3KZW
Crystal structure of cytosol aminopeptidase from Staphylococcus aureus COL
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019538 | biological_process | protein metabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019538 | biological_process | protein metabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019538 | biological_process | protein metabolic process |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0019538 | biological_process | protein metabolic process |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070006 | molecular_function | metalloaminopeptidase activity |
| E | 0004177 | molecular_function | aminopeptidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006508 | biological_process | proteolysis |
| E | 0008233 | molecular_function | peptidase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0019538 | biological_process | protein metabolic process |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070006 | molecular_function | metalloaminopeptidase activity |
| F | 0004177 | molecular_function | aminopeptidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006508 | biological_process | proteolysis |
| F | 0008233 | molecular_function | peptidase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0019538 | biological_process | protein metabolic process |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070006 | molecular_function | metalloaminopeptidase activity |
| G | 0004177 | molecular_function | aminopeptidase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006508 | biological_process | proteolysis |
| G | 0008233 | molecular_function | peptidase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0019538 | biological_process | protein metabolic process |
| G | 0030145 | molecular_function | manganese ion binding |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0070006 | molecular_function | metalloaminopeptidase activity |
| H | 0004177 | molecular_function | aminopeptidase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006508 | biological_process | proteolysis |
| H | 0008233 | molecular_function | peptidase activity |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0019538 | biological_process | protein metabolic process |
| H | 0030145 | molecular_function | manganese ion binding |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0070006 | molecular_function | metalloaminopeptidase activity |
| I | 0004177 | molecular_function | aminopeptidase activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006508 | biological_process | proteolysis |
| I | 0008233 | molecular_function | peptidase activity |
| I | 0016787 | molecular_function | hydrolase activity |
| I | 0019538 | biological_process | protein metabolic process |
| I | 0030145 | molecular_function | manganese ion binding |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0070006 | molecular_function | metalloaminopeptidase activity |
| J | 0004177 | molecular_function | aminopeptidase activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006508 | biological_process | proteolysis |
| J | 0008233 | molecular_function | peptidase activity |
| J | 0016787 | molecular_function | hydrolase activity |
| J | 0019538 | biological_process | protein metabolic process |
| J | 0030145 | molecular_function | manganese ion binding |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0070006 | molecular_function | metalloaminopeptidase activity |
| K | 0004177 | molecular_function | aminopeptidase activity |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006508 | biological_process | proteolysis |
| K | 0008233 | molecular_function | peptidase activity |
| K | 0016787 | molecular_function | hydrolase activity |
| K | 0019538 | biological_process | protein metabolic process |
| K | 0030145 | molecular_function | manganese ion binding |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0070006 | molecular_function | metalloaminopeptidase activity |
| L | 0004177 | molecular_function | aminopeptidase activity |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006508 | biological_process | proteolysis |
| L | 0008233 | molecular_function | peptidase activity |
| L | 0016787 | molecular_function | hydrolase activity |
| L | 0019538 | biological_process | protein metabolic process |
| L | 0030145 | molecular_function | manganese ion binding |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 492 |
| Chain | Residue |
| A | HIS23 |
| A | LEU79 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 495 |
| Chain | Residue |
| A | ALA342 |
| A | GLY344 |
| A | ARG345 |
| A | LEU369 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 497 |
| Chain | Residue |
| A | GLY450 |
| A | HOH537 |
| A | HOH599 |
| A | SER387 |
| A | THR446 |
| A | SER449 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 498 |
| Chain | Residue |
| A | ASP379 |
| A | ALA460 |
| A | GLY461 |
| A | THR464 |
| A | HOH552 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 499 |
| Chain | Residue |
| A | ASN317 |
| A | GLU318 |
| B | ASN317 |
| B | GLU318 |
| C | ASN317 |
| C | GLU318 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 492 |
| Chain | Residue |
| B | LYS53 |
| B | VAL54 |
| B | HOH522 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 493 |
| Chain | Residue |
| B | HIS23 |
| B | LEU79 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 494 |
| Chain | Residue |
| B | THR328 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 496 |
| Chain | Residue |
| B | ALA342 |
| B | GLY344 |
| B | ARG345 |
| B | LEU369 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 498 |
| Chain | Residue |
| B | ASP379 |
| B | ALA460 |
| B | GLY461 |
| B | THR464 |
| B | HOH540 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 492 |
| Chain | Residue |
| C | LYS53 |
| C | VAL54 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 493 |
| Chain | Residue |
| C | HIS23 |
| C | LEU79 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL C 494 |
| Chain | Residue |
| C | THR328 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 496 |
| Chain | Residue |
| C | ALA342 |
| C | GLY344 |
| C | ARG345 |
| C | LEU369 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA C 498 |
| Chain | Residue |
| C | SER387 |
| C | THR446 |
| C | SER449 |
| C | GLY450 |
| C | HOH546 |
| C | HOH550 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 492 |
| Chain | Residue |
| D | LYS53 |
| D | VAL54 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 493 |
| Chain | Residue |
| D | HIS23 |
| D | LEU79 |
| site_id | BC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 494 |
| Chain | Residue |
| D | THR328 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 496 |
| Chain | Residue |
| D | ALA342 |
| D | GLY344 |
| D | ARG345 |
| D | LEU369 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 498 |
| Chain | Residue |
| D | SER387 |
| D | THR446 |
| D | SER449 |
| D | GLY450 |
| D | HOH572 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA D 499 |
| Chain | Residue |
| D | ASP379 |
| D | GLY461 |
| D | THR464 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 500 |
| Chain | Residue |
| D | ASN317 |
| D | GLU318 |
| D | HOH555 |
| E | ASN317 |
| E | GLU318 |
| F | ASN317 |
| F | GLU318 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL E 492 |
| Chain | Residue |
| E | LYS53 |
| E | VAL54 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL E 493 |
| Chain | Residue |
| E | PRO21 |
| E | HIS23 |
| E | GLN26 |
| E | LEU79 |
| site_id | CC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL E 494 |
| Chain | Residue |
| E | THR328 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL E 496 |
| Chain | Residue |
| E | ALA342 |
| E | GLY344 |
| E | ARG345 |
| E | LEU369 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA E 498 |
| Chain | Residue |
| E | SER387 |
| E | ASN388 |
| E | THR446 |
| E | SER449 |
| E | GLY450 |
| E | THR452 |
| E | HOH547 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA E 499 |
| Chain | Residue |
| E | ASP379 |
| E | GLY461 |
| E | THR464 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL F 492 |
| Chain | Residue |
| F | LEU79 |
| F | HIS23 |
| site_id | DC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL F 493 |
| Chain | Residue |
| F | THR328 |
| site_id | DC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL F 494 |
| Chain | Residue |
| F | HOH563 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL F 495 |
| Chain | Residue |
| F | ALA342 |
| F | GLY344 |
| F | ARG345 |
| F | LEU369 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA F 497 |
| Chain | Residue |
| F | ASP379 |
| F | GLY461 |
| F | THR464 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL G 492 |
| Chain | Residue |
| G | PRO21 |
| G | GLU22 |
| G | HIS23 |
| G | GLY77 |
| G | LEU79 |
| site_id | DC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL G 493 |
| Chain | Residue |
| G | THR328 |
| site_id | DC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL G 495 |
| Chain | Residue |
| G | ALA342 |
| G | GLY344 |
| G | ARG345 |
| G | LEU369 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA G 497 |
| Chain | Residue |
| G | SER387 |
| G | THR446 |
| G | SER449 |
| G | GLY450 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA G 498 |
| Chain | Residue |
| G | ASP379 |
| G | GLY461 |
| G | THR464 |
| site_id | EC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 G 499 |
| Chain | Residue |
| G | ASN317 |
| G | GLU318 |
| H | ASN317 |
| H | GLU318 |
| I | ASN317 |
| I | GLU318 |
| site_id | EC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL H 492 |
| Chain | Residue |
| H | LYS53 |
| H | VAL54 |
| site_id | EC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL H 493 |
| Chain | Residue |
| H | PRO21 |
| H | GLU22 |
| H | HIS23 |
| H | LEU79 |
| site_id | EC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL H 494 |
| Chain | Residue |
| H | THR328 |
| site_id | EC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL H 496 |
| Chain | Residue |
| H | ALA342 |
| H | GLY344 |
| H | ARG345 |
| H | LEU369 |
| site_id | EC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA H 498 |
| Chain | Residue |
| H | SER387 |
| H | THR446 |
| H | SER449 |
| H | GLY450 |
| H | HOH533 |
| site_id | EC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA H 499 |
| Chain | Residue |
| H | ASP379 |
| H | GLY461 |
| H | THR464 |
| site_id | FC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL I 492 |
| Chain | Residue |
| I | LYS53 |
| I | VAL54 |
| site_id | FC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL I 493 |
| Chain | Residue |
| I | HIS23 |
| I | GLN26 |
| I | LEU79 |
| site_id | FC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL I 494 |
| Chain | Residue |
| I | THR328 |
| site_id | FC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL I 496 |
| Chain | Residue |
| I | ALA342 |
| I | GLY344 |
| I | ARG345 |
| I | LEU369 |
| site_id | FC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA I 498 |
| Chain | Residue |
| I | SER387 |
| I | ASN388 |
| I | SER449 |
| I | GLY450 |
| I | THR452 |
| I | HOH570 |
| site_id | FC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL J 492 |
| Chain | Residue |
| J | LYS53 |
| J | VAL54 |
| site_id | FC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL J 493 |
| Chain | Residue |
| J | HIS23 |
| J | GLN26 |
| J | LEU79 |
| site_id | FC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL J 494 |
| Chain | Residue |
| J | THR328 |
| site_id | FC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL J 495 |
| Chain | Residue |
| J | ALA342 |
| J | GLY344 |
| J | ARG345 |
| J | LEU369 |
| site_id | GC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA J 497 |
| Chain | Residue |
| J | SER387 |
| J | THR446 |
| J | SER449 |
| J | GLY450 |
| J | THR452 |
| J | HOH533 |
| site_id | GC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 J 498 |
| Chain | Residue |
| J | ASN317 |
| J | GLU318 |
| K | ASN317 |
| K | GLU318 |
| L | ASN317 |
| L | GLU318 |
| site_id | GC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL K 492 |
| Chain | Residue |
| K | LYS53 |
| K | VAL54 |
| site_id | GC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL K 493 |
| Chain | Residue |
| K | GLU22 |
| K | HIS23 |
| K | GLY77 |
| K | LEU79 |
| site_id | GC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL K 494 |
| Chain | Residue |
| K | THR328 |
| site_id | GC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL K 495 |
| Chain | Residue |
| K | HOH595 |
| site_id | GC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL K 496 |
| Chain | Residue |
| K | ALA342 |
| K | GLY344 |
| K | ARG345 |
| K | LEU369 |
| site_id | GC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA K 498 |
| Chain | Residue |
| K | SER387 |
| K | ASN388 |
| K | SER449 |
| K | GLY450 |
| K | THR452 |
| K | HOH524 |
| site_id | GC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA K 499 |
| Chain | Residue |
| K | ASP379 |
| K | GLY461 |
| K | THR464 |
| K | HOH509 |
| site_id | HC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL L 492 |
| Chain | Residue |
| L | HIS23 |
| L | GLN26 |
| L | LEU79 |
| site_id | HC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL L 493 |
| Chain | Residue |
| L | THR328 |
| site_id | HC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL L 495 |
| Chain | Residue |
| L | ALA342 |
| L | GLY344 |
| L | ARG345 |
| L | LEU369 |
| site_id | HC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA L 497 |
| Chain | Residue |
| L | SER387 |
| L | ASN388 |
| L | THR446 |
| L | SER449 |
| L | GLY450 |
| L | THR452 |
| L | HOH511 |
| site_id | HC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA L 498 |
| Chain | Residue |
| L | ASP379 |
| L | ALA460 |
| L | GLY461 |
| L | THR464 |
| L | HOH525 |
Functional Information from PROSITE/UniProt
| site_id | PS00631 |
| Number of Residues | 8 |
| Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL |
| Chain | Residue | Details |
| A | ASN339-LEU346 |
