3L2I
1.85 Angstrom Crystal Structure of the 3-Dehydroquinate Dehydratase (aroD) from Salmonella typhimurium LT2.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046279 | biological_process | 3,4-dihydroxybenzoate biosynthetic process |
| B | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046279 | biological_process | 3,4-dihydroxybenzoate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 253 |
| Chain | Residue |
| B | GLY12 |
| B | HOH315 |
| B | HOH321 |
| B | HOH324 |
| B | HOH354 |
Functional Information from PROSITE/UniProt
| site_id | PS01028 |
| Number of Residues | 31 |
| Details | DEHYDROQUINASE_I Dehydroquinase class I active site. DLELftgddevkatvgyahqhnvaVImSNHD |
| Chain | Residue | Details |
| A | ASP114-ASP144 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:21087925, ECO:0000269|PubMed:23341204, ECO:0000269|PubMed:24437575, ECO:0000269|Ref.4, ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | HIS143 | |
| B | HIS143 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Schiff-base intermediate with substrate => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:21087925, ECO:0000269|PubMed:23341204, ECO:0000269|Ref.4, ECO:0000269|Ref.7, ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | LYS170 | |
| B | LYS170 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:21087925, ECO:0000269|PubMed:24437575, ECO:0000269|Ref.4, ECO:0000269|Ref.7 |
| Chain | Residue | Details |
| A | SER21 | |
| B | SER21 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:21087925, ECO:0000269|PubMed:23341204, ECO:0000269|PubMed:24437575, ECO:0000269|Ref.4, ECO:0000269|Ref.7 |
| Chain | Residue | Details |
| A | GLU46 | |
| A | ARG213 | |
| A | GLN236 | |
| B | GLU46 | |
| B | ARG213 | |
| B | GLN236 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:21087925, ECO:0000269|PubMed:23341204, ECO:0000269|PubMed:24437575, ECO:0000269|Ref.4, ECO:0000269|Ref.7, ECO:0000269|Ref.8 |
| Chain | Residue | Details |
| A | ARG82 | |
| B | ARG82 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00214, ECO:0000269|PubMed:21087925, ECO:0000269|PubMed:24437575, ECO:0000269|Ref.4 |
| Chain | Residue | Details |
| A | SER232 | |
| B | SER232 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qfe |
| Chain | Residue | Details |
| A | LYS170 | |
| A | HIS143 | |
| A | GLU86 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qfe |
| Chain | Residue | Details |
| B | LYS170 | |
| B | HIS143 | |
| B | GLU86 |
