular_component | cell cortex |
| C | 0007099 | biological_process | centriole replication |
| C | 0007605 | biological_process | sensory perception of sound |
| C | 0007608 | biological_process | sensory perception of smell |
| C | 0016028 | cellular_component | rhabdomere |
| C | 0016056 | biological_process | rhodopsin mediated signaling pathway |
| C | 0016059 | biological_process | negative regulation of opsin-mediated signaling pathway |
| C | 0016060 | biological_process | metarhodopsin inactivation |
| C | 0016247 | molecular_function | channel regulator activity |
| C | 0030048 | biological_process | actin filament-based movement |
| C | 0030234 | molecular_function | enzyme regulator activity |
| C | 0030496 | cellular_component | midbody |
| C | 0031475 | cellular_component | myosin V complex |
| C | 0031476 | cellular_component | myosin VI complex |
| C | 0031477 | cellular_component | myosin VII complex |
| C | 0031489 | molecular_function | myosin V binding |
| C | 0032036 | molecular_function | myosin heavy chain binding |
| C | 0042052 | biological_process | rhabdomere development |
| C | 0046716 | biological_process | muscle cell cellular homeostasis |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048102 | biological_process | autophagic cell death |
| C | 0050911 | biological_process | detection of chemical stimulus involved in sensory perception of smell |
| C | 0051383 | biological_process | kinetochore organization |
| C | 0070855 | molecular_function | myosin VI head/neck binding |
| C | 0071361 | biological_process | cellular response to ethanol |
| C | 0072499 | biological_process | photoreceptor cell axon guidance |
| C | 0072686 | cellular_component | mitotic spindle |
| C | 0097431 | cellular_component | mitotic spindle pole |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TBU A 7134 |
| Chain | Residue |
| A | PHE206 |
| A | GLY207 |
| A | LEU229 |
| A | HOH825 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 1 |
| Chain | Residue |
| A | HOH948 |
| A | ASN477 |
| A | GLN481 |
| A | PHE582 |
| A | ARG667 |
| A | SER692 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 816 |
| Chain | Residue |
| A | LYS78 |
| A | VAL79 |
| A | SER82 |
| A | HOH1456 |
| A | HOH1548 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 817 |
| Chain | Residue |
| A | HIS213 |
| A | SER448 |
| A | SER449 |
| A | TYR450 |
| A | PHE451 |
| A | HOH884 |
| A | HOH1058 |
| A | HOH1132 |
| A | HOH1195 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 818 |
| Chain | Residue |
| A | ARG199 |
| A | TYR462 |
| A | PHE463 |
| A | GLU464 |
| A | HOH875 |
| A | HOH1102 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 819 |
| Chain | Residue |
| A | HIS11 |
| A | PRO12 |
| A | THR13 |
| A | HOH849 |
| A | HOH1289 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 820 |
| Chain | Residue |
| A | THR158 |
| A | LYS162 |
| A | VAL183 |
| A | LYS208 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 1148 |
| Chain | Residue |
| C | ASP20 |
| C | ASP22 |
| C | ASP24 |
| C | THR26 |
| C | GLU31 |
| C | HOH620 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 1149 |
| Chain | Residue |
| C | ASP56 |
| C | ASP58 |
| C | ASN60 |
| C | THR62 |
| C | GLU67 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 1151 |
| Chain | Residue |
| C | ASP129 |
| C | ASP131 |
| C | ASP133 |
| C | GLN135 |
| C | ASN137 |
| C | GLU140 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 1150 |
| Chain | Residue |
| C | ASP93 |
| C | ASP95 |
| C | ASN97 |
| C | PHE99 |
| C | GLU104 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL |
| Chain | Residue | Details |
| C | ASP20-LEU32 | |
| C | ASP56-PHE68 | |
| C | ASP93-LEU105 | |
| C | ASP129-PHE141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| C | ASP22 | |
| C | ASP24 | |
| C | THR26 | |
| C | GLU31 | |
| C | ASP20 | |
| C | ASP56 | |
| C | ASP58 | |
| C | ASN60 | |
| C | THR62 | |
| C | GLU67 | |
| C | ASP93 | |
| C | ASP95 | |
| C | ASN97 | |
| C | GLU104 | |
| C | ASP129 | |
| C | ASP131 | |
| C | ASP133 | |
| C | GLN135 | |
| C | GLU140 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Not N6-methylated |
| Chain | Residue | Details |
| C | LYS115 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250 |
| Chain | Residue | Details |
| C | ALA1 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000269|PubMed:17610210 |
| Chain | Residue | Details |
| C | LYS94 |
