3L95

Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0007219	biological_process	Notch signaling pathway
X	0007275	biological_process	multicellular organism development
X	0016020	cellular_component	membrane
X	0030154	biological_process	cell differentiation
Y	0007219	biological_process	Notch signaling pathway
Y	0007275	biological_process	multicellular organism development
Y	0016020	cellular_component	membrane
Y	0030154	biological_process	cell differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR194-HIS200
A	TYR192-HIS198

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VCSLqcNnHACGWDG

Chain	Residue	Details
X	VAL1463-GLY1477

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Repeat: {"description":"LNR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00525","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	41
Details	Repeat: {"description":"LNR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00525","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	78
Details	Repeat: {"description":"LNR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00525","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Cleavage; by ADAM17","evidences":[{"source":"UniProtKB","id":"Q01705","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"24226769","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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