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3L5W

Crystal structure of the complex between IL-13 and C836 FAB

Functional Information from GO Data
ChainGOidnamespacecontents
I0001774biological_processmicroglial cell activation
I0002639biological_processpositive regulation of immunoglobulin production
I0005125molecular_functioncytokine activity
I0005126molecular_functioncytokine receptor binding
I0005144molecular_functioninterleukin-13 receptor binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0005737cellular_componentcytoplasm
I0006954biological_processinflammatory response
I0006955biological_processimmune response
I0007165biological_processsignal transduction
I0009612biological_processresponse to mechanical stimulus
I0009897cellular_componentexternal side of plasma membrane
I0010155biological_processregulation of proton transport
I0010628biological_processpositive regulation of gene expression
I0030890biological_processpositive regulation of B cell proliferation
I0032496biological_processresponse to lipopolysaccharide
I0032723biological_processpositive regulation of connective tissue growth factor production
I0032733biological_processpositive regulation of interleukin-10 production
I0035094biological_processresponse to nicotine
I0042116biological_processmacrophage activation
I0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
I0043032biological_processpositive regulation of macrophage activation
I0043270biological_processpositive regulation of monoatomic ion transport
I0043306biological_processpositive regulation of mast cell degranulation
I0045471biological_processresponse to ethanol
I0048661biological_processpositive regulation of smooth muscle cell proliferation
I0050714biological_processpositive regulation of protein secretion
I0050728biological_processnegative regulation of inflammatory response
I0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
I0071260biological_processcellular response to mechanical stimulus
I0071345biological_processcellular response to cytokine stimulus
I0071635biological_processnegative regulation of transforming growth factor beta production
I0120162biological_processpositive regulation of cold-induced thermogenesis
I1901247biological_processnegative regulation of lung ciliated cell differentiation
I1901251biological_processpositive regulation of lung goblet cell differentiation
I1903660biological_processnegative regulation of complement-dependent cytotoxicity
I2000231biological_processpositive regulation of pancreatic stellate cell proliferation
I2000352biological_processnegative regulation of endothelial cell apoptotic process
J0001774biological_processmicroglial cell activation
J0002639biological_processpositive regulation of immunoglobulin production
J0005125molecular_functioncytokine activity
J0005126molecular_functioncytokine receptor binding
J0005144molecular_functioninterleukin-13 receptor binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0005737cellular_componentcytoplasm
J0006954biological_processinflammatory response
J0006955biological_processimmune response
J0007165biological_processsignal transduction
J0009612biological_processresponse to mechanical stimulus
J0009897cellular_componentexternal side of plasma membrane
J0010155biological_processregulation of proton transport
J0010628biological_processpositive regulation of gene expression
J0030890biological_processpositive regulation of B cell proliferation
J0032496biological_processresponse to lipopolysaccharide
J0032723biological_processpositive regulation of connective tissue growth factor production
J0032733biological_processpositive regulation of interleukin-10 production
J0035094biological_processresponse to nicotine
J0042116biological_processmacrophage activation
J0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
J0043032biological_processpositive regulation of macrophage activation
J0043270biological_processpositive regulation of monoatomic ion transport
J0043306biological_processpositive regulation of mast cell degranulation
J0045471biological_processresponse to ethanol
J0048661biological_processpositive regulation of smooth muscle cell proliferation
J0050714biological_processpositive regulation of protein secretion
J0050728biological_processnegative regulation of inflammatory response
J0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
J0071260biological_processcellular response to mechanical stimulus
J0071345biological_processcellular response to cytokine stimulus
J0071635biological_processnegative regulation of transforming growth factor beta production
J0120162biological_processpositive regulation of cold-induced thermogenesis
J1901247biological_processnegative regulation of lung ciliated cell differentiation
J1901251biological_processpositive regulation of lung goblet cell differentiation
J1903660biological_processnegative regulation of complement-dependent cytotoxicity
J2000231biological_processpositive regulation of pancreatic stellate cell proliferation
J2000352biological_processnegative regulation of endothelial cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 1001
ChainResidue
AGLU38
AMET85
AGLY99
AGLY100
BGLN41
BLYS45
BGLY46
BLEU47

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
HTYR202-HIS208
LTYR192-HIS198

site_idPS00838
Number of Residues28
DetailsINTERLEUKIN_4_13 Interleukins -4 and -13 signature. LrELIeelvnITqnqkaplCngsmVwSI
ChainResidueDetails
ILEU10-ILE37

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
IASN19
IASN30
IASN38
IASN53
JASN19
JASN30
JASN38
JASN53

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PDB entries from 2024-07-24

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