3L95

Crystal structure of the human Notch1 Negative Regulatory Region (NRR) bound to the fab fragment of an antagonist antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0007219	biological_process	Notch signaling pathway
X	0007275	biological_process	multicellular organism development
X	0016020	cellular_component	membrane
X	0030154	biological_process	cell differentiation
Y	0007219	biological_process	Notch signaling pathway
Y	0007275	biological_process	multicellular organism development
Y	0016020	cellular_component	membrane
Y	0030154	biological_process	cell differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
B	TYR194-HIS200
A	TYR192-HIS198

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VCSLqcNnHACGWDG

Chain	Residue	Details
X	VAL1463-GLY1477

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
X	ASP1458
X	ASN1461
X	ASP1476
X	ASP1479
Y	ASP1458
Y	ASN1461
Y	ASP1476
Y	ASP1479

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by furin-like protease => ECO:0000250|UniProtKB:Q01705

Chain	Residue	Details
X	LEU1713
Y	LEU1713

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by ADAM17 => ECO:0000250|UniProtKB:Q01705

Chain	Residue	Details
X	GLY1711
Y	GLY1711

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
X	ASN1490
X	ASN1588
Y	ASN1490
Y	ASN1588

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:24226769

Chain	Residue	Details
X	THR1726
Y	THR1726

---