3KZM
Crystal structure of N-acetyl-L-ornithine transcarbamylase complexed with carbamyl phosphate
Replaces: 1ZQ2Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0019240 | biological_process | citrulline biosynthetic process |
| A | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| A | 0043857 | molecular_function | N-acetylornithine carbamoyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP A 346 |
| Chain | Residue |
| A | SER49 |
| A | LEU295 |
| A | ARG322 |
| A | HOH386 |
| A | MET50 |
| A | ARG51 |
| A | THR52 |
| A | TRP77 |
| A | ARG112 |
| A | HIS148 |
| A | GLN151 |
| A | CYS294 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 347 |
| Chain | Residue |
| A | SER13 |
| A | ARG14 |
| A | ALA15 |
| A | ARG198 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 350 |
| Chain | Residue |
| A | PHE61 |
| A | PHE61 |
| A | PHE61 |
| A | HIS66 |
| A | HIS66 |
| A | HIS66 |
| A | HOH342 |
| A | HOH342 |
| A | HOH342 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | BINDING: in other chain => ECO:0000269|PubMed:16741992, ECO:0000269|PubMed:17600144, ECO:0007744|PDB:3KZM, ECO:0007744|PDB:3KZO, ECO:0007744|PDB:3L02, ECO:0007744|PDB:3L04, ECO:0007744|PDB:3L05, ECO:0007744|PDB:3L06 |
| Chain | Residue | Details |
| A | SER49 | |
| A | ARG112 | |
| A | HIS148 | |
| A | CYS294 | |
| A | ARG322 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16741992, ECO:0000269|PubMed:17600144, ECO:0007744|PDB:3KZM, ECO:0007744|PDB:3KZO, ECO:0007744|PDB:3L02, ECO:0007744|PDB:3L04, ECO:0007744|PDB:3L05, ECO:0007744|PDB:3L06 |
| Chain | Residue | Details |
| A | TRP77 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16741992, ECO:0007744|PDB:3KZN |
| Chain | Residue | Details |
| A | GLU144 | |
| A | LYS252 | |
| A | LEU295 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine => ECO:0000269|PubMed:17600144 |
| Chain | Residue | Details |
| A | GLU92 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-carboxylysine => ECO:0000269|PubMed:20695527 |
| Chain | Residue | Details |
| A | KCX302 |
